Zobrazeno 1 - 10
of 2 787
pro vyhledávání: '"ERAD"'
Publikováno v:
Journal of Biomedical Science, Vol 31, Iss 1, Pp 1-24 (2024)
Abstract The endoplasmic reticulum (ER) employs stringent quality control mechanisms to ensure the integrity of protein folding, allowing only properly folded, processed and assembled proteins to exit the ER and reach their functional destinations. M
Externí odkaz:
https://doaj.org/article/2bc3777e54c54136842c2c31e079c86f
Autor:
Clifford Lingwood
Publikováno v:
Lipids in Health and Disease, Vol 23, Iss 1, Pp 1-9 (2024)
Abstract Disturbances in cholesterol homeostasis have been associated with ASD. Lipid rafts are central in many transmembrane signaling pathways (including mTOR) and changes in raft cholesterol content affect their order function. Cholesterol levels
Externí odkaz:
https://doaj.org/article/a03f63242e084859ad5f017c4917d9aa
Autor:
Kaige Yang, Rongli Xie, Guohui Xiao, Zhifeng Zhao, Min Ding, Tingyu Lin, Yiu Sing Tsang, Ying Chen, Dan Xu, Jian Fei
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Acute pancreatitis (AP) is a clinically common acute abdominal disease, whose pathogenesis remains unclear. The severe patients usually have multiple complications and lack specific drugs, leading to a high mortality and poor outc
Externí odkaz:
https://doaj.org/article/86851e4a68b9419397614a6d6bc741a1
Publikováno v:
The Journal of Clinical Hypertension, Vol 26, Iss 2, Pp 197-206 (2024)
Abstract Our purpose was to develop and evaluate the clinical outcomes of a nursing plan as a rooming‐in practice for enhanced recovery of women with preeclampsia following a cesarean section. The authors developed a postoperative enhanced recovery
Externí odkaz:
https://doaj.org/article/e31b66dcd7374a669823857491e4f5f3
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
The endoplasmic reticulum (ER) is a crucial organelle that orchestrates key cellular functions like protein folding and lipid biosynthesis. However, it is highly sensitive to disturbances that lead to ER stress. In response, the unfolded protein resp
Externí odkaz:
https://doaj.org/article/f64aa9944af24eca8c01d76e2cb0d4b1
Autor:
Bowen Cao, Johanna Valentina Dahlen, Merve Sen, Tina Beyer, Tobias Leonhard, Ellen Kilger, Blanca Arango-Gonzalez, Marius Ueffing
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Dominant mutations in the rhodopsin gene (Rho) contribute to 25% of autosomal dominant retinitis pigmentosa (adRP), characterized by photoreceptor loss and progressive blindness. One such mutation, Rho∆I256, carries a 3-bp deletion, resulting in th
Externí odkaz:
https://doaj.org/article/81eff72b4092404facdca0f51106b181
Autor:
Alina Matthaei, Sebastian Joecks, Annika Frauenstein, Janina Bruening, Dorothea Bankwitz, Martina Friesland, Gisa Gerold, Gabrielle Vieyres, Lars Kaderali, Felix Meissner, Thomas Pietschmann
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 2 (2024)
ABSTRACTAssembly of infectious hepatitis C virus (HCV) particles requires multiple cellular proteins including for instance apolipoprotein E (ApoE). To describe these protein-protein interactions, we performed an affinity purification mass spectromet
Externí odkaz:
https://doaj.org/article/376bdc7a189e4ffe9567f56ee0bc03d1
Autor:
Amos Olalekan Akinyemi, Kendall Elizabeth Simpson, Sunday Faith Oyelere, Maria Nur, Chrispus Mutuku Ngule, Bolaji Charles Dayo Owoyemi, Vivian Adiila Ayarick, Felix Femi Oyelami, Oluwafunminiyi Obaleye, Dave-Preston Esoe, Xiaoqi Liu, Zhiguo Li
Publikováno v:
Molecular Medicine, Vol 29, Iss 1, Pp 1-33 (2023)
Abstract Glucose-Regulated Protein 78 (GRP78) is a chaperone protein that is predominantly expressed in the lumen of the endoplasmic reticulum. GRP78 plays a crucial role in protein folding by assisting in the assembly of misfolded proteins. Under ce
Externí odkaz:
https://doaj.org/article/14a8421fbe00410b953e5de3f8eff2ab
Autor:
Kamel Laghmani
Publikováno v:
Cells, Vol 13, Iss 10, p 818 (2024)
Mutations in NKCC2 generate antenatal Bartter syndrome type 1 (type 1 BS), a life-threatening salt-losing nephropathy characterized by arterial hypotension, as well as electrolyte abnormalities. In contrast to the genetic inactivation of NKCC2, inapp
Externí odkaz:
https://doaj.org/article/c140a4ce865c4f6894fd5ad363fe0ea9