Zobrazeno 1 - 10
of 196
pro vyhledávání: '"ERCC5"'
Autor:
T. M. Zavarykina, P. K. Lomskova, M. A. Kapralova, O. O. Gordeeva, I. P. Ganshina, D. S. Khodyrev, S. V. Khokhlova, I. V. Kolyadina
Publikováno v:
Опухоли женской репродуктивной системы, Vol 18, Iss 4, Pp 69-80 (2023)
Background. Breast cancer is the most common cancer among women. Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, in which there are no special targets for therapy. Therefore chemotherapy is still leading treatmen
Externí odkaz:
https://doaj.org/article/5ed10ee33c6541e192682c3fd761a34a
Publikováno v:
FEBS Open Bio, Vol 12, Iss 10, Pp 1814-1827 (2022)
The mortality rate of patients with coronary artery disease (CAD) increases year by year, and the age of onset is decreasing, primarily because of the lack of an efficient and convenient diagnostic method for CAD. In the present study, we aimed to de
Externí odkaz:
https://doaj.org/article/89687be02426480d874aebeac3b38cd9
Autor:
Ting Zou, Jun-Yan Liu, Qun Qin, Jie Guo, Wen-Zhi Zhou, Xiang-Ping Li, Hong-Hao Zhou, Juan Chen, Zhao-Qian Liu
Publikováno v:
Biomedicines, Vol 11, Iss 12, p 3133 (2023)
Background: Lung cancer is still the most lethal malignancy in the world, according to the report of Cancer Statistics in 2021. Platinum-based chemotherapy combined with immunotherapy is the first-line treatment in lung cancer patients. However, the
Externí odkaz:
https://doaj.org/article/630db547cdcb4b88868f70de777885e6
Publikováno v:
Frontiers in Oncology, Vol 12 (2023)
PurposeERCC5 is a DNA endonuclease and nucleotide excision repair gene; its mutations lead to a lack of activity by this enzyme, causing oxidative DNA damage. This study aimed to assess the role of four selected single nucleotide polymorphisms (SNPs)
Externí odkaz:
https://doaj.org/article/f4b40214690a46259a0c895a31c7bdd7
Autor:
Fabio Sirchia, Ilaria Fantasia, Agnese Feresin, Elisa Giorgio, Flavio Faletra, Denise Mordeglia, Moira Barbieri, Valentina Guida, Alessandro De Luca, Tamara Stampalija
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-6 (2021)
Abstract Background Cerebro-oculo-facio-skeletal syndrome (COFS) is a severe and progressive neurologic condition characterized by prenatal onset of arthrogryposis, cataract, microcephaly and growth failure. The aim of this study was to present a cas
Externí odkaz:
https://doaj.org/article/95048ce89ad849988e515a5474966e3a
Autor:
Talita Aguiar, Anne Teixeira, Marília O. Scliar, Juliana Sobral de Barros, Renan B. Lemes, Silvia Souza, Giovanna Tolezano, Fernanda Santos, Israel Tojal, Monica Cypriano, Silvia Regina Caminada de Toledo, Eugênia Valadares, Raquel Borges Pinto, Osvaldo Afonso Pinto Artigalas, Joaquim Caetano de Aguirre Neto, Estela Novak, Lilian Maria Cristofani, Sofia M. Miura Sugayama, Vicente Odone, Isabela Werneck Cunha, Cecilia Maria Lima da Costa, Carla Rosenberg, Ana Krepischi
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The ultrarare hepatoblastoma (HB) is the most common pediatric liver cancer. HB risk is related to a few rare syndromes, and the molecular bases remain elusive for most cases. We investigated the burden of rare damaging germline variants in 30 Brazil
Externí odkaz:
https://doaj.org/article/c8e1887dc24a42b788305b61e010f668
Autor:
Jiyoun Yeo, Diego A. Morales, Tian Chen, Erin L. Crawford, Xiaolu Zhang, Thomas M. Blomquist, Albert M. Levin, Pierre P. Massion, Douglas A. Arenberg, David E. Midthun, Peter J. Mazzone, Steven D. Nathan, Ronald J. Wainz, Patrick Nana-Sinkam, Paige F. S. Willey, Taylor J. Arend, Karanbir Padda, Shuhao Qiu, Alexei Federov, Dawn-Alita R. Hernandez, Jeffrey R. Hammersley, Youngsook Yoon, Fadi Safi, Sadik A. Khuder, James C. Willey
Publikováno v:
BMC Pulmonary Medicine, Vol 18, Iss 1, Pp 1-13 (2018)
Abstract Background There is a need for more powerful methods to identify low-effect SNPs that contribute to hereditary COPD pathogenesis. We hypothesized that SNPs contributing to COPD risk through cis-regulatory effects are enriched in genes compri
Externí odkaz:
https://doaj.org/article/cb4ca686d892434394c24261efd1f94d
Akademický článek
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Publikováno v:
Clinics, Vol 73, Iss 0 (2018)
OBJECTIVES: To study the relationship between the Asp1104His polymorphism of the nucleotide excision repair gene ERCC5 and treatment sensitivity to oxaliplatin in patients with advanced colorectal cancer (CRC) in China. METHODS: A group of 226 patien
Externí odkaz:
https://doaj.org/article/249e0dbfea9c4a29a02605ad6819e181
Akademický článek
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