Výsledky vyhledávání - "EFV, efavirenz"

Approved HIV reverse transcriptase inhibitors in the past decade

Autor: Erik De Clercq, Guangdi Li, Yali Wang

Publikováno v: Acta Pharmaceutica Sinica B. 12:1567-1590

HIV reverse transcriptase (RT) inhibitors are the important components of highly active antiretroviral therapies (HAARTs) for anti-HIV treatment and pre-exposure prophylaxis in clinical practice. Many RT inhibitors and their combination regimens have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef424a5c6c813905e85108700bf093a5
https://doi.org/10.1016/j.apsb.2021.11.009

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Prolonged efavirenz exposure reduces peripheral oxytocin and vasopressin comparable to known drugs of addiction in male Sprague Dawley rats

Autor: Brian H. Harvey, Mandi Le Roux, Marisa Möller

Publikováno v: IBRO Neuroscience Reports
IBRO Neuroscience Reports, Vol 11, Iss, Pp 56-63 (2021)

Introduction Several drugs of abuse (DOA) are capable of modulating neurohypophysial hormones, such as oxytocin (OT) and vasopressin (VP), potentially resulting in the development of psychological abnormalities, such as cognitive dysfunction, psychos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae39fff547757f79eb2dc60aa152677e
https://doi.org/10.1016/j.ibneur.2021.06.003

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Development of non-nucleoside reverse transcriptase inhibitors (NNRTIs): our past twenty years

Autor: Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fen-Er Chen

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 6, Pp 961-978 (2020)

Human immunodeficiency virus (HIV) is the primary infectious agent of acquired immunodeficiency syndrome (AIDS), and non-nucleoside reverse transcriptase inhibitors (NNRTIs) are the cornerstone of HIV treatment. In the last 20 years, our medicinal ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dcf4613668fe3b2dc9c50a8c30573f
https://doi.org/10.1016/j.apsb.2019.11.010

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Improving the positional adaptability: structure-based design of biphenyl-substituted diaryltriazines as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Autor: Chunlin Zhuang, Fen-Er Chen, Ge Meng, KaiJun Jin, Erik De Clercq, Christophe Pannecouque, Minjie Liu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 2, Pp 344-357 (2020)
Acta Pharmaceutica Sinica. B

In order to improve the positional adaptability of our previously reported naphthyl diaryltriazines (NP-DATAs), synthesis of a series of novel biphenyl-substituted diaryltriazines (BP-DATAs) with a flexible side chain attached at the C-6 position is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669bcf19e6301aee51c948cba93b6a27
http://www.sciencedirect.com/science/article/pii/S2211383519301832

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Impact of obese levels on the hepatic expression of nuclear receptors and drug-metabolizing enzymes in adult and offspring mice

Autor: Liming Chen, Junjie Zhu, Lirong Zhang, Xiaochao Ma, Xueyan Shao, Pei Wang, Xiao-bo Zhong, Yifan Bao

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 171-185 (2020)
Acta Pharmaceutica Sinica. B

The prevalence of obesity-associated conditions raises new challenges in clinical medication. Although altered expression of drug-metabolizing enzymes (DMEs) has been shown in obesity, the impacts of obese levels (overweight, obesity, and severe obes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94cf0a5fdc606267df866d8be623f019
http://www.sciencedirect.com/science/article/pii/S2211383519308585

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Total thyroidectomy in HIV positive patient with buffalo hump and taurine neck

Autor: Alessandro Stefani, Uliano Morandi, Beatrice Aramini, Elena Carrese

Publikováno v: International Journal of Surgery Case Reports

Highlights • A multinodular goiter in an HIV-positive with lipodystrophy, buffalo hump and taurine neck. • Needle aspiration biopsy was difficult to use to determine the presence of lipodystrophy. • The goiter was with retrosternal engagement a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19846f9f3392e7cc098cb490e5070f9
https://hdl.handle.net/11380/1183862

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Insights into CYP2B6-mediated drug–drug interactions

Autor: Hazem E. Hassan, William D. Hedrich, Hongbing Wang

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 6, Iss 5, Pp 413-425 (2016)

Mounting evidence demonstrates that CYP2B6 plays a much larger role in human drug metabolism than was previously believed. The discovery of multiple important substrates of CYP2B6 as well as polymorphic differences has sparked increasing interest in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::036909ac63a5f48e27936e5612f420e7
https://doi.org/10.1016/j.apsb.2016.07.016

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Screening, characterisation and prevention of Hepatitis B virus (HBV) co-infection in HIV-positive children in South Africa

Autor: Pieter, Jooste, Anriette, van Zyl, Emily, Adland, Samantha, Daniels, Louise, Hattingh, Alethea, Brits, Susan, Wareing, Dominique, Goedhals, Katie, Jeffery, Monique, Andersson, Philip, Goulder, Philippa C, Matthews

Publikováno v: Journal of Clinical Virology

Background In South Africa, the first HBV vaccine dose is administered at age 6 weeks, leaving a potential window for vertical transmission. Insights into HBV seroprevalence in the vulnerable HIV-infected group are important to drive improvements in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::107c55cb6f571e42086070e2ff1d61bc
https://pubmed.ncbi.nlm.nih.gov/27838494

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PedVacc 002: A phase I/II randomized clinical trial of MVA.HIVA vaccine administered to infants born to human immunodeficiency virus type 1-positive mothers in Nairobi

Autor: Nicola Borthwick, Tomáš Hanke, Barbara Lohman-Payne, Beatrice Ondondo, Elizabeth Maleche-Obimbo, Irene N. Njuguna, Walter Jaoko, Gwen Ambler, Christine Gichuhi, Bhavna Chohan, A P Black, Shams-Rony Mehedi, Mercy Kanyugo, Grace John-Stewart, Marie Reilly, Jiyu Sun

Publikováno v: Vaccine

Highlights • MVA.HIVA vaccine was tested for the first time in HIV-1-exposed infants in Africa. • PedVacc 002 had 99% retention of infants over 48 weeks of follow-up. • MVA.HIVA was safe, but not sufficiently immunogenic. • MVA.HVA did not in

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Akademický článek

Approved HIV reverse transcriptase inhibitors in the past decade.

Autor: Li G; Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410078, China., Wang Y; Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410078, China., De Clercq E; Rega Institute for Medical Research, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven B-3000, Belgium.

Publikováno v: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2022 Apr; Vol. 12 (4), pp. 1567-1590. Date of Electronic Publication: 2021 Nov 16.

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