Výsledky vyhledávání - "EDTA, ethylene diamine tetraacetic acid"

Cryopreservation of undifferentiated and differentiated human neuronal cells

Autor: Kenji Yamatoya, Yuya Nagai, Naozumi Teramoto, Woojin Kang, Kenji Miyado, Kazuya Nakata, Tohru Yagi, Yoshitaka Miyamoto

Publikováno v: Regenerative Therapy
Regenerative Therapy, Vol 19, Iss, Pp 58-68 (2022)

The effective use of human-derived cells that are difficult to freeze, such as parenchymal cells and differentiated cells from stem cells, is crucial. A stable supply of damage-sensitive cells, such as differentiated neuronal cells, neurons, and glia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05e5e2da866000a81553e84ac48fa62
https://doi.org/10.1016/j.reth.2021.12.007

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Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Autor: Yi Lu, Zhongjian Chen, Wei Wu, Pijush Kumar Paul, Quangang Zhu, Jianping Qi

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2416-2448 (2021)

Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6732d4326595a5ad29955ebaff92173
https://doi.org/10.1016/j.apsb.2021.04.001

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Molecular mechanisms of osteogenesis and antibacterial activity of Cu-bearing Ti alloy in a bone defect model with infection in vivo

Autor: Ke Yang, Min Qin, Ping zhang, Hong Xia, Yirong Chen, Hanjun Qin, Yifang Zhang, Bin Yu, Ling Ren, Jun Yang, Yu Chai

Publikováno v: Journal of Orthopaedic Translation, Vol 27, Iss, Pp 77-89 (2021)
Journal of Orthopaedic Translation

Objective The antibacterial activity of copper (Cu)-alloy biomaterials has shown a great potential in clinical application. Here, we evaluated the osteogenesis and antibacterial effects of Ti6Al4V-6.5wt%Cu alloy in an in vivo model of infected bone d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfaf85b175e6d1a33871d19af87138d
https://doi.org/10.1016/j.jot.2020.10.004

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Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates

Autor: Xin-Hui Zhang, Hong-Min Liu, Yongfang Yao, Li-Ying Ma, Xue-Jian Feng, Qin Shangshang, Tingting Yu, Bing Zhao, De-Quan Yu, Xiaoling Zhang, Ying Liu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 203-221 (2021)
Acta Pharmaceutica Sinica. B

New Delhi metallo-β-lactamase-1 (NDM-1) is capable of hydrolyzing nearly all β-lactam antibiotics, posing an emerging threat to public health. There are currently less effective treatment options for treating NDM-1 positive “superbug”, and no p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44e2471539ae24953ab00f10282f4be
http://www.sciencedirect.com/science/article/pii/S2211383520306316

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Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial

Autor: Zezhong Tian, Xiaoli Gao, Yimin Zhao, Ping Wang, Yan Yang, Kongyao Li, Lin Xu, Wenhua Ling, Yuheng Mao, Xilin Ma, Fuli Ya, Die Fan, Jinchao Zou, Yilin Shi

Publikováno v: EBioMedicine, Vol 70, Iss, Pp 103533-(2021)
EBioMedicine

BACKGROUND Dyslipidemia induces platelet hyperactivation and hyper-aggregation, which are linked to thrombosis. Anthocyanins could inhibit platelet function in vitro and in mice fed high-fat diets with their effects on platelet function in subjects w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::928a29af0270793b5ad95ae206593b50
http://www.sciencedirect.com/science/article/pii/S2352396421003261

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Luteolin promotes macrophage-mediated phagocytosis by inhibiting CD47 pyroglutamation

Autor: Xin Ge, Meiling Lu, Xiang-Huan Cui, Shilin Xu, Danni Rao, Zhiqiang Li, Wenwen Tang, Ping Wang, Lei Yu, Xuemei Gu, Xin-Yan Chen, Hong-Bing Wang, Jing Wen

Publikováno v: Translational Oncology, Vol 14, Iss 8, Pp 101129-(2021)
Translational Oncology

Highlights • Interception of CD47-SIRPα signaling is an elusive yet intriguing goal for anti-tumor immunotherapy since unbiased CD47 blockade by its antibody cannot avoid erythrocyte destruction. • We previously reported that isoQC, a Golgi-resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5277e2d46e98c8a2278b1a0984a0926
http://www.sciencedirect.com/science/article/pii/S1936523321001212

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Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CL

Autor: Yuan, Xiong, Guang-Hao, Zhu, Ya-Ni, Zhang, Qing, Hu, Hao-Nan, Wang, Hao-Nan, Yu, Xiao-Ya, Qin, Xiao-Qing, Guan, Yan-Wei, Xiang, Hui, Tang, Guang-Bo, Ge

Publikováno v: International Journal of Biological Macromolecules

Coronavirus 3C-like protease (3CLpro) is a crucial target for treating coronavirus diseases including COVID-19. Our preliminary screening showed that Ampelopsis grossedentata extract (AGE) displayed potent SARS-CoV-2-3CLpro inhibitory activity, but t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aade985145c08b4d833f2ce6ec1be30b
https://pubmed.ncbi.nlm.nih.gov/34333006

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The differential solvent exposure of N-terminal residues provides ‘fingerprints’ of alpha-synuclein fibrillar polymorphs

Autor: Maud Landureau, Stéphanie Eyquem, Tracy Bellande, Ronald Melki, Virginie Redeker

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, 2021, 296, pp.100737. ⟨10.1016/j.jbc.2021.100737⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 296, pp.100737. ⟨10.1016/j.jbc.2021.100737⟩
The Journal of Biological Chemistry

International audience; Synucleinopathies are neurodegenerative diseases characterized by the presence of intracellular deposits containing the protein alpha-synuclein (aSYN) within patients’ brains. It has been shown that aSYN can form structurall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::756ac468ece8cc57d9fe81827ca6350a

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Remote loading paclitaxel-doxorubicin prodrug into liposomes for cancer combination therapy

Autor: Guimei Lin, Xue Wang, Zhonggui He, Yongjun Wang, Dongxu Chi, Shuang Zhou, Yingli Wang, Jinbo Li, Jiamei Wang, Jiang Yu

Publikováno v: Acta Pharmaceutica Sinica B, Vol 10, Iss 9, Pp 1730-1740 (2020)
Acta Pharmaceutica Sinica. B

The combination of paclitaxel (PTX) and doxorubicin (DOX) has been widely used in the clinic. However, it remains unsatisfied due to the generation of severe toxicity. Previously, we have successfully synthesized a prodrug PTX-S-DOX (PSD). The prodru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::712aad315d89de35878a149a4a5efb69
https://pubmed.ncbi.nlm.nih.gov/33088692

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An appropriate loading control for western blot analysis in animal models of myocardial ischemic infarction

Autor: Sheng Hu, Xin Nie, Y. James Kang, Wenjing Zhang, Fulai Xue, Chen Li

Publikováno v: Biochemistry and Biophysics Reports, Vol 12, Iss C, Pp 108-113 (2017)
Biochemistry and Biophysics Reports

An appropriate loading control is critical for Western blot analysis. Housekeeping proteins (HKPs), such as β-actin, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and β-tubulin, are commonly used to normalize protein expression. But HKP express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9799ce702aae2173500233837a5e6a80
http://www.sciencedirect.com/science/article/pii/S2405580817301322

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