Somatic mutations and copy number variations in breast cancers with heterogeneous HER2 amplification

Autor: Marie Colombe Agahozo, Lindy L. Visser, Winand N.M. Dinjens, Jelle Wesseling, Ronald van Marion, Esther H. Lips, Carolien H.M. van Deurzen, Peggy N. Atmodimedjo, Hein F.B.M. Sleddens, Mieke Van Bockstal

Publikováno v: Molecular Oncology
Molecular Oncology, 14(4), 671-685. John Wiley & Sons Ltd.
Molecular oncology, Vol. 14, no.4, p. 671-685 (2020)
Molecular Oncology, Vol 14, Iss 4, Pp 671-685 (2020)

Intratumour heterogeneity fuels carcinogenesis and allows circumventing specific targeted therapies. HER2 gene amplification is associated with poor outcome in invasive breast cancer. Heterogeneous HER2 amplification has been described in 5–41% of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cbecb1c8d61d18905072c1bf7c6cd4
http://europepmc.org/articles/PMC7138394

EGFR-PKM2 signaling promotes the metastatic potential of nasopharyngeal carcinoma through induction of FOSL1 and ANTXR2

Autor: Yuxiang He, Zhaoyang Zeng, Shengnan Chen, Wei Xiong, Bo Xiang, Wei Liu, Yixin Tan, Guiyuan Li, Tang Youhong, Jing Cai, Xiaoling Li, Mei Yi, Yuanyuan Ban

Publikováno v: Carcinogenesis

Nasopharyngeal carcinoma (NPC) is notorious for its aggressiveness and high metastatic potential. NPC patients with distant metastasis have a particularly poor prognosis; however, evaluating metastatic potential by expression profiles of primary tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::645e4907549be1825b4cafaa0edafb69
https://doi.org/10.1093/carcin/bgz180

Epidermal growth factor receptor intron-1 CA repeat polymorphism on protein expression and clinical outcome in Taiwanese oral squamous cell carcinoma

Autor: Chun-Ta Liao, Wen-Yu Chuang, Chih-Hsiung Lai, Hung-Ming Wang, Shiang-Fu Huang, Sou-De Cheng, Huei-Tzu Chien

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Scientific Reports

This study was designed to explore the relationship between epidermal growth factor receptor (EGFR) CA repeats polymorphism and protein expression in oral cavity squamous cell carcinoma (OSCC). A total of 194 OSCCs were examined for EGFR protein over

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fd60f06fa63f665200d76688cf160d
https://doaj.org/article/b760cba4ad5c42d0a1f836131337a9ec

Genomic Profiling of Penile Squamous Cell Carcinoma Reveals New Opportunities for Targeted Therapy

Autor: Santhoshi Bandla, Yali Zhai, Andrew S. McDaniel, Paul D. Williams, Jeffrey S. Montgomery, Chia Jen Liu, Andi K. Cani, Seth Sadis, Todd M. Morgan, Alon Z. Weizer, Javed Siddiqui, Scott A. Tomlins, Kathleen R. Cho, Ajjai Alva, Felix Y. Feng, Yajia Zhang, Rohit Mehra, Daniel R. Rhodes, Daniel H. Hovelson

Publikováno v: Cancer Research. 75:5219-5227

Penile squamous cell carcinoma (PeSCCA) is a rare malignancy for which there are limited treatment options due to a poor understanding of the molecular alterations underlying disease development and progression. Therefore, we performed comprehensive,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a62d2b6461df4286b42284002faa54a
https://doi.org/10.1158/0008-5472.can-15-1004

Immunohistochemical Localization of Wild-type EGFR, E746-A750 Frame Deletion in Exon 19, and L858R Point Mutation in Exon 21 in Triple-negative Breast Cancer

Autor: Nupur A. Patel, Hemangini H. Vora, Prushin M. Thakore, Shilin N. Shukla

Publikováno v: Applied Immunohistochemistry & Molecular Morphology. 23:653-660

AIM This study evaluated wild-type EGFR, E746-A750 frame deletion in exon 19, and L858R point mutation in exon 21 by immunohistochemistry in patients with triple-negative breast cancer (TNBC). METHODS A retrospective study included 99 untreated early

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1ad8a3b4671ca30b62c9bdf966ccb4
https://doi.org/10.1097/pai.0000000000000127