Výsledky vyhledávání - "EP, Electrostatic potential"

New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography

Autor: Shawn K. Milano, Qingqiu Huang, Thuy-Tien T. Nguyen, Sekar Ramachandran, Aaron Finke, Irina Kriksunov, David J. Schuller, D. Marian Szebenyi, Elke Arenholz, Lee A. McDermott, N. Sukumar, Richard A. Cerione, William P. Katt

Publikováno v: The Journal of Biological Chemistry

Cancer cells frequently exhibit uncoupling of the glycolytic pathway from the TCA cycle (i.e., the “Warburg effect”) and as a result, often become dependent on their ability to increase glutamine catabolism. The mitochondrial enzyme Glutaminase C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa822c06b16d7fdb357d1867222ee3bf
https://pubmed.ncbi.nlm.nih.gov/34954143

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