Zobrazeno 1 - 10
of 31 119
pro vyhledávání: '"ER Stress"'
Autor:
Kento Takeuchi, Kanji Yamaguchi, Yusuke Takahashi, Kota Yano, Shinya Okishio, Hiroshi Ishiba, Nozomi Tochiki, Seita Kataoka, Hideki Fujii, Naoto Iwai, Yuya Seko, Atsushi Umemura, Michihisa Moriguchi, Takeshi Okanoue, Yoshito Itoh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract GDF15 and FGF21, stress-responsive cytokines primarily secreted from the liver, are promising therapeutic targets for metabolic dysfunction-associated steatotic liver disease (MASLD). However, the interaction between GDF15 and FGF21 remains
Externí odkaz:
https://doaj.org/article/df294e94fab24a5399ce4312726c6372
Autor:
Yiran Zhang, Xiusheng Chen, Laiqiang Chen, Mingting Shao, Wenzhen Zhu, Tingting Xing, Tingting Guo, Qingqing Jia, Huiming Yang, Peng Yin, Xiao-Xin Yan, Jiandong Yu, Shihua Li, Xiao-Jiang Li, Su Yang
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-22 (2024)
Abstract Background The activation of endoplasmic reticulum (ER) stress is an early pathological hallmark of Alzheimer’s disease (AD) brain, but how ER stress contributes to the onset and development of AD remains poorly characterized. Mesencephali
Externí odkaz:
https://doaj.org/article/20c6378e6c59460e8cba23c7081061d4
Autor:
Haibin Dong, Wenjuan Jia, Chunxiao Wang, Da Teng, Bowen Xu, Xiaoning Ding, Jun Yang, Lin Zhong, Lei Gong
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-17 (2024)
Abstract Background Myocardial ischemia/reperfusion (I/R) injury is a common pathological process in clinical practice. Developing effective therapeutic strategies to reduce or prevent this injury is crucial. The article aimed to investigate the role
Externí odkaz:
https://doaj.org/article/5395fee3b91e4b62a385e3bbcb75be52
Autor:
Dat P. Ha, Woo-Jin Shin, Ze Liu, Michael E. Doche, Roy Lau, Nektaria Maria Leli, Crystal S. Conn, Mariangela Russo, Annalisa Lorenzato, Constantinos Koumenis, Min Yu, Shannon M. Mumenthaler, Amy S. Lee
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-25 (2024)
Abstract Background Despite recent therapeutic advances, combating cancer resistance remains a formidable challenge. The 78-kilodalton glucose-regulated protein (GRP78), a key stress-inducible endoplasmic reticulum (ER) chaperone, plays a crucial rol
Externí odkaz:
https://doaj.org/article/41b097963d3a4f95bc528fc71d41ad9c
Publikováno v:
Animal Cells and Systems, Vol 28, Iss 1, Pp 481-494 (2024)
Quantum dots have diverse biomedical applications, from constructing biological infrastructures like medical imaging to advancing pharmaceutical research. However, concerns about human health arise due to the toxic potential of quantum dots based on
Externí odkaz:
https://doaj.org/article/85e6bcf702b940b5bd55b0d50418dc25
Publikováno v:
Pathophysiology, Vol 31, Iss 3, Pp 420-435 (2024)
Small GTP-binding proteins of the Rab family regulate intracellular vesicle trafficking across many aspects of the transport system. Among these, Rab9 is recognized for its role in controlling the transport system not only around the trans-Golgi netw
Externí odkaz:
https://doaj.org/article/c0202dd3fbe9489c87d87e61dd6513c9
Autor:
Ananda Baral
Publikováno v:
Stresses, Vol 4, Iss 3, Pp 481-504 (2024)
The endoplasmic reticulum (ER) is a vital cell organelle that is primarily involved in the processes of protein folding, maintenance of intracellular calcium storage and lipid synthesis in order to maintain cellular homeostasis. To achieve this metic
Externí odkaz:
https://doaj.org/article/655fd47b42ee4656975e03c80c4dd4d7
Publikováno v:
Current Issues in Molecular Biology, Vol 46, Iss 9, Pp 9342-9358 (2024)
Most neurodegenerative diseases share a common etiopathogenesis, the accumulation of protein aggregates. An imbalance in homeostasis brought on by the buildup of misfolded proteins within the endoplasmic reticulum (ER) results in ER stress in the cel
Externí odkaz:
https://doaj.org/article/0f1436b37d9f421297e80442da1d0d8b
Autor:
Laura Amodei, Anna Giulia Ruggieri, Francesca Potenza, Marianna Viele, Beatrice Dufrusine, Raffaella Franciotti, Laura Pietrangelo, Matteo Ardini, Liborio Stuppia, Luca Federici, Vincenzo De Laurenzi, Michele Sallese
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-16 (2024)
Abstract Background Marinesco-Sjögren syndrome (MSS) is an autosomal recessive neuromuscular disorder that arises in early childhood and is characterized by congenital cataracts, myopathy associated with muscle weakness, and degeneration of Purkinje
Externí odkaz:
https://doaj.org/article/ef396de560144c009f9b38bfaa55ffdc
Autor:
Azzedine Redouane-Salah, Ameddah Souad, Kerkatou Wafa, Kamil Wojnicki, Adrian Ramos, Alberto Ortiz, Bozena Kaminska, Ahmed Menad
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 27, Iss 8, Pp 1023-1032 (2024)
Objective(s): The present study aimed to explore the mechanisms underlying the potency of the renoprotective effect of the EtOAc fraction of Limonium duriusculum (EALD) (Plumbaginaceae) against cyclosporine A (CsA), in comparison to vitamin E (Vit. E
Externí odkaz:
https://doaj.org/article/e95021a5ecad44e6aa20ec6fcc638e60