Výsledky vyhledávání

Akademický článek

Cardiomyocyte crosstalk with endothelium modulates cardiac structure, function, and ischemia-reperfusion injury susceptibility through erythropoietin

Autor: Jade P. Marrow, Razan Alshamali, Brittany A. Edgett, Melissa A. Allwood, Kyla L. S. Cochrane, Sara Al-Sabbag, Anmar Ayoub, Kjetil Ask, Gregory M. T. Hare, Keith R. Brunt, Jeremy A. Simpson

Publikováno v: Frontiers in Physiology, Vol 15 (2024)

Erythropoietin (EPO) exerts non-canonical roles beyond erythropoiesis that are developmentally, structurally, and physiologically relevant for the heart as a paracrine factor. The role for paracrine EPO signalling and cellular crosstalk in the adult

Externí odkaz: https://doaj.org/article/6990942d25af46f7b4676d92858673c8

Zobrazit plný text záznamu

Akademický článek

Possible association between a polymorphism of EPAS1 gene and persistent pulmonary hypertension of the newborn: a case-control study

Autor: Narongsak Nakwan, Surakameth Mahasirimongkol, Nusara Satproedprai, Tassamonwan Chaiyasung, Punna Kunhapan, Cheep Charoenlap, Kamonnut Singkhamanan, Chariyawan Charalsawadi

Publikováno v: Jornal de Pediatria, Vol 98, Iss 4, Pp 383-389 (2022)

Objective: To explore possible genes related to the development of persistent pulmonary hypertension of the newborn (PPHN). Methods: The authors identified 285 single nucleotide polymorphisms (SNPs) of 11 candidate genes (BMPR2, EPAS1, PDE3A, VEGFA,

Externí odkaz: https://doaj.org/article/7fdd30fb30de4594ad41ea01c3096055

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

Novel SNP of EPAS1 gene associated with higher hemoglobin concentration revealed the hypoxia adaptation of yak (Bos grunniens)

Autor: Xiao-yun WU, Xue-zhi DING, Min CHU, Xian GUO, Peng-jia BAO, Chun-nian LIANG, Ping YAN

Publikováno v: Journal of Integrative Agriculture, Vol 14, Iss 4, Pp 741-748 (2015)

Endothelial PAS domain protein 1 gene (EPAS1) is a key transcription factor that activates the expression of oxygen-regulated genes. In this study, in order to better understand the effects of EPAS1 gene on hematologic parameters in yak, we firstly q

Externí odkaz: https://doaj.org/article/1a07db6a0a344672af004514b7021366

Zobrazit plný text záznamu

Possible association between a polymorphism of EPAS1 gene and persistent pulmonary hypertension of the newborn: a case-control study

Autor: Surakameth Mahasirimongkol, Kamonnut Singkhamanan, Nusara Satproedprai, Chariyawan Charalsawadi, Punna Kunhapan, Narongsak Nakwan, Cheep Charoenlap, Tassamonwan Chaiyasung

Publikováno v: Jornal de Pediatria v.98 n.4 2022
Jornal de Pediatria
Sociedade Brasileira de Pediatria (SBP)
instacron:SBPE
Jornal de Pediatria, Volume: 98, Issue: 4, Pages: 383-389, Published: 25 JUL 2022

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb7f310a119585fc9844d75b7f2edb4
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572022000400383

Zobrazit plný text záznamu

Akademický článek

Genetic Variation of EPAS1 Gene in Tibetan Pigs and Three Low-Altitude Pig Breeds in China

Autor: Kun-zhe DONG, Ye KANG, Na YAO, Guo-tao SHU, Qing-qing ZUO, Qian-jun ZHAO, Yue-hui MA

Publikováno v: Journal of Integrative Agriculture, Vol 13, Iss 9, Pp 1990-1998 (2014)

Endothelial PAS domain protein 1 (EPAS1), also called hypoxia-inducible factor-2, is a key regulatory factor of hypoxic responses and plays an essential role in high-altitude adaptation in mammalian species. In this study, polymorphisms of EPAS1 were

Externí odkaz: https://doaj.org/article/a79b36c95c6f4f0e88f1f518254e990f

Zobrazit plný text záznamu

Integration and visualization of regulatory elements and variations of the EPAS1 gene in human

Autor: Tanja Kunej, Nataša Debeljak, Aleša Kristan

Publikováno v: Genes, vol. 12, no. 11, 1793, 2021.
Genes
Volume 12
Issue 11
Genes, Vol 12, Iss 1793, p 1793 (2021)

Endothelial PAS domain-containing protein 1 (EPAS1), also HIF2α, is an alpha subunit of hypoxia-inducible transcription factor (HIF), which mediates cellular and systemic response to hypoxia. EPAS1 has an important role in the transcription of many

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744d88cccb201763b8ef43619d22284b
https://repozitorij.uni-lj.si/IzpisGradiva.php?id=133323

Zobrazit plný text záznamu

A system-level approach identifies HIF-2α as a critical regulator of chondrosarcoma progression

Autor: Hyun Guy Kang, Yi Jun Kim, Kyoung Min Lee, Yongsik Cho, Jin-Hong Kim, Moon Jong Chang, Chong Bum Chang, Donghyeon Cheon, Hyeon Seop Kim, Hyeonkyeong Kim, Donghyun Kang, Seung Baik Kang

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications

Chondrosarcomas, malignant cartilaginous neoplasms, are capable of transitioning to highly aggressive, metastatic, and treatment-refractory states, resulting in significant patient mortality. Here, we aim to uncover the transcriptional program direct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104104dd6ec205ee4d8f0e106b06944a
http://link.springer.com/article/10.1038/s41467-020-18817-7

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Genetic variability of hypoxia‐inducible factor alpha ( HIFA ) genes in familial erythrocytosis: Analysis of the literature and genome databases

Autor: Nataša Debeljak, Tanja Kunej, Aleša Kristan

Publikováno v: European Journal of Haematology. 103:287-299

Familial erythrocytosis (FE) is a congenital disorder, defined by elevated red blood cell number, hemoglobin, and hematocrit. Among eight types of FE, type 4 is caused by variants in the EPAS1 gene. Two other hypoxia-inducible factor alpha (HIFA) sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72a4ffe63f43635743d40bb2aa0f11c
https://doi.org/10.1111/ejh.13304

Zobrazit plný text záznamu

Plný text ve formátu HTML

Vyhledávací nástroje:

Upřesnit hledání