Zobrazeno 1 - 10
of 45
pro vyhledávání: '"EDUARDO FERNANDEZ-REBOLLO"'
Autor:
Julia Franzen, Theodoros Georgomanolis, Anton Selich, Chao-Chung Kuo, Reinhard Stöger, Lilija Brant, Melita Sara Mulabdić, Eduardo Fernandez-Rebollo, Clara Grezella, Alina Ostrowska, Matthias Begemann, Miloš Nikolić, Björn Rath, Anthony D. Ho, Michael Rothe, Axel Schambach, Argyris Papantonis, Wolfgang Wagner
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Julia Franzen et al. investigate if changes in DNA methylation at specific genetic loci during cell culture expansion are due to a specific mechanism or gradual deregulation of an epigenetic state. Their results suggest that changes in CpG methylatio
Externí odkaz:
https://doaj.org/article/5d5f8f022ec24a2b9fe369de12508d55
Autor:
Jonathan Hollmann, Johanna Brecht, Roman Goetzke, Julia Franzen, Anton Selich, Marco Schmidt, Monika Eipel, Alina Ostrowska, Jan Hapala, Eduardo Fernandez-Rebollo, Gerhard Müller-Newen, Michael Rothe, Thomas Eggermann, Martin Zenke, Wolfgang Wagner
Publikováno v:
Stem Cell Research & Therapy, Vol 11, Iss 1, Pp 1-13 (2020)
Abstract Background The use of mesenchymal stromal cells (MSCs) for research and clinical application is hampered by cellular heterogeneity and replicative senescence. Generation of MSC-like cells from induced pluripotent stem cells (iPSCs) may circu
Externí odkaz:
https://doaj.org/article/df179f3bd39144b6b52fc3d37e4a90fc
Autor:
Eduardo Fernandez-Rebollo, Julia Franzen, Roman Goetzke, Jonathan Hollmann, Alina Ostrowska, Matteo Oliverio, Torsten Sieben, Björn Rath, Jan-Wilhelm Kornfeld, Wolfgang Wagner
Publikováno v:
Stem Cell Reports, Vol 14, Iss 2, Pp 201-209 (2020)
Summary: Long-term culture of primary cells is characterized by functional and secretory changes, which ultimately result in replicative senescence. It is largely unclear how the metabolome of cells changes during replicative senescence and if such c
Externí odkaz:
https://doaj.org/article/47438bf7e9f4475daa193be95b8bba55
Autor:
Berta Serra-Navarro, Rebeca Fernandez-Ruiz, Ainhoa García-Alamán, Marta Pradas-Juni, Eduardo Fernandez-Rebollo, Yaiza Esteban, Joan Mir-Coll, Julia Mathieu, Stephane Dalle, Max Hahn, Ulf Ahlgren, Lee S. Weinstein, Josep Vidal, Ramon Gomis, Rosa Gasa
Publikováno v:
Molecular Metabolism, Vol 53, Iss , Pp 101264- (2021)
Objective: Early postnatal life is a critical period for the establishment of the functional β-cell mass that will sustain whole-body glucose homeostasis during the lifetime. β cells are formed from progenitors during embryonic development but unde
Externí odkaz:
https://doaj.org/article/9a142fddcdd54662a98fe0baba8cb82b
Autor:
Marta Pradas-Juni, Nils R. Hansmeier, Jenny C. Link, Elena Schmidt, Bjørk Ditlev Larsen, Paul Klemm, Nicola Meola, Hande Topel, Rute Loureiro, Ines Dhaouadi, Christoph A. Kiefer, Robin Schwarzer, Sajjad Khani, Matteo Oliverio, Motoharu Awazawa, Peter Frommolt, Joerg Heeren, Ludger Scheja, Markus Heine, Christoph Dieterich, Hildegard Büning, Ling Yang, Haiming Cao, Dario F. De Jesus, Rohit N. Kulkarni, Branko Zevnik, Simon E. Tröder, Uwe Knippschild, Peter A. Edwards, Richard G. Lee, Masayuki Yamamoto, Igor Ulitsky, Eduardo Fernandez-Rebollo, Thomas Q. de Aguiar Vallim, Jan-Wilhelm Kornfeld
