Zobrazeno 1 - 10
of 446
pro vyhledávání: '"ERIK A. RICHTER"'
Autor:
Jaroslawna Meister, Derek B. J. Bone, Jonas R. Knudsen, Luiz F. Barella, Thomas J. Velenosi, Dmitry Akhmedov, Regina J. Lee, Amanda H. Cohen, Oksana Gavrilova, Yinghong Cui, Gerard Karsenty, Min Chen, Lee S. Weinstein, Maximilian Kleinert, Rebecca Berdeaux, Thomas E. Jensen, Erik A. Richter, Jürgen Wess
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
In this study, the authors demonstrated that agents targeting skeletal muscle metabolism by modulating β2-adrenergic receptor-dependent signaling may prove beneficial as novel antidiabetic drugs.
Externí odkaz:
https://doaj.org/article/59a46724f573486ab78cf2fe37925d04
Autor:
Anders B. Klein, Trine S. Nicolaisen, Niels Ørtenblad, Kasper D. Gejl, Rasmus Jensen, Andreas M. Fritzen, Emil L. Larsen, Kristian Karstoft, Henrik E. Poulsen, Thomas Morville, Ronni E. Sahl, Jørn W. Helge, Jens Lund, Sarah Falk, Mark Lyngbæk, Helga Ellingsgaard, Bente K. Pedersen, Wei Lu, Brian Finan, Sebastian B. Jørgensen, Randy J. Seeley, Maximilian Kleinert, Bente Kiens, Erik A. Richter, Christoffer Clemmensen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
The physiological role of GDF15 remains poorly defined. Here, the authors show that circulating GDF15 increases in response to prolonged exercise, but that this exercise-induced GDF15, unlike pharmacological GDF15, does not affect post-exercise food
Externí odkaz:
https://doaj.org/article/8f1d9eea4091471ca84ea46086fb7636
Autor:
Steffen H. Raun, Carlos Henriquez-Olguín, Iuliia Karavaeva, Mona Ali, Lisbeth L. V. Møller, Witold Kot, Josué L. Castro-Mejía, Dennis Sandris Nielsen, Zachary Gerhart-Hines, Erik A. Richter, Lykke Sylow
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Exercise has been shown to be an effective approach to ameliorate metabolic disease in mice housed at ambient temperatures, a condition of mild cold stress to mice. Here the authors show that molecular and metabolic adaptations to exercise are blunte
Externí odkaz:
https://doaj.org/article/35e98f4102a140c2b0947589200d505a
Autor:
Anne-Marie Lundsgaard, Andreas M. Fritzen, Trine S. Nicolaisen, Christian S. Carl, Kim A. Sjøberg, Steffen H. Raun, Anders B. Klein, Eva Sanchez-Quant, Jakob Langer, Cathrine Ørskov, Christoffer Clemmensen, Matthias H. Tschöp, Erik A. Richter, Bente Kiens, Maximilian Kleinert
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 1, Pp 10-19 (2020)
Excessive circulating FAs have been proposed to promote insulin resistance (IR) of glucose metabolism by increasing the oxidation of FAs over glucose. Therefore, inhibition of FA oxidation (FAOX) has been suggested to ameliorate IR. However, prolonge
Externí odkaz:
https://doaj.org/article/d93f2afb21af4c3f990999f0bf005ed4
Autor:
Carlos Henríquez-Olguin, Jonas R. Knudsen, Steffen H. Raun, Zhencheng Li, Emilie Dalbram, Jonas T. Treebak, Lykke Sylow, Rikard Holmdahl, Erik A. Richter, Enrique Jaimovich, Thomas E. Jensen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Reactive oxygen species (ROS) stimulate GLUT4-mediated glucose transport following contraction of isolated muscle, but it is not clear if this occurs in vivo. Here, the authors show in human volunteers that exercise induces ROS increase in muscle and
Externí odkaz:
https://doaj.org/article/a635b493f521447c82852adb296d2252
Autor:
Janne R. Hingst, Lea Bruhn, Mads B. Hansen, Marie F. Rosschou, Jesper B. Birk, Joachim Fentz, Marc Foretz, Benoit Viollet, Kei Sakamoto, Nils J. Færgeman, Jesper F. Havelund, Benjamin L. Parker, David E. James, Bente Kiens, Erik A. Richter, Jørgen Jensen, Jørgen F.P. Wojtaszewski
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 24-34 (2018)
Objective: A single bout of exercise followed by intake of carbohydrates leads to glycogen supercompensation in prior exercised muscle. Our objective was to illuminate molecular mechanisms underlying this phenomenon in skeletal muscle of man. Methods
Externí odkaz:
https://doaj.org/article/a0f13e6c4f264a02a10483039f72c400
Autor:
Jonas R. Knudsen, Dorte E. Steenberg, Janne R. Hingst, Lorna R. Hodgson, Carlos Henriquez-Olguin, Zhencheng Li, Bente Kiens, Erik A. Richter, Jørgen F.P. Wojtaszewski, Paul Verkade, Thomas E. Jensen
Publikováno v:
Molecular Metabolism, Vol 39, Iss , Pp - (2020)
Objective: Exercise is a cornerstone in the management of skeletal muscle insulin-resistance. A well-established benefit of a single bout of exercise is increased insulin sensitivity for hours post-exercise in the previously exercised musculature. Al
Externí odkaz:
https://doaj.org/article/6f85458e27874852be1ceb0f9f6bc40a
Autor:
Lisbeth L. V. Møller, Ida L. Nielsen, Jonas R. Knudsen, Nicoline R. Andersen, Thomas E. Jensen, Lykke Sylow, Erik A. Richter
Publikováno v:
Physiological Reports, Vol 8, Iss 12, Pp n/a-n/a (2020)
Abstract Aim Muscle contraction stimulates skeletal muscle glucose transport. Since it occurs independently of insulin, it is an important alternative pathway to increase glucose transport in insulin‐resistant states, but the intracellular signalin
Externí odkaz:
https://doaj.org/article/696e4e5987b24d4a81beb27350263efa
Autor:
Jonas M. Kristensen, Christian Lillelund, Rasmus Kjøbsted, Jesper B. Birk, Nicoline R. Andersen, Lars Nybo, Karin Mellberg, Anudharan Balendran, Erik A. Richter, Jørgen F. P. Wojtaszewski
Publikováno v:
Physiological Reports, Vol 7, Iss 23, Pp n/a-n/a (2019)
Abstract 5´AMP–activated protein kinase (AMPK) is a mediator of a healthy metabolic phenotype in skeletal muscle. Metformin may exacerbate the energy disturbances observed during exercise leading to enhanced AMPK activation, and these disturbances
Externí odkaz:
https://doaj.org/article/be2109d25b604c91b5ee695c4d03de8e
Autor:
Maximilian Kleinert, Benjamin L. Parker, Thomas E. Jensen, Steffen H. Raun, Phung Pham, Xiuqing Han, David E. James, Erik A. Richter, Lykke Sylow
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Regular exercise elicits advantageous metabolic adaptations in skeletal muscle, such as improved insulin sensitivity. However, the underpinning molecular mechanisms and the effect of diet on muscle exercise training benefits are unclear. We
Externí odkaz:
https://doaj.org/article/eda40db4d0774fd8ac07f18e01d47f8d