Dialkoxyquinazolines: Screening Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Potential Tumor Imaging Probes

Autor: VanBrocklin, Henry F., Lim, John K., Coffing, Stephanie L., Hom, Darren L., Negash, Kitaw, Ono, Michele Y., Hanrahan, Stephen M., Taylor, Scott E., Vanderpoel, Jennifer L., Slavik, Sarah M., Morris, Andrew B., Riese II, David J.

Publikováno v: VanBrocklin, Henry F.; Lim, John K.; Coffing, Stephanie L.; Hom, Darren L.; Negash, Kitaw; Ono, Michele Y.; et al.(2005). Dialkoxyquinazolines: Screening Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Potential Tumor Imaging Probes. Lawrence Berkeley National Laboratory. Lawrence Berkeley National Laboratory: Lawrence Berkeley National Laboratory. Retrieved from: http://www.escholarship.org/uc/item/5bf3398t

The epidermal growth factor receptor (EGFR), a long-standing drug development target, is also a desirable target for imaging. Sixteen dialkoxyquinazoline analogs, suitable for labeling with positron-emitting isotopes, have been synthesized and evalua

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