Zobrazeno 1 - 10
of 349
pro vyhledávání: '"EPAC1"'
Publikováno v:
Biochemistry and Biophysics Reports, Vol 37, Iss , Pp 101645- (2024)
Chronic pain usually lasts over three months and commonly occurs in chronic diseases (cancer, arthritis, and diabetes), injuries (herniated discs, torn ligaments), and many major pain disorders (neuropathic pain, fibromyalgia, chronic headaches). Unf
Externí odkaz:
https://doaj.org/article/1b5219903f934da1b8ab775a44c4759d
Autor:
Wang Chuan, Li Yuan, Jiang Wen, Zeng Jianwei, Wang Caiji, Zhao Zeqi, Li Yalan, Ji Renlong, Li Kang, Li Wei, Liu Houguang, Liu Wen, Qiao Yuehua, Li Xuanyi
Publikováno v:
Brazilian Journal of Otorhinolaryngology, Vol 89, Iss 3, Pp 469-476 (2023)
Objective: To explore whether Cyclic Adenosine Monophosphate (cAMP)-Epac1 signaling is activated in 1-Desamino-8-D-arginine-Vasopressin-induced Endolymphatic Hydrops (DDAVP-induced EH) and to provide new insight for further in-depth study of DDAVP-in
Externí odkaz:
https://doaj.org/article/6a3c863aa64a4f6eaf03fb695523e98a
Autor:
Joshua M Inglis, Arduino A Mangoni
Publikováno v:
eLife, Vol 12 (2023)
Blocking a protein known as EPAC1 may prevent the development of heart-related side effects caused by a chemotherapy drug.
Externí odkaz:
https://doaj.org/article/d1087eab0ca6450282bb922564d05ea5
Autor:
Marianne Mazevet, Anissa Belhadef, Maxance Ribeiro, Delphine Dayde, Anna Llach, Marion Laudette, Tiphaine Belleville, Philippe Mateo, Mélanie Gressette, Florence Lefebvre, Ju Chen, Christilla Bachelot-Loza, Catherine Rucker-Martin, Frank Lezoualch, Bertrand Crozatier, Jean-Pierre Benitah, Marie-Catherine Vozenin, Rodolphe Fischmeister, Ana-Maria Gomez, Christophe Lemaire, Eric Morel
Publikováno v:
eLife, Vol 12 (2023)
Anthracyclines, such as doxorubicin (Dox), are widely used chemotherapeutic agents for the treatment of solid tumors and hematologic malignancies. However, they frequently induce cardiotoxicity leading to dilated cardiomyopathy and heart failure. Thi
Externí odkaz:
https://doaj.org/article/cdffeb33bb6c47cd87e41bc7a93230d4
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
I. A. Miroshkina, L. M. Kozhevnikova, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, S. A. Kryzhanovskii, A. D. Durnev
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 30-37 (2021)
It is known that the alcoholic cardiomyopathy (ACMP) is the main reason for lethality from chronic alcoholism. For ACMP the risk of development of malignant violations of a heart rhythm which result approximately at 40% of such patients is sudden hea
Externí odkaz:
https://doaj.org/article/a6f87f8d7fc042e2a81daf443f7f900f
Publikováno v:
Фармакокинетика и Фармакодинамика, Vol 0, Iss 4, Pp 3-17 (2020)
The review discusses modern views about the structure and functions of Epac proteins (exchange proteins directly activated by cyclic adenosine monophosphate). The involvement of Epac proteins both in the regulation of the physiological functions of t
Externí odkaz:
https://doaj.org/article/fe51a24407ed49648073b8af15afca26
Autor:
Mehran Dehghanian, Ghafour Yarahmadi, Reyhaneh Sadat Sandoghsaz, Ali Khodadadian, Farimah Shamsi, Mohammad Yahya Vahidi Mehrjardi
Publikováno v:
Advanced Biomedical Research, Vol 12, Iss 1, Pp 101-101 (2023)
Background: Endometriosis is a female reproductive system disease in which the endometrial tissue is found in other women's organs. Various factors are effective in the development of endometriosis, and because of the interaction of genetics and envi
Externí odkaz:
https://doaj.org/article/4ab58fe95f884cf88d0d4a832a86bd82