Zobrazeno 1 - 10
of 355
pro vyhledávání: '"EMMA E. FURTH"'
Autor:
Ning Li, Qin Zhu, Yuhua Tian, Kyung Jin Ahn, Xin Wang, Zvi Cramer, Justine Jou, Ian W. Folkert, Pengfei Yu, Stephanie Adams-Tzivelekidis, Priyanka Sehgal, Najia N. Mahmoud, Cary B. Aarons, Robert E. Roses, Andrei Thomas-Tikhonenko, Emma E. Furth, Ben Z. Stanger, Anil Rustgi, Malay Haldar, Bryson W. Katona, Kai Tan, Christopher J. Lengner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract The initiation and progression of cancer are intricately linked to the tumor microenvironment (TME). Understanding the function of specific cancer-TME interactions poses a major challenge due in part to the complexity of the in vivo microenv
Externí odkaz:
https://doaj.org/article/27a70ad4c8a74c5881020e751a7a5388
Autor:
Eleonora Scorletti, Yedidya Saiman, Sookyoung Jeon, Carolin V. Schneider, Delfin G. Buyco, Chelsea Lin, Blanca E. Himes, Clementina A. Mesaros, Marijana Vujkovic, Kate Townsend Creasy, Emma E. Furth, Jeffrey T. Billheimer, Nicholas J. Hand, David E. Kaplan, Kyong-Mi Chang, Philip S. Tsao, Julie A. Lynch, Joseph L. Dempsey, Julia Harkin, Susovon Bayen, Donna Conlon, Marie Guerraty, Michael C. Phillips, Daniel J. Rader, Rotonya M. Carr
Publikováno v:
JHEP Reports, Vol 6, Iss 1, Pp 100902- (2024)
Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is characterised by the accumulation of lipid droplets (LDs) within hepatocytes. Perilipin 2 (PLIN2) is the most abundant protein in hepatic LDs and its expression correlates with intracell
Externí odkaz:
https://doaj.org/article/0f2aac76aa174d06be32dcaf8efba46a
Autor:
Jessica Llewellyn, Caterina Fede, Abigail E. Loneker, Chet S. Friday, Michael W. Hast, Neil D. Theise, Emma E. Furth, Maria Guido, Carla Stecco, Rebecca G. Wells
Publikováno v:
JHEP Reports, Vol 5, Iss 9, Pp 100760- (2023)
Background & Aims: Glisson’s capsule is the interstitial connective tissue that surrounds the liver. As part of its normal physiology, it withstands significant daily changes in liver size. The pathophysiology of the capsule in disease is not well
Externí odkaz:
https://doaj.org/article/f72ca49d744e4847ab46882bd3e9e617
Publikováno v:
Cells, Vol 12, Iss 18, p 2256 (2023)
The Wnt signaling pathway is a highly conserved regulator of metazoan development and stem cell maintenance. Activation of Wnt signaling is an early step in diverse malignancies. Work over the past four decades has defined a “canonical” Wnt pathw
Externí odkaz:
https://doaj.org/article/c9c8aaf1f214400696a5f8322d635b7b
Autor:
Kelley Weinfurtner, Joshua Cho, Daniel Ackerman, James X. Chen, Abashai Woodard, Wuyan Li, David Ostrowski, Michael C. Soulen, Mandeep Dagli, Susan Shamimi-Noori, Jeffrey Mondschein, Deepak Sudheendra, S. William Stavropoulos, Shilpa Reddy, Jonas Redmond, Tamim Khaddash, Darshana Jhala, Evan S. Siegelman, Emma E. Furth, Stephen J. Hunt, Gregory J. Nadolski, David E. Kaplan, Terence P. F. Gade
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract In the era of precision medicine, biopsies are playing an increasingly central role in cancer research and treatment paradigms; however, patient outcomes and analyses of biopsy quality, as well as impact on downstream clinical and research a
Externí odkaz:
https://doaj.org/article/d0f2766d8b2b4876b049000c66dab279
Liver-specific ceramide reduction alleviates steatosis and insulin resistance in alcohol-fed mice[S]
Autor:
Jason Correnti, Chelsea Lin, Jascha Brettschneider, Amy Kuriakose, Sookyoung Jeon, Eleonora Scorletti, Amanke Oranu, Dru McIver-Jenkins, Isabelle Kaneza, Delfin Buyco, Yedidya Saiman, Emma E. Furth, Josepmaria Argemi, Ramon Bataller, William L. Holland, Rotonya M. Carr
Publikováno v:
Journal of Lipid Research, Vol 61, Iss 7, Pp 983-994 (2020)
Alcohol's impairment of both hepatic lipid metabolism and insulin resistance (IR) are key drivers of alcoholic steatosis, the initial stage of alcoholic liver disease (ALD). Pharmacologic reduction of lipotoxic ceramide prevents alcoholic steatosis a
Externí odkaz:
https://doaj.org/article/a511773def56488ea730bea59345852d
Autor:
Eunsun Kim, Amanda Lisby, Connie Ma, Nathanael Lo, Ursula Ehmer, Katharina E. Hayer, Emma E. Furth, Patrick Viatour
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Aberrant Wnt/b-catenin signaling is thought to be a major driver of hepatocellular carcinoma. Here, the authors show that β-Catenin is predominantly integrated within the AJ complex during the early stages of this cancer and enhance EGFR signaling t
Externí odkaz:
https://doaj.org/article/23d83511c5b14bb7b618f8c1a6766131
Autor:
Mark J. Ferreira, Lindsay B. McKenna, Jia Zhang, Maximilian Reichert, Basil Bakir, Elizabeth L. Buza, Emma E. Furth, Clifford W. Bogue, Anil K. Rustgi, Klaus H. Kaestner
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 5, Pp 550-569 (2015)
Background & Aims: Perturbations in pancreatic ductal bicarbonate secretion cause chronic pancreatitis. The physiologic mechanism of ductal secretion is known, but its transcriptional control is not. We determine the role of the transcription factor
Externí odkaz:
https://doaj.org/article/13f8248f1d774c53929ed9a3b0f1912d
Autor:
Jungsun Kim, John P. Hoffman, R. Katherine Alpaugh, Andrew D. Rhim, Maximilian Reichert, Ben Z. Stanger, Emma E. Furth, Antonia R. Sepulveda, Chao-Xing Yuan, Kyoung-Jae Won, Greg Donahue, Jessica Sands, Andrew A. Gumbs, Kenneth S. Zaret
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 2088-2099 (2013)
Pancreatic ductal adenocarcinoma (PDAC) carries a dismal prognosis and lacks a human cell model of early disease progression. When human PDAC cells are injected into immunodeficient mice, they generate advanced-stage cancer. We hypothesized that if h
Externí odkaz:
https://doaj.org/article/28f5c995ec434d528115c08678b63091
Autor:
Emma E. Furth, Karen S. Gustafson, Charlotte Y. Dai, Steven L. Gibson, Paul Menard-Katcher, Tina Chen, Jim Koh, Greg H. Enders
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 8, Iss 6, Pp 429-436 (2006)
p16INK4a is a major tumor-suppressor protein, but its regulation and settings of fuction remain poorly understood. To explore the notion that p16 is induced in vivo in response to replicative stress, we examined p16 expression in tissues from human u
Externí odkaz:
https://doaj.org/article/d9f9ddbb80d84af1adfff90997b74486