Structural alterations of the EGFR gene in glioblastoma samples as a prognostic factor and molecular target for therapy

Autor: V. O. Varachev, O. Yu. Susova, A. A. Mitrofanov, G. S. Krasnov, D. R. Naskhletashvili, Yu. I. Ammour, S. D. Bezhanova, N. V. Sevyan, E. V. Prozorenko, A. Kh. Bekyashev, T. V. Nasedkina

Publikováno v: Успехи молекулярной онкологии, Vol 11, Iss 3, Pp 68-78 (2024)

Introduction. Epidermal growth factor receptor (EGFR) is a transmembrane protein of the receptor tyrosine kinase family that is activated in various cancers (non-small cell lung cancer, colorectal cancer, head and neck tumors). In glial brain tumors,

Externí odkaz: https://doaj.org/article/c74688be09cf44c580704332ebb593c1

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A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR

Autor: Dominik Sturm, Andrey Korshunov, Andreas von Deimling, Brigitte Bison, Ales Vicha, Matija Snuderl, Nada Jabado, David Castel, Damian Stichel, Lenka Krskova, Jacques Grill, David T.W. Jones, Daniel Schrimpf, Felix Sahm, Arie Perry, Michal Zapotocky, Pieter Wesseling, Olaf Witt, Marie-Anne Debily, Stefan M. Pfister, Wolfgang Wick, David E. Reuss, Thomas S. Jacques, Jürgen Hench, Philipp Sievers, Patrick N. Harter, Guido Reifenberger, Stephan Frank, David A. Solomon, Christof M. Kramm, Martin Sill, Chris Jones

Publikováno v: Sievers, P, Sill, M, Schrimpf, D, Stichel, D, Reuss, D E, Sturm, D, Hench, J R, Frank, S, Krskova, L, Vicha, A, Zapotocky, M, Bison, B, Castel, D, Grill, J, Debily, M-A, Harter, P N, Snuderl, M, Kramm, C M, Reifenberger, G, Korshunov, A, Jabado, N, Wesseling, P, Wick, W, Solomon, D A, Perry, A, Jacques, T S, Jones, C, Witt, O, Pfister, S M, von Deimling, A, Jones, D T W & Sahm, F 2021, ' A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR ', Neuro-Oncology, vol. 23, no. 1, pp. 34-43 . https://doi.org/10.1093/neuonc/noaa251
Neuro-oncology, vol 23, iss 1
Neuro-Oncology, 23(1), 34-43. Oxford University Press
Neuro Oncol

Background Malignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense mutations in the epidermal growth factor receptor gene (EGFR) have recently been identified in a distinct s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df413ad44fc3428dc74a150c61d0d2d6
https://doi.org/10.1093/neuonc/noaa251

Comprehensive analysis of the ErbB receptor family in pediatric nervous system tumors and rhabdomyosarcoma

Autor: Manila Antonelli, Pascale Varlet, Neil W. Gibson, Carina Ittrich, Josef Rüschoff, Darren Hargrave, Ruth Ladenstein, Felice Giangaspero, Nicole C. Krämer, Michela Casanova, Claudia Bühnemann, Pilar Garin-Chesa, Norbert Schweifer, Britta Stolze, Christian Schmauch, Fatima Barbara König, Martina Uttenreuther-Fischer, Eric Bouffet, Andrew D.J. Pearson, Cynthia Hawkins, Birgit Geoerger, Flavio Solca

Publikováno v: Pediatric Blood & Cancer. 69

Background There is a paucity of knowledge regarding pediatric biomarkers, including the relevance of ErbB pathway aberrations in pediatric tumors. We investigated the occurrence of ErbB receptor aberrations across different pediatric malignancies, t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1711c23303b76c0a5b894abbbaf0201
https://doi.org/10.1002/pbc.29316

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