Epigenetic silencing by SMYD3 represses tumor intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck

Autor: N Nigam, B Bernard, S Kim, K Burkitt, D Tsai, Y Robbins, C Sievers, A Clint, RL Bennett, TT Tettey, B Carter, R Bao, L Rinaldi, M.W. Lingen, H Sater, EF Edmondson, H Cheng, X Luo, K Brennan, C Chen, S Sevilla, M Murali, S Sakata, K Takeuchi, Y Nakamura, R Uppaluri, JB Sunwoo, C Van Waes, JD Licht, GL Hager, V Saloura

SUMMARYCancers often display immune escape, but the mechanisms and potential for reversibility are incompletely understood. Epigenetic dysregulation has been implicated in the immune escape of various cancer types. We have identified the epigenetic m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72cd1780ee4b9fe3bec17c47c7db15d1
https://doi.org/10.1101/2022.11.04.515098

Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.

Autor: Ridnour LA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Heinz WF; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Cheng RYS; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Wink AL; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Kedei N; Collaborative Protein Technology Resource (CPTR) Nanoscale Protein Analysis, Office of Science and Technology Resources, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Pore M; Imaging Mass Cytometry, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Imtiaz F; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Femino EL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Gonzalez AL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Coutinho LL; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.; Center for Translational Research in Oncology, ICESP/HC, Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, Brazil., Moffat RL; Optical Microscopy and Analysis Laboratory, Office of Science and Technology Resources, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Butcher D; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland., Edmondson EF; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland., Li X; Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia., Rangel MC; Center for Translational Research in Oncology, ICESP/HC, Faculdade de Medicina da Universidade de São Paulo and Comprehensive Center for Precision Oncology, Universidade de São Paulo, São Paulo, Brazil., Kinders RJ; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Rittscher J; Institute of Biomedical Engineering, Big Data Institute, Ludwig Oxford Branch, University of Oxford, Oxford, United Kingdom., Lipkowitz S; Women's Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Wong STC; Houston Methodist Neal Cancer Center, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas., Anderson SK; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., McVicar DW; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland., Glynn SA; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland., Billiar TR; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania., Chang JC; Houston Methodist Neal Cancer Center, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas., Hewitt SM; Laboratory of Pathology Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Ambs S; Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland., Lockett SJ; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland., Wink DA; Cancer Innovation Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, Maryland.

Publikováno v: Cancer research communications [Cancer Res Commun] 2024 Oct 01; Vol. 4 (10), pp. 2766-2782.

Transfer RNA acetylation regulates in vivo mammalian stress signaling.

Autor: Gamage ST; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Khoogar R; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Manage SH; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Crawford MC; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Georgeson J; Department of Molecular Genetics, Weizmann Institute of Science Rehovot 76100, Israel., Polevoda BV; Department of Biochemistry and Biophysics, Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA., Sanders C; Animal Research Technical Support, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Lee KA; Animal Research Technical Support, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Nance KD; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Iyer V; Department of Molecular Genetics, Weizmann Institute of Science Rehovot 76100, Israel., Kustanovich A; Department of Molecular Genetics, Weizmann Institute of Science Rehovot 76100, Israel., Perez M; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Thu CT; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Nance SR; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Amin R; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Miller CN; Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research (FNLCR), Frederick, MD, USA., Holewinski RJ; Protein Mass Spectrometry Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Meyer T; CCR Collaborative Bioinformatics Resource (CCBR), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, USA., Koparde V; CCR Collaborative Bioinformatics Resource (CCBR), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, USA., Yang A; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Jailwala P; CCR Collaborative Bioinformatics Resource (CCBR), Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc, Frederick, MD, USA., Nguyen JT; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Andresson T; Protein Mass Spectrometry Group, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Hunter K; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Gu S; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Mock BA; Laboratory of Cancer Biology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Edmondson EF; Molecular Histopathology Laboratory, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Difilippantonio S; Animal Research Technical Support, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Chari R; Genome Modification Core, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research (FNLCR), Frederick, MD, USA., Schwartz S; Department of Molecular Genetics, Weizmann Institute of Science Rehovot 76100, Israel., O'Connell MR; Department of Biochemistry and Biophysics, Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA., Chih-Chien Wu C; RNA Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA., Meier JL; Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 28. Date of Electronic Publication: 2024 Jul 28.

Adjuvant COX inhibition augments STING signaling and cytolytic T cell infiltration in irradiated 4T1 tumors.

Autor: Ridnour LA; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA., Cheng RY; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA., Kedei N; Collaborative Protein Technology Resource (CPTR) Nanoscale Protein Analysis, OSTR, CCR, NCI, NIH, Bethesda, Maryland, USA., Somasundaram V; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA., Bhattacharyya DD; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA., Basudhar D; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA., Wink AL; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, and., Walke AJ; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, and., Kim C; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, and., Heinz WF; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, and., Edmondson EF; Molecular Histopathology Laboratories, Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, Maryland, USA., Butcher DO; Molecular Histopathology Laboratories, Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, Maryland, USA., Warner AC; Molecular Histopathology Laboratories, Leidos Biomedical Research Inc. for the National Cancer Institute, Frederick, Maryland, USA., Dorsey TH; Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, Maryland, USA., Pore M; Imaging Mass Cytometry Frederick National Laboratory for Cancer Research, and., Kinders RJ; Office of the Director, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Frederick, Maryland, USA., Lipkowitz S; Women's Malignancy Branch CCR, NCI, NIH, Bethesda, Maryland, USA., Bryant RJ; Department of Urology, Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom., Rittscher J; Institute of Biomedical Engineering, Big Data Institute, Ludwig Oxford Branch, University of Oxford, Oxford, United Kingdom., Wong ST; Houston Methodist Neal Cancer Center, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas, USA., Hewitt SM; Laboratory of Pathology CCR, NCI, NIH, Bethesda, Maryland, USA., Chang JC; Houston Methodist Neal Cancer Center, Weill Cornell Medical College, Houston Methodist Hospital, Houston, Texas, USA., Shalaby A; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland., Callagy GM; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland., Glynn SA; Discipline of Pathology, Lambe Institute for Translational Research, School of Medicine, University of Galway, Galway, Ireland., Ambs S; Laboratory of Human Carcinogenesis, CCR, NCI, NIH, Bethesda, Maryland, USA., Anderson SK; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA.; Basic Science Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA., McVicar DW; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA., Lockett SJ; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, and., Wink DA; Cancer Innovation Laboratory, CCR, NCI, NIH, Frederick, Maryland, USA.

Publikováno v: JCI insight [JCI Insight] 2024 May 21; Vol. 9 (12). Date of Electronic Publication: 2024 May 21.

Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier.

Autor: Thomas JR; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD, 20892, USA., Frye WJE; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD, 20892, USA., Robey RW; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD, 20892, USA., Warner AC; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Butcher D; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Matta JL; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Morgan TC; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Edmondson EF; Molecular Histopathology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Salazar PB; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD, 20892, USA., Ambudkar SV; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD, 20892, USA., Gottesman MM; Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD, 20892, USA. mgottesman@nih.gov.

Publikováno v: Fluids and barriers of the CNS [Fluids Barriers CNS] 2024 Mar 15; Vol. 21 (1), pp. 27. Date of Electronic Publication: 2024 Mar 15.