Zobrazeno 1 - 10
of 223
pro vyhledávání: '"EPAC2"'
Publikováno v:
Neurobiology of Disease, Vol 191, Iss , Pp 106389- (2024)
Alzheimer's disease (AD) is a progressive neurodegenerative disease which accounts for the most cases of dementia worldwide. Impaired memory, including acquisition, consolidation, and retrieval, is one of the hallmarks in AD. At the cellular level, d
Externí odkaz:
https://doaj.org/article/9867825bf99448f68bf229d7984f9a75
Autor:
Wang Chuan, Li Yuan, Jiang Wen, Zeng Jianwei, Wang Caiji, Zhao Zeqi, Li Yalan, Ji Renlong, Li Kang, Li Wei, Liu Houguang, Liu Wen, Qiao Yuehua, Li Xuanyi
Publikováno v:
Brazilian Journal of Otorhinolaryngology, Vol 89, Iss 3, Pp 469-476 (2023)
Objective: To explore whether Cyclic Adenosine Monophosphate (cAMP)-Epac1 signaling is activated in 1-Desamino-8-D-arginine-Vasopressin-induced Endolymphatic Hydrops (DDAVP-induced EH) and to provide new insight for further in-depth study of DDAVP-in
Externí odkaz:
https://doaj.org/article/6a3c863aa64a4f6eaf03fb695523e98a
Autor:
Tong Zhang, Nshunge Musheshe, Christina H. J. T. M. van der Veen, Helmut W. Kessels, Amalia Dolga, Peter De Deyn, Ulrich Eisel, Martina Schmidt
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2096 (2023)
Alzheimer’s disease (AD) is one of the most prevalent neurodegenerative diseases, characterized by amyloid beta (Aβ) and hyperphosphorylated tau accumulation in the brain. Recent studies indicated that memory retrieval, rather than memory formatio
Externí odkaz:
https://doaj.org/article/2260c534bec04fd09a43fb78a12267cb
Autor:
I. A. Miroshkina, L. M. Kozhevnikova, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, S. A. Kryzhanovskii, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 30-37 (2021)
It is known that the alcoholic cardiomyopathy (ACMP) is the main reason for lethality from chronic alcoholism. For ACMP the risk of development of malignant violations of a heart rhythm which result approximately at 40% of such patients is sudden hea
Externí odkaz:
https://doaj.org/article/a6f87f8d7fc042e2a81daf443f7f900f
Autor:
Xiaojie Liu, Casey R Vickstrom, Hao Yu, Shuai Liu, Shana Terai Snarrenberg, Vladislav Friedman, Lianwei Mu, Bixuan Chen, Thomas J Kelly, David A Baker, Qing-song Liu
Publikováno v:
eLife, Vol 11 (2022)
Repeated exposure to drugs of abuse results in an upregulation of cAMP signaling in the mesolimbic dopamine system, a molecular adaptation thought to be critically involved in the development of drug dependence. Exchange protein directly activated by
Externí odkaz:
https://doaj.org/article/4b1edc7122fb42dd80a0e81a1537e41a
Autor:
Ji-Hye Kwak, You-kyung Lee, Mi-Hee Jun, Mootaek Roh, Hyunhyo Seo, Juhyun Lee, Kyungmin Lee, Jin-A Lee
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-5 (2021)
Abstract Autophagy is a lysosomal degradation pathway that regulates cellular homeostasis. It is constitutively active in neurons and controls the essential steps of neuronal development, leading to its dysfunction in neurodevelopmental disorders. Al
Externí odkaz:
https://doaj.org/article/b2a206fa59bf4cd798052868d12cdbca
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 3-17 (2020)
The review discusses modern views about the structure and functions of Epac proteins (exchange proteins directly activated by cyclic adenosine monophosphate). The involvement of Epac proteins both in the regulation of the physiological functions of t
Externí odkaz:
https://doaj.org/article/fe51a24407ed49648073b8af15afca26
Autor:
Junping Ren, Wenzhe Wu, Ke Zhang, Eun-Jin Choi, Pingyuan Wang, Teodora Ivanciuc, Alex Peniche, Youwen Qian, Roberto P. Garofalo, Jia Zhou, Xiaoyong Bao
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in young children. It is also a significant contributor to upper respiratory tract infections, therefore, a major cause for visits to the pediatrician. Hi
Externí odkaz:
https://doaj.org/article/01571f62ff98412ab6b2fd2e547fbfa1
Autor:
Hyunhyo Seo, Kyungmin Lee
Publikováno v:
Molecular Brain, Vol 12, Iss 1, Pp 1-4 (2019)
Abstract Aim cAMP signal transduction cascade activation is important in regulating neurogenesis in adult rodents by increasing the proliferation of newborn cells. Although the ventricular-subventricular zone (V-SVZ) and subgranular zone (SGZ) both c
Externí odkaz:
https://doaj.org/article/a299375eec1a47ae87842cc5f38d9a36
Autor:
Seidu A. Richard
Publikováno v:
Oncology Reviews, Vol 14, Iss 1 (2020)
Gliomas are prime brain cancers which are initiated by malignant modification of neural stem cells, progenitor cells and differentiated glial cells such as astrocyte, oligodendrocyte as well as ependymal cells. Exchange proteins directly activated by
Externí odkaz:
https://doaj.org/article/39f9558a81cc4b9e9c4a8d0c564da602