Profiling the activity of edible European macroalgae towards pharmacological targets for type 2 diabetes mellitus

Autor: Alvaro Israel, Brian D. Green, Ciaran Fitzgerald, EP Rafferty, Danielle Calderwood, Francisco Castaneda, Brendan Gilmore, A.R.G. Wylie, Christine A. Maggs, Velizara Stoilova

Publikováno v: Calderwood, D, Rafferty, E, Fitzgerald, C, Stoilova, V, Wylie, A, Gilmore, B F, Castaneda, F, Israel, A, Maggs, C A & Green, B D 2021, ' Profiling the activity of edible European macroalgae towards pharmacological targets for type 2 diabetes mellitus ', Applied Phycology, vol. 2, no. 1, pp. 10-21 . https://doi.org/10.1080/26388081.2020.1852519

In traditional medicine marine extracts are extensively used as therapies for diabetes. With the increasing rate of incidence of type 2 diabetes mellitus and rising cost of treatments, we investigated the anti-diabetic properties of extracts of commo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e1cbaa341b57761185bd98160adbb6
https://doi.org/10.1080/26388081.2020.1852519

Investigating the effects of physiological bile acids on GLP-1 secretion and glucose tolerance in normal and GLP-1R(-/-) mice

Autor: Katharine V. Hand, EP Rafferty, A.R.G. Wylie, Christopher Elliott, David J. Grieve, Brian D. Green

Publikováno v: Rafferty, E P, Wylie, A R, Hand, K H, Elliott, C E, Grieve, D J & Green, B D 2011, ' Investigating the effects of physiological bile acids on GLP-1 secretion and glucose tolerance in normal and GLP-1R(-/-) mice ', Biological Chemistry, vol. 392, no. 6, pp. 539-546 . https://doi.org/10.1515/BC.2011.050

Physiological secretion of bile acids has previously been linked to the regulation of blood glucose. GLP-1 is an intestinal peptide hormone with important glucose-lowering actions, such as stimulation of insulin secretion and inhibition of glucagon s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7119258bb17ab07d26bcacfa49b178ec
https://pubmed.ncbi.nlm.nih.gov/21521075

Peptide based glucagon analogues are effective agents in blocking the hyperglycaemic actions of glucagon in high fat fed mice

Autor: EP Rafferty, Zara J. Franklin, Nigel Irwin, Finbarr O'Harte

Publikováno v: Regulatory Peptides. 164:32-33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac7ce3d02ffaa40eba6874e4cffce65a
https://doi.org/10.1016/j.regpep.2010.07.077

Stability and efficacy studies in N-terminally truncated glucagon receptor antagonist peptides

Autor: Finbarr O'Harte, Zara J. Franklin, Nigel Irwin, EP Rafferty

Publikováno v: Regulatory Peptides. 164:41-42

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bcaffa42296ddc68625b26b9eaaf17db
https://doi.org/10.1016/j.regpep.2010.07.106

Characterisation of structurally modified analogues of glucagon as potential glucagon receptor antagonists.

Autor: O'Harte FP; The Saad Centre for Pharmacy & Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, Co. Londonderry BT52 1SA, Northern Ireland, United Kingdom. Electronic address: fpm.oharte@ulster.ac.uk., Franklin ZJ, Rafferty EP, Irwin N

Publikováno v: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2013 Dec 05; Vol. 381 (1-2), pp. 26-34. Date of Electronic Publication: 2013 Jul 26.