Výsledky vyhledávání - "EF1, elongation factor 1"

The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene

Autor: Christian Haass, Manabu Ikeda, Frits Kamp, Kohji Mori, Dieter Edbauer, Shinji Tagami, Yuya Kawabe, Ryota Uozumi, Yoshitaka Nagai, Brigitte Nuscher, Shiho Gotoh, Tomoko Yamashita

Publikováno v: The Journal of Biological Chemistry
The journal of biological chemistry 297(4), 101120 (2021). doi:10.1016/j.jbc.2021.101120

GGGGCC (G4C2) repeat expansion in the C9orf72 gene has been shown to cause frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Dipeptide repeat proteins produced through repeat-associated non-AUG (RAN) translation are recognized as p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cf4c81b0c7b8cbc514811528f89f3b
http://europepmc.org/articles/PMC8446798

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Binding of Gtf2i-β/δ transcription factors to the ARMS2 gene leads to increased circulating HTRA1 in AMD patients and in vitro

Autor: Mao Nakayama, Subhabrata Chakrabarti, Inderjeet Kaur, Margaret M DeAngelis, Taraprasad Das, Toru Noda, Megumi Yamamoto, Daisuke Iejima, Paul N. Baird, Akiko Suga, Robyn H. Guymer, Takeshi Iwata, Yang Pan

Publikováno v: The Journal of Biological Chemistry

The disease-initiating molecular events for age-related macular degeneration (AMD), a multifactorial retinal disease affecting many millions of elderly individuals worldwide, are still unknown. Of the over 30 risk and protective loci so far associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47857712d23c3c53fbf629db43532576
https://doi.org/10.1016/j.jbc.2021.100456

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