Zobrazeno 1 - 10
of 305
pro vyhledávání: '"ERIK VAN DER GIESSEN"'
Publikováno v:
npj Computational Materials, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract The prediction of atomistic fracture mechanisms in body-centred cubic (bcc) iron is essential for understanding its semi-brittle nature. Existing atomistic simulations of the crack-tip under mode-I loading based on empirical interatomic pote
Externí odkaz:
https://doaj.org/article/8d2c6493225d4e8fa7e954ad13a4c057
Publikováno v:
eLife, Vol 12 (2024)
The disruption of nucleocytoplasmic transport (NCT) is an important mechanism in neurodegenerative diseases. In the case of C9orf72-ALS, trafficking of macromolecules through the nuclear pore complex (NPC) might get frustrated by the binding of C9orf
Externí odkaz:
https://doaj.org/article/fa2d8956aaca44549300cf73039c7270
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Nucleocytoplasmic transport (NCT) is affected in several neurodegenerative diseases including C9orf72-ALS. It has recently been found that arginine-containing dipeptide repeat proteins (R-DPRs), translated from C9orf72 repeat expansions, dir
Externí odkaz:
https://doaj.org/article/6421505f4c8746c7b97b82559d197650
Autor:
Alessio Fragasso, Hendrik W. de Vries, John Andersson, Eli O. van der Sluis, Erik van der Giessen, Andreas Dahlin, Patrick R. Onck, Cees Dekker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Intrinsically disordered FG-Nups line the Nuclear Pore Complex (NPC) lumen and form a selective barrier where transport of most proteins is inhibited, whereas specific transporter proteins are able to pass. Here, the authors reconstitute the selectiv
Externí odkaz:
https://doaj.org/article/4be48fd698744ead86133548fa049b92
Autor:
Irina L Rempel, Matthew M Crane, David J Thaller, Ankur Mishra, Daniel PM Jansen, Georges Janssens, Petra Popken, Arman Akşit, Matt Kaeberlein, Erik van der Giessen, Anton Steen, Patrick R Onck, C Patrick Lusk, Liesbeth M Veenhoff
Publikováno v:
eLife, Vol 8 (2019)
Nuclear transport is facilitated by the Nuclear Pore Complex (NPC) and is essential for life in eukaryotes. The NPC is a long-lived and exceptionally large structure. We asked whether NPC quality control is compromised in aging mitotic cells. Our ima
Externí odkaz:
https://doaj.org/article/e8d6ccf5e7ae4c7aa666b2f95e44167b
Autor:
Adithya N Ananth, Ankur Mishra, Steffen Frey, Arvind Dwarkasing, Roderick Versloot, Erik van der Giessen, Dirk Görlich, Patrick Onck, Cees Dekker
Publikováno v:
eLife, Vol 7 (2018)
Nuclear pore complexes (NPCs) lined with intrinsically disordered FG-domains act as selective gatekeepers for molecular transport between the nucleus and the cytoplasm in eukaryotic cells. The underlying physical mechanism of the intriguing selectivi
Externí odkaz:
https://doaj.org/article/c55ffbe4d9e44d70a597dfa2e4264ff7
The intrinsically disordered FG-Nups in the NPC central channel can undergo liquid-liquid phase sepration (LLPS) into liquid condensates that display NPC-like permeability barrier properties. Here we present LLPS characteristics of each of the disord
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::489af64d1f8e1dc5c7d9fabce43b51bd
https://doi.org/10.1101/2022.09.20.508740
https://doi.org/10.1101/2022.09.20.508740
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148876 (2016)
Molecular transport across the nuclear envelope in eukaryotic cells is solely controlled by the nuclear pore complex (NPC). The NPC provides two types of nucleocytoplasmic transport: passive diffusion of small molecules and active chaperon-mediated t
Externí odkaz:
https://doaj.org/article/076e0ceb1be64cfe8d045e5bbabed157
Publikováno v:
Biophys J
Biophysical Journal, 119(4), 843-851. CELL PRESS
Biophysical Journal, 119(4), 843-851. CELL PRESS
The expansion mutation in the C9orf72 gene is the most common known genetic cause for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This mutation can produce five dipeptide repeat proteins (DPRs), of which three are known to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9f0a66064a82b8971c2480f2346f6a3
https://doi.org/10.1016/j.bpj.2020.07.005
https://doi.org/10.1016/j.bpj.2020.07.005
Autor:
Erik van der Giessen, Alan Needleman
Publikováno v:
Encyclopedia of Materials: Metals and Alloys, 4, 541-551
Plastic deformation of crystalline metals mainly takes place by the nucleation and motion of dislocations, line defects in the atomic lattice. At a length scales of micrometers, dislocations can conveniently be idealized as discrete line defects in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0ecb12e91c72c44e24073b7b743ad7
https://doi.org/10.1016/b978-0-12-819726-4.00043-0
https://doi.org/10.1016/b978-0-12-819726-4.00043-0