High fat diet is associated with gut microbiota dysbiosis and decreased gut microbial derived metabolites related to metabolic health in young Göttingen Minipigs.

Autor: Ditte Olsen Lützhøft, Cecilie Bækgård, Elizabeth Wimborne, Ellen Marie Straarup, Karen-Margrethe Pedersen, Jonathan R Swann, Henrik Duelund Pedersen, Kim Kristensen, Line Morgills, Dennis Sandris Nielsen, Axel Kornerup Hansen, Marianne Kronborg Bracken, Susanna Cirera, Berit Østergaard Christoffersen

Publikováno v: PLoS ONE, Vol 19, Iss 3, p e0298602 (2024)

The objectives were 1) to characterize a Göttingen Minipig model of metabolic syndrome regarding its colon microbiota and circulating microbial products, and 2) to assess whether ovariectomized female and castrated male minipigs show similar phenoty

Externí odkaz: https://doaj.org/article/90a2b8f6cca8471cb76ca51ffe9a1c22

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo.

Autor: Nidhi Gupta, Niels Fisker, Marie-Claude Asselin, Marie Lindholm, Christoph Rosenbohm, Henrik Ørum, Joacim Elmén, Nabil G Seidah, Ellen Marie Straarup

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10682 (2010)

The proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important factor in the etiology of familial hypercholesterolemia (FH) and is also an attractive therapeutic target to reduce low density lipoprotein (LDL) cholesterol. PCSK9 accelerates

Externí odkaz: https://doaj.org/article/19e6140d8bba4fac8a55f564acd212c1

1292-P: Differential Glycaemic Effects of Recombinant IL-9 across Species Highlight Translational Challenges for Immunometabolic Phenotypes

Autor: TINGQING GUO, ELLEN MARIE STRAARUP, JOSEFINE LINDROOS CHRISTENSEN, GERT BOLT, PEDER LISBY NØRBY, WANG ZHE, THOMAS A. PEDERSEN, MERCEDES FERRERAS, KRISTIAN SASS-ØRUM, KLAUS S. FREDERIKSEN

Publikováno v: Diabetes. 71

In the present study, IL-9 was initially identified as a strong regulator of blood glucose in diabetic db/db mice through a hydrodynamic gene delivery screening effort. IL-9 belongs to the common gamma-chain binding cytokine family and has classicall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77a0b625372f94c6f423e4743af3458a
https://doi.org/10.2337/db22-1292-p

FGF21 decreases food intake and body weight in obese Göttingen minipigs

Autor: Xujia Zhang, Kirsten Raun, Birgitte Andersen, Berit Ø Christoffersen, Ellen Marie Straarup, Kristian Sass-Ørum, Kirsten Lykkegaard, Johannes Josef Fels

Publikováno v: Diabetes, obesitymetabolism. 21(3)

Aims The aim of this study was to assess the effect of FGF21 on food intake, body weight, body composition, glucose homeostasis, bone mineral density (BMD), cortisol and growth hormone (GH) in obese minipigs. The pig is a unique model for studying FG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ebc28cda8681472ac332753f49c7a2
https://pubmed.ncbi.nlm.nih.gov/30328263

CD4+T-cell activation is differentially modulated by bacteria-primed dendritic cells, but is generally down-regulated by n-3 polyunsaturated fatty acids

Autor: Pia Lund, Susanne Brix, Ellen Marie Straarup, Tanja Kjær, Hanne Frøkiær, Lars Hellgren

Publikováno v: Pedersen, S B, Lund, P, Kjær, T, Straarup, E M, Hellgren, L & Frøkiær, H 2010, ' CD4+ T-cell activation is differentially modulated by bacteria-primed dendritic cells, but is generally down-regulated by n-3 polyunsaturated fatty acids ', Immunology, vol. 129, no. 3, pp. 338-350 . https://doi.org/10.1111/j.1365-2567.2009.03163.x

Appropriate activation of CD4(+) T cells is fundamental for efficient initiation and progression of acquired immune responses. Here, we showed that CD4(+) T-cell activation is dependent on changes in membrane n-3 polyunsaturated fatty acids (PUFAs) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae4e1f05afe1b3018b5cdb26405894a
https://doi.org/10.1111/j.1365-2567.2009.03163.x