Altered Conformational Landscape upon Sensing Guanine Nucleotides in a Disease Mutant of Elongation Factor-like 1 (EFL1) GTPase

Autor: Jesús Pérez-Juárez, Juana Virginia Tapia-Vieyra, Gabriel Gutiérrez-Magdaleno, Nuria Sánchez-Puig

Publikováno v: Biomolecules, Vol 12, Iss 8, p 1141 (2022)

The final maturation step of the 60S ribosomal subunit requires the release of eukaryotic translation initiation factor 6 (human eIF6, yeast Tif6) to enter the pool of mature ribosomes capable of engaging in translation. This process is mediated by t

Externí odkaz: https://doaj.org/article/c6fd9514ac5346028adfa12900a853bd

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Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics

Autor: Michele Saviano, Pietro Delre, Abril Gijsbers, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Nuria Sánchez-Puig, Dritan Siliqi, Domenico Alberga

Publikováno v: Journal of Biomolecular Structure & Dynamics, 38(17), 5219-5229. Adenine Press
Journal of biomolecular structure & dynamics 37 (2019): 5219. doi:10.1080/07391102.2019.1704883
info:cnr-pdr/source/autori:Delre, Pietro; Alberga, Domenico; Gijsbers, Abril; Sanchez-Puig, Nuria; Nicolotti, Orazio; Saviano, Michele; Siliqi, Dritan; Mangiatordi, Giuseppe Felice/titolo:Exploring the role of elongation Factor-Like 1 (EFL1) in Shwachman-Diamond syndrome through molecular dynamics/doi:10.1080%2F07391102.2019.1704883/rivista:Journal of biomolecular structure & dynamics/anno:2019/pagina_da:5219/pagina_a:/intervallo_pagine:5219/volume:37

Shwachman-Diamond Syndrome (SDS) is an autosomal recessive disorder whose patients present mutations in two ribosome assembly proteins, the Shwachman-Bodian-Diamond Syndrome protein (SBDS) and the Elongation Factor-Like 1 (EFL1). Due to the lack of k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc66942bf61c3d76b6f7b456aa225c90
https://cris.maastrichtuniversity.nl/en/publications/c6dd4f37-a731-442c-ae4e-745fa9953dfb

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