CircVDAC3 sequesters microRNA-592 and elevates EIF4E3 expression to inhibit the progression of gastric cancer

Autor: Tian-Ning Yang, Ruo-Wen Xiao, Fei Su, Huan-Yu Dai, Da Zhao, Chen-Hao Guo, Kai-Li Zhu, Nan Jiang, Quan-Lin Guan, Xiao-Ming Hou

Publikováno v: Translational Oncology, Vol 45, Iss , Pp 101972- (2024)

Background: Accumulating evidence has shown that circular RNAs (circRNAs) are involved in gastric cancer (GC) tumorigenesis. However, specific functional circRNAs in GC remain to be discovered, and their underlying mechanisms remain to be elucidated.

Externí odkaz: https://doaj.org/article/c9e17a4325b24dfc9328e9ee22de5fec

Trypanosoma cruzi eIF4E3- and eIF4E4-containing complexes bind different mRNAs and may sequester inactive mRNAs during nutritional stress.

Autor: Gabiatti BP; Carlos Chagas Institute, Oswaldo Cruz Foundation, FIOCRUZ, R. Prof. Algacyr Munhoz Mader 3775, 81350-010, Curitiba-PR, Brazil.; Biocenter, University of Würzburg, Am Hubland 97074, Würzburg, Germany., Freire ER; Carlos Chagas Institute, Oswaldo Cruz Foundation, FIOCRUZ, R. Prof. Algacyr Munhoz Mader 3775, 81350-010, Curitiba-PR, Brazil., Ferreira da Costa J; Carlos Chagas Institute, Oswaldo Cruz Foundation, FIOCRUZ, R. Prof. Algacyr Munhoz Mader 3775, 81350-010, Curitiba-PR, Brazil., Ferrarini MG; Laboratoire de Biométrie et Biologie Évolutive, UMR 5558, CNRS, Université de Lyon, Université Lyon 1, Villeurbanne, France., Reichert Assunção de Matos T; Carlos Chagas Institute, Oswaldo Cruz Foundation, FIOCRUZ, R. Prof. Algacyr Munhoz Mader 3775, 81350-010, Curitiba-PR, Brazil., Preti H; Carlos Chagas Institute, Oswaldo Cruz Foundation, FIOCRUZ, R. Prof. Algacyr Munhoz Mader 3775, 81350-010, Curitiba-PR, Brazil., Munhoz da Rocha I; Carlos Chagas Institute, Oswaldo Cruz Foundation, FIOCRUZ, R. Prof. Algacyr Munhoz Mader 3775, 81350-010, Curitiba-PR, Brazil., Guimarães BG; Carlos Chagas Institute, Oswaldo Cruz Foundation, FIOCRUZ, R. Prof. Algacyr Munhoz Mader 3775, 81350-010, Curitiba-PR, Brazil., Kramer S; Biocenter, University of Würzburg, Am Hubland 97074, Würzburg, Germany., Zanchin NIT; Carlos Chagas Institute, Oswaldo Cruz Foundation, FIOCRUZ, R. Prof. Algacyr Munhoz Mader 3775, 81350-010, Curitiba-PR, Brazil., Holetz FB; Carlos Chagas Institute, Oswaldo Cruz Foundation, FIOCRUZ, R. Prof. Algacyr Munhoz Mader 3775, 81350-010, Curitiba-PR, Brazil.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Dec 10. Date of Electronic Publication: 2024 Dec 10.

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Identificação de motivos relevantes para a função do fator de iniciação da tradução EIF4E3 de Leishmania sp

Autor: Moraes, Rômulo Murilo do Nascimento

Publikováno v: Repositório Institucional da FIOCRUZFundação Oswaldo CruzFIOCRUZ.

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Externí odkaz: https://www.arca.fiocruz.br/handle/icict/14341