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Despite widespread transcription of LncRNA in mammalian systems, their contribution to metabolic homeostasis at the cellular and tissue level remains elusive. Here Pradas-Juni et al. describe a transcription factor–LncRNA pathway that couples hepat
Externí odkaz:
https://doaj.org/article/4ccddec6eb3c494894508ff7177b7683
Autor:
Elena Schmidt, Ines Dhaouadi, Isabella Gaziano, Matteo Oliverio, Paul Klemm, Motoharu Awazawa, Gerfried Mitterer, Eduardo Fernandez-Rebollo, Marta Pradas-Juni, Wolfgang Wagner, Philipp Hammerschmidt, Rute Loureiro, Christoph Kiefer, Nils R. Hansmeier, Sajjad Khani, Matteo Bergami, Markus Heine, Evgenia Ntini, Peter Frommolt, Peter Zentis, Ulf Andersson Ørom, Jörg Heeren, Matthias Blüher, Martin Bilban, Jan-Wilhelm Kornfeld
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Brown adipose tissue (BAT) thermogenesis counteracts obesity and promotes metabolic health. The role of long non-coding RNAs (lncRNAs) in the regulation of this process is not well understood. Here the authors identify a maternally expressed lncRNA,
Externí odkaz:
https://doaj.org/article/54a402f6076e4b0fbbecca1070ed468d
Autor:
Clara Grezella, Eduardo Fernandez-Rebollo, Julia Franzen, Mónica Sofia Ventura Ferreira, Fabian Beier, Wolfgang Wagner
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-6 (2018)
Abstract Background Senolytic drugs are thought to target senescent cells and might thereby rejuvenate tissues. In fact, such compounds were suggested to increase health and lifespan in various murine aging models. So far, effects of senolytic drugs
Externí odkaz:
https://doaj.org/article/a22a4039a6704a88b660d5177dbc0721
Autor:
Eduardo Fernandez-Rebollo, Birgit Mentrup, Regina Ebert, Julia Franzen, Giulio Abagnale, Torsten Sieben, Alina Ostrowska, Per Hoffmann, Pierre-François Roux, Björn Rath, Michele Goodhardt, Jean-Marc Lemaitre, Oliver Bischof, Franz Jakob, Wolfgang Wagner
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Culture medium of mesenchymal stromal cells (MSCs) is usually supplemented with either human platelet lysate (HPL) or fetal calf serum (FCS). Many studies have demonstrated that proliferation and cellular morphology are affected by these sup
Externí odkaz:
https://doaj.org/article/2212fb9151c240eb8164a2503a67027e
Autor:
Silvia Canivell, Elena G Ruano, Antoni Sisó-Almirall, Belchin Kostov, Luis González-de Paz, Eduardo Fernandez-Rebollo, Felicia A Hanzu, Marcelina Párrizas, Anna Novials, Ramon Gomis
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99310 (2014)
TCF7L2 is the susceptibility gene for Type 2 diabetes (T2D) with the largest effect on disease risk that has been discovered to date. However, the mechanisms by which TCF7L2 contributes to the disease remain largely elusive. In addition, epigenetic m
Externí odkaz:
https://doaj.org/article/5c0fc83e670f44068e6edb0cae63a396
Autor:
Silvia Canivell, Elena G Ruano, Antoni Sisó-Almirall, Belchin Kostov, Luis González-de Paz, Eduardo Fernandez-Rebollo, Felicia Hanzu, Marcelina Párrizas, Anna Novials, Ramon Gomis
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75474 (2013)
GIP action in type 2 diabetic (T2D) patients is altered. We hypothesized that methylation changes could be present in GIP receptor of T2D patients. This study aimed to assess the differences in DNA methylation profile of GIPR promoter between T2D pat
Externí odkaz:
https://doaj.org/article/38b376d325ae4f97b0c86f85380a26f8