Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington's disease

Autor: Josef Priller, Simone Rolfes, Ekaterini-Maria Lyras, Koliane Ouk, David A. D. Munro, Eduardo Matute, Christoph Harms, Chotima Böttcher

Publikováno v: Neurobiology of disease 144, 105024 (2020). doi:10.1016/j.nbd.2020.105024
Neurobiology of Disease, Vol 144, Iss, Pp 105024-(2020)
Rolfes, S, Munro, D, Lyras, E-M, Matute, E, Ouk, K, Harms, C, Böttcher, C & Priller, J 2020, ' Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington's disease ', Neurobiology of disease . https://doi.org/10.1016/j.nbd.2020.105024

Huntington's disease (HD) is an incurable neurodegenerative disorder caused by a trinucleotide (CAG) repeat expansion in the huntingtin gene (HTT). The R6/2 transgenic mouse model of HD expresses exon 1 of the human HTT gene with approximately 150 CA

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Potential therapeutic effects of topical recombinant human erythropoietin on burn wound healing: A preliminary randomized double-blind controlled clinical trial.

Autor: Saghafi F; Department of Clinical Pharmacy, School of Pharmacy, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran. Electronic address: f.saghafi@ssu.ac.ir., Mohammadi F; Department of Pharmaceutics, School of Pharmacy, Shahid Sadoughi University of Medical Sciences and health services, Yazd, Iran. Electronic address: mfarhad94@yahoo.com., Hoseinzade F; Pharmaceutical Sciences Research Center, School of Pharmacy, Isfahan University of Medical Sciences and health services, Isfahan, Iran. Electronic address: farahnazhoseinzade1998@gmail.com., Jafarpoor M; Pharmaceutical Sciences Research Center, School of Pharmacy, Shahid Sadoughi University of Medical Sciences and health services, Yazd, Iran. Electronic address: maryamjafarpour76@gmail.com., Manesh MJ; Department of Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: masoomehsahebnasagh@gmail.com., Sahebnasagh A; Clinical Research Center, Department of Internal Medicine, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran. Electronic address: delehsn67@yahoo.com.

Publikováno v: Burns : journal of the International Society for Burn Injuries [Burns] 2024 Dec; Vol. 50 (9), pp. 107265. Date of Electronic Publication: 2024 Sep 17.

Strenuous training combined with erythropoietin induces red cell volume expansion-mediated hypervolemia and alters systemic and skeletal muscle iron homeostasis.

Autor: Ryan BJ; Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Barney DE Jr; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.; Oak Ridge Institute for Science and Education, Belcamp, Maryland, United States., McNiff JL; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.; Combat Feeding Division, United States Army Combat Capabilities Development Command (DEVCOM), Natick, Massachusetts, United States., Drummer DJ; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.; Oak Ridge Institute for Science and Education, Belcamp, Maryland, United States., Howard EE; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Gwin JA; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Carrigan CT; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Murphy NE; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Wilson MA; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Pasiakos SM; Office of Dietary Supplements, United States Department of Health and Human Services, National Institutes of Health, Bethesda, Maryland, United States., McClung JP; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States., Margolis LM; Military Nutrition Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, United States.

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A very-low-calorie ketogenic diet normalises obesity-related enhanced levels of erythropoietin compared with a low-calorie diet or bariatric surgery.

Autor: Fernandez-Pombo A; Epigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), Travesía da Choupana Street s/n, 15706, Santiago de Compostela, La Coruna, Spain.; Endocrinology and Nutrition Division, Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), Santiago de Compostela, Spain., Lorenzo PM; Epigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), Travesía da Choupana Street s/n, 15706, Santiago de Compostela, La Coruna, Spain.; CIBER Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Madrid, Spain., Carreira MC; CIBER Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Madrid, Spain.; Molecular Endocrinology Group, Instituto de Investigacion Sanitaria de Santiago de Com-Postela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS) and Santiago de Compostela University (USC), Santiago de Compostela, Spain., Gomez-Arbelaez D; Faculty of Health Sciences, University of Santander (UDES), Bucaramanga, Colombia., Castro AI; CIBER Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Madrid, Spain.; Molecular Endocrinology Group, Instituto de Investigacion Sanitaria de Santiago de Com-Postela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS) and Santiago de Compostela University (USC), Santiago de Compostela, Spain., Primo D; Center of Investigation of Endocrinology and Nutrition, Medicine School and Department of Endocrinology and Investigation, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain., Rodriguez J; Clinical Biochemistry Laboratory, Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), Santiago de Compostela, Spain., Sajoux I; Epigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), Travesía da Choupana Street s/n, 15706, Santiago de Compostela, La Coruna, Spain.; Medical Department Pronokal Group, Barcelona, Spain., Baltar J; Division of General Surgery, Complejo Hospitalario Universitario de Santiago (CHUS/SERGAS), Santiago de Compostela, Spain., de Luis D; Center of Investigation of Endocrinology and Nutrition, Medicine School and Department of Endocrinology and Investigation, Hospital Clinico Universitario, University of Valladolid, Valladolid, Spain., Bellido D; Epigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), Travesía da Choupana Street s/n, 15706, Santiago de Compostela, La Coruna, Spain.; Endocrinology and Nutrition Unit, Complejo Hospitalario Universitario de Ferrol (CHUF/SERGAS), Ferrol, Spain., Crujeiras AB; Epigenomics in Endocrinology and Nutrition Group, Epigenomics Unit, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS/SERGAS), Travesía da Choupana Street s/n, 15706, Santiago de Compostela, La Coruna, Spain. anabelencrujeiras@hotmail.com.; CIBER Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Madrid, Spain. anabelencrujeiras@hotmail.com., Casanueva FF; CIBER Fisiopatologia de La Obesidad y Nutricion (CIBERobn), Madrid, Spain.; Molecular Endocrinology Group, Instituto de Investigacion Sanitaria de Santiago de Com-Postela (IDIS), Complejo Hospitalario Universitario de Santiago de Compostela (CHUS) and Santiago de Compostela University (USC), Santiago de Compostela, Spain.

Publikováno v: Journal of endocrinological investigation [J Endocrinol Invest] 2024 Nov; Vol. 47 (11), pp. 2701-2713. Date of Electronic Publication: 2024 May 02.