Zobrazeno 1 - 10
of 464
pro vyhledávání: '"ELISABETTA DEJANA"'
Autor:
Francesca Lazzaroni, Jennifer M.T.A. Meessen, Ying Sun, Silvia Lanfranconi, Elisa Scola, Quintino Giorgio D'Alessandris, Laura Tassi, Maria Rita Carriero, Marco Castori, Silvia Marino, Adriana Blanda, Enrico B. Nicolis, Deborah Novelli, Roberta Calabrese, Nicolò M. Agnelli, Barbara Bottazzi, Roberto Leone, Selene Mazzola, Silvia Besana, Carlotta Catozzi, Luigi Nezi, Maria G. Lampugnani, Matteo Malinverno, Nastasja Grdseloff, Claudia J. Rödel, Behnam Rezai Jahromi, Niccolò Bolli, Francesco Passamonti, Peetra U. Magnusson, Salim Abdelilah-Seyfried, Elisabetta Dejana, Roberto Latini
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104914- (2024)
Summary: Background: Cerebral Cavernous Malformation (CCM) is a rare cerebrovascular disease, characterized by the presence of multiple vascular malformations that may result in intracerebral hemorrhages (ICHs), seizure(s), or focal neurological defi
Externí odkaz:
https://doaj.org/article/5d07c7a73f1a46f0b5225cf9e0e0aa36
Publikováno v:
Genes and Diseases, Vol 8, Iss 6, Pp 798-813 (2021)
The programmed cell death 10 (PDCD10) gene was originally identified as an apoptosis-related gene, although it is now usually known as CCM3, as the third causative gene of cerebral cavernous malformation (CCM). CCM is a neurovascular disease that is
Externí odkaz:
https://doaj.org/article/353f00b2bf8c4b7896e68377e8166619
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101448- (2022)
Summary: In the study of cerebral cavernous malformations (CCMs), the quantification of lesion burden is the main parameter for evaluation of disease severity and efficacy of drugs. We describe a reliable and cost-effective protocol to evaluate the n
Externí odkaz:
https://doaj.org/article/9555e4ff2d324185ab0088bbe42c1c4a
Publikováno v:
iScience, Vol 25, Iss 3, Pp 103943- (2022)
Summary: Cavernomas are multi-lumen and blood-filled vascular malformations which form in the brain and the spinal cord. They lead to hemorrhage, epileptic seizures, neurological deficits, and paresthesia. An effective medical treatment is still lack
Externí odkaz:
https://doaj.org/article/40c0ab690bcd44b2aa944c37b2e56210
Autor:
Silvia Lanfranconi, Elisa Scola, Giulio Andrea Bertani, Barbara Zarino, Roberto Pallini, Giorgio d’Alessandris, Emanuela Mazzon, Silvia Marino, Maria Rita Carriero, Emma Scelzo, Giuseppe Faragò, Marco Castori, Carmela Fusco, Antonio Petracca, Leonardo d’Agruma, Laura Tassi, Piergiorgio d’Orio, Maria Grazia Lampugnani, Enrico Bjorn Nicolis, Antonella Vasamì, Deborah Novelli, Valter Torri, Jennifer Marie Theresia Anna Meessen, Rustam Al-Shahi Salman, Elisabetta Dejana, Roberto Latini, the Treat-CCM Investigators
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-10 (2020)
Abstract Background Cerebral cavernous malformations (CCMs) are vascular malformations characterized by clusters of enlarged leaky capillaries in the central nervous system. They may result in intracranial haemorrhage, epileptic seizure(s), or focal
Externí odkaz:
https://doaj.org/article/f05152bef83d4a7394e2bd682275786c
Autor:
Matteo Malinverno, Claudio Maderna, Abdallah Abu Taha, Monica Corada, Fabrizio Orsenigo, Mariaelena Valentino, Federica Pisati, Carmela Fusco, Paolo Graziano, Monica Giannotta, Qing Cissy Yu, Yi Arial Zeng, Maria Grazia Lampugnani, Peetra U. Magnusson, Elisabetta Dejana
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Cerebral cavernous malformation is a vascular disease characterized by capillary-venous cavernomas in the central nervous system. Here the authors show that cavernomas display benign tumor characteristics and originate from the clonal expansion of mu
Externí odkaz:
https://doaj.org/article/697db73cfa424b9ba46d1f4d22882162
Autor:
Daniela A. Ferraro, Francesca Patella, Sara Zanivan, Cinzia Donato, Nicola Aceto, Monica Giannotta, Elisabetta Dejana, Maren Diepenbruck, Gerhard Christofori, Martin Buess
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background The tumour microenvironment is a critical regulator of malignant cancer progression. While endothelial cells have been widely studied in the context of tumour angiogenesis, their role as modulators of cancer cell invasion and migr
Externí odkaz:
https://doaj.org/article/d0db17bd31394cb094787352d975e11f
Autor:
Fabrizio Orsenigo, Lei Liu Conze, Suvi Jauhiainen, Monica Corada, Francesca Lazzaroni, Matteo Malinverno, Veronica Sundell, Sara Isabel Cunha, Johan Brännström, Maria Ascención Globisch, Claudio Maderna, Maria Grazia Lampugnani, Peetra Ulrica Magnusson, Elisabetta Dejana
Publikováno v:
eLife, Vol 9 (2020)
Cerebral cavernous malformation (CCM) is a rare neurovascular disease that is characterized by enlarged and irregular blood vessels that often lead to cerebral hemorrhage. Loss-of-function mutations to any of three genes results in CCM lesion formati
Externí odkaz:
https://doaj.org/article/aa53ec1c4c044b6c8163484be88191fa
Autor:
Ross O Smith, Takeshi Ninchoji, Emma Gordon, Helder André, Elisabetta Dejana, Dietmar Vestweber, Anders Kvanta, Lena Claesson-Welsh
Publikováno v:
eLife, Vol 9 (2020)
Edema stemming from leaky blood vessels is common in eye diseases such as age-related macular degeneration and diabetic retinopathy. Whereas therapies targeting vascular endothelial growth factor A (VEGFA) can suppress leakage, side-effects include v
Externí odkaz:
https://doaj.org/article/9e7f759c6eb54ac3af3a03679e04ff12
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Vascular endothelium possesses remarkable plasticity in response to cues from its surroundings, leading to great heterogeneity of endothelial cells in different vascular beds. Here the authors explain the molecular basis of endothelial plasticity dur
Externí odkaz:
https://doaj.org/article/17e23b4af4994c5abbea884369e38f4c