Zobrazeno 1 - 10
of 37
pro vyhledávání: '"EMMANUEL CHIGUTSA"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 7, Pp 1214-1223 (2024)
Abstract The objective was to characterize the pharmacokinetics (PK) and pharmacodynamics (PD) of glucagon after injectable or nasal administration and confirm the appropriate therapeutic dose of nasal glucagon (NG) for adult patients. Six clinical s
Externí odkaz:
https://doaj.org/article/da041c0a1a8748d591c4fd28f38d0670
Autor:
Ivelina Gueorguieva, Brian A. Willis, Laiyi Chua, Kay Chow, C. Steven Ernest II, Jian Wang, Sergey Shcherbinin, John R. Sims, Emmanuel Chigutsa
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 2, Pp n/a-n/a (2023)
Abstract INTRODUCTION Donanemab is an amyloid‐targeting therapy that specifically targets brain amyloid plaques. The objective of these analyses was to characterize the relationship of donanemab exposure with plasma biomarkers and clinical efficacy
Externí odkaz:
https://doaj.org/article/46f199eccdf94cd1a9b67b5c825effb4
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 6, Pp 721-730 (2022)
Abstract The relationship between severe acute respiratory syndrome‐coronavirus 2 (SARS‐CoV‐2) viral load reduction and disease symptom resolution remains largely undefined for coronavirus disease 2019 (COVID‐19). While the vaccine‐derived
Externí odkaz:
https://doaj.org/article/be2b0aade26f485a856c7e33c10b4790
Autor:
Emmanuel Chigutsa, Siva Rama Prasad Kambhampati, Amanda Karen Sykes, Maria M. Posada, Jan‐Stefan van derWalt, P. Kellie Turner
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 9, Pp 523-533 (2020)
Abemaciclib is an oral anticancer drug that inhibits cyclin dependent kinases 4 and 6 and is metabolized by cytochrome P450 3A in the intestines and liver to active metabolites. The objectives were (1) to develop a mechanistic model to characterize t
Externí odkaz:
https://doaj.org/article/aae48a8a620d4e158d398b92e2b3e234
Autor:
Paolo Denti, Kidola Jeremiah, Emmanuel Chigutsa, Daniel Faurholt-Jepsen, George PrayGod, Nyagosya Range, Sandra Castel, Lubbe Wiesner, Christian Munch Hagen, Michael Christiansen, John Changalucha, Helen McIlleron, Henrik Friis, Aase Bengaard Andersen
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141002 (2015)
Exposure to lower-than-therapeutic levels of anti-tuberculosis drugs is likely to cause selection of resistant strains of Mycobacterium tuberculosis and treatment failure. The first-line anti-tuberculosis (TB) regimen consists of rifampicin, isoniazi
Externí odkaz:
https://doaj.org/article/bbdb5010e8af410eb28c6ff6a2d531af
Publikováno v:
Pediatric Drugs. 25:377-387
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bae4c1c4cb26de2dbe0da60b55c2612
https://doi.org/10.1007/s40272-023-00565-y
https://doi.org/10.1007/s40272-023-00565-y
Autor:
Juliana M. Bue-Valleskey, Christof M. Kazda, Chenchen Ma, Jenny Chien, Qianyi Zhang, Emmanuel Chigutsa, William Landschulz, Axel Haupt, Juan P. Frias
Publikováno v:
Diabetes Care. 46:1060-1067
OBJECTIVE Basal insulin Fc (BIF) (insulin efsitora alfa; LY3209590), a fusion protein combining a novel single-chain insulin variant with a human IgG Fc domain, is designed for once-weekly basal insulin administration. This phase 2 study assessed the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::554f271b1679eb8ceb0cb386d844a4f3
https://doi.org/10.2337/dc22-2396
https://doi.org/10.2337/dc22-2396
Autor:
Christof M. Kazda, Juliana M. Bue-Valleskey, Jenny Chien, Qianyi Zhang, Emmanuel Chigutsa, William Landschulz, Paula Wullenweber, Axel Haupt, Dominik Dahl
Publikováno v:
Diabetes Care. 46:1052-1059
OBJECTIVE Basal Insulin Fc (BIF; insulin efsitora alfa; LY3209590), a fusion protein combining a novel single-chain insulin variant with a human IgG Fc domain, is designed for once-weekly basal insulin administration. This phase 2 study assessed safe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b09912fe9e31ff8d441e60a36156d404
https://doi.org/10.2337/dc22-2395
https://doi.org/10.2337/dc22-2395
Autor:
Juan Frias, Jenny Chien, Qianyi Zhang, Emmanuel Chigutsa, William Landschulz, Kristen Syring, Paula Wullenweber, Axel Haupt, Christof Kazda
Publikováno v:
The Lancet Diabetes & Endocrinology. 11:158-168
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e87310523949645e7d2466e3e59d9660
https://doi.org/10.1016/s2213-8587(22)00388-6
https://doi.org/10.1016/s2213-8587(22)00388-6
Autor:
Christof Kazda, Juliana Bue-Valleskey, Jenny Chien, Qianyi Zhang, Emmanuel Chigutsa, William Landschulz, Paula Wullenweber, Axel Haupt, Dominik Dahl, Thorsten Siegmund
Publikováno v:
Diabetologie und Stoffwechsel.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a08a02cf95c1d59ebd2fc36f61f0542
https://doi.org/10.1055/s-0043-1767949
https://doi.org/10.1055/s-0043-1767949