P601Cardio-protective effects of exercise are abolished in pressure-overload following aortic constriction by increased eNOS uncoupling and oxidative stress

Autor: An L. Moens, M. de Waard, Dirk J. Duncker, Yanti Octavia, ED Van Deel

Publikováno v: Cardiovascular Research. 103:S108.4-S108

Purpose: Cardio-protective effects of physical exercise training are generally recognized. However, previously we demonstrated that the beneficial effects of exercise critically depend on the underlying cause of cardiac dysfunction and showed that un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::012a76d58a79302991933a2f8c8d9430
https://doi.org/10.1093/cvr/cvu098.30

48Coronary microvascular dysfunction in a porcine model of familial hypercholesterolemia results in perturbations of myocardial oxygen balance at rest and during exercise

Autor: Dirk J. Duncker, MH Laughlin, Doug K Bowles, Daphne Merkus, Shawn B. Bender, Darla L. Tharp, ED Van Deel, V J De Beer

Publikováno v: Cardiovascular Research. 103:S7.2-S7

Purpose. Coronary microvascular dysfunction is increasingly recognized as a contributor to myocardial ischemia in patients with coronary artery disease. Here we investigated perturbations in the regulation of coronary resistance vessel tone and myoca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ad8501243de6eed1709e52fe390dbe1
https://doi.org/10.1093/cvr/cvu080.2

DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice.

Autor: de Boer M; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands., Te Lintel Hekkert M; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands., Chang J; Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands., van Thiel BS; Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands.; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands.; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands., Martens L; Department of Genetic Epidemiology, Institute of Human Genetics, University Hospital Münster, Münster, Germany., Bos MM; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., de Kleijnen MGJ; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands., Ridwan Y; Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands.; Department of Radiotherapy, Erasmus MC, Rotterdam, The Netherlands., Octavia Y; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands., van Deel ED; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Blonden LA; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands., Brandt RMC; Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands., Barnhoorn S; Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands., Bautista-Niño PK; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.; Centro de Investigaciones, Fundación Cardiovascular de Colombia- FCV, Bucaramanga, Colombia., Krabbendam-Peters I; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands., Wolswinkel R; Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Arshi B; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Ghanbari M; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Kupatt C; I. Medizinische Klinik und Poliklinik, University Clinic Rechts der Isar, Technical University of Munich, Munich, Germany.; DZHK (German Center for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.; Walter-Brendel-Centre for Experimental Medicine, Ludwig Maximilian University of Munich, Munich, Germany., de Windt LJ; Department of Molecular Genetics, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.; Faculty of Science and Engineering, Maastricht University, Maastricht, The Netherlands., Danser AHJ; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands., van der Pluijm I; Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands.; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands., Remme CA; Department of Clinical and Experimental Cardiology, Heart Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Stoll M; Department of Genetic Epidemiology, Institute of Human Genetics, University Hospital Münster, Münster, Germany.; Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands., Pothof J; Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands., Roks AJM; Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands., Kavousi M; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Essers J; Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands.; Department of Vascular Surgery, Erasmus MC, Rotterdam, The Netherlands.; Department of Radiotherapy, Erasmus MC, Rotterdam, The Netherlands., van der Velden J; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Hoeijmakers JHJ; Department of Molecular Genetics, Erasmus MC, Rotterdam, The Netherlands.; CECAD Forschungszentrum, Universität zu Köln, Köln, Germany.; Princess Máxima Center for Pediatric Oncology, Genome Instability and Nutrition, ONCODE Institute, Utrecht, The Netherlands., Duncker DJ; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands.

Publikováno v: Aging cell [Aging Cell] 2023 Mar; Vol. 22 (3), pp. e13768. Date of Electronic Publication: 2023 Feb 08.

Exercise Training Has Contrasting Effects in Myocardial Infarction and Pressure Overload Due to Divergent Endothelial Nitric Oxide Synthase Regulation.

Autor: van Deel ED; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, 3015GD Rotterdam, The Netherlands. e.vandeel@erasmusmc.nl., Octavia Y; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, 3015GD Rotterdam, The Netherlands. octaviayanti.md@gmail.com.; Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, 6229ER Maastricht, The Netherlands. octaviayanti.md@gmail.com., de Waard MC; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, 3015GD Rotterdam, The Netherlands. m.dewaard@erasmusmc.nl., de Boer M; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, 3015GD Rotterdam, The Netherlands. g.deboer@erasmusmc.nl., Duncker DJ; Division of Experimental Cardiology, Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, 3015GD Rotterdam, The Netherlands. d.duncker@erasmusmc.nl.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2018 Jul 06; Vol. 19 (7). Date of Electronic Publication: 2018 Jul 06.

Pregnancy mitigates cardiac pathology in a mouse model of left ventricular pressure overload.

Autor: Xu H; Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, The Netherlands; Department of Cardiac Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Peoples Republic of China;, van Deel ED; Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, The Netherlands;, Johnson MR; Academic Department of Obstetrics and Gynaecology, Imperial College London, Chelsea and Westminster Hospital, United Kingdom; and., Opić P; Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, The Netherlands;, Herbert BR; Academic Department of Obstetrics and Gynaecology, Imperial College London, Chelsea and Westminster Hospital, United Kingdom; and., Moltzer E; Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, The Netherlands; Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands., Sooranna SR; Academic Department of Obstetrics and Gynaecology, Imperial College London, Chelsea and Westminster Hospital, United Kingdom; and., van Beusekom H; Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, The Netherlands;, Zang WF; Department of Cardiac Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Peoples Republic of China;, Duncker DJ; Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, The Netherlands;, Roos-Hesselink JW; Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, The Netherlands; j.roos@erasmusmc.nl.

Publikováno v: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2016 Sep 01; Vol. 311 (3), pp. H807-14. Date of Electronic Publication: 2016 Jul 01.