Výsledky vyhledávání - "ENaC, epithelial sodium channel"

Liddle Syndrome due to a Novel c.1713 Deletion in the Epithelial Sodium Channel β-Subunit in a Normotensive Adolescent

Autor: BS Ida A. Ghlichloo, BS Venus Shabgahi, Daniel Elsholz, Arpita Vyas, BS Raven K. Brower, Ram K. Menon

Publikováno v: AACE Clinical Case Reports, Vol 7, Iss 1, Pp 65-68 (2021)
AACE Clinical Case Reports

Objective Liddle syndrome (LS) is a rare autosomal dominant condition secondary to a gain-of-function mutation affecting the epithelial sodium channels (ENaCs) in the distal nephron. It presents with early-onset hypertension, hypokalemia, and metabol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cdfbcecc7b0a768e67be1a91030ad5a
http://www.sciencedirect.com/science/article/pii/S237606052031018X

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SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases

Autor: Gonzalo Ferreira, Mariana Guirado, Garth L. Nicolson, Florencia Savio, Axel Santander, Luis Sobrevia

Publikováno v: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Biochimica et Biophysica Acta. Molecular Basis of Disease
Biochimica et Biophysica Acta-Molecular Basis of Disease, 1867(12):166264. ELSEVIER SCIENCE BV

Made available in DSpace on 2022-04-28T19:44:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01 Agencia Nacional de Investigación e Innovación Comisión Sectorial de Investigación Científica Fondo Nacional de Desarrollo Científico y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74138c46cacbe2627e0f4293da6b884d

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Inhibition of the epithelial sodium channel (ENaC) by connexin 30 involves stimulation of clathrin-mediated endocytosis

Autor: Alexei Diakov, Alexandr V. Ilyaskin, Christoph Korbmacher

Publikováno v: The Journal of Biological Chemistry

Mice lacking connexin 30 (Cx30) display increased epithelial sodium channel (ENaC) activity in the distal nephron and develop salt-sensitive hypertension. This indicates a functional link between Cx30 and ENaC, which remains incompletely understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba8597f1fb62923ac7ca334cd47594cf
https://pubmed.ncbi.nlm.nih.gov/33577799

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Inhibition of soluble epoxide hydrolase alleviates insulin resistance and hypertension via downregulation of SGLT2 in the mouse kidney

Autor: Yan Yang, Shuiqing Hu, Ling Tu, Yuan Yuan Li, Xizhen Xu, Jinlan Luo, Ruolan Dong, Liman Luo, Wenhua Li, Yueting Cai, Menglu Fu

Publikováno v: The Journal of Biological Chemistry

The epoxyeicosatrienoic acid (EET) exerts beneficial effects on insulin resistance and/or hypertension. EETs could be readily converted to less biological active diols by soluble epoxide hydrolase (sEH). However, whether sEH inhibition can ameliorate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db73f880c5247c207910f2017bf495dc
https://pubmed.ncbi.nlm.nih.gov/33864813

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Rational use of mucoactive medications to treat pediatric airway disease

Autor: Reinout A. Bem, Rosalie S Linssen, Jonathan Ma, Bruce K. Rubin

Publikováno v: Paediatric Respiratory Reviews

Many airway diseases in children, notably bronchiolitis, cystic fibrosis (CF), non-CF bronchiectasis including primary ciliary dyskinesia, pneumonia, and severe asthma are associated with retention of airway secretions. Medications to improve secreti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee9f096714a1e046fddce2d35c05cad
https://pubmed.ncbi.nlm.nih.gov/32653467

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Tubular lipid binding proteins (TULIPs) growing everywhere☆

Autor: Wong, Louise H., Levine, Tim P.

Publikováno v: Biochimica et Biophysica Acta

Tubular lipid binding proteins (TULIPs) have become a focus of interest in the cell biology of lipid signalling, lipid traffic and membrane contact sites. Each tubular domain has an internal pocket with a hydrophobic lining that can bind a hydrophobi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2f7179548c652055dd2120a14ae94b29
http://europepmc.org/articles/PMC5507252

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Current developments in pharmacological therapeutics for chronic constipation

Autor: Hongbin Sun, Chun-Huan Jiang, Qing-Long Xu, Xiaoan Wen

Publikováno v: Acta Pharmaceutica Sinica B, Vol 5, Iss 4, Pp 300-309 (2015)
Acta Pharmaceutica Sinica. B

Chronic constipation is a common gastrointestinal disease severely affecting the patient׳s quality of life. The traditional treatment of constipation is the use of laxatives. Recently, several new drugs including lubiprostone, linaclotide and prucal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8acc32737e6e4dc7d88cb416eee141

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The inositol phosphatase MTMR4 is a novel target of the ubiquitin ligase Nedd4

Autor: Jane Batt, Judy Correa, Pamela J. Plant, Neil M. Goldenberg, James R. Bain

Publikováno v: Biochemical Journal

The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4 (neural-precursor-cell-expressed developmentally down-regulated 4). hMTMR4 (human MTMR4) and Nedd4 co-immunoprecipita

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4439799fa09014a70381e2a7c925e750
http://europepmc.org/articles/PMC2657291

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