ADNKA overcomes SARS-CoV2-mediated NK cell inhibition through non-spike antibodies

Autor: CA Fielding, P Sabberwal, JC Williamson, EJD Greenwood, TWM Crozier, W Zelek, J Seow, C Graham, I Huettner, JD Edgeworth, D Price, BP Morgan, K Ladell, M Eberl, IR Humphreys, B Merrick, K Doores, SJ Wilson, PJ Lehner, ECY Wang, RJ Stanton

The outcome of infection is dependent on the ability of viruses to manipulate the infected cell to evade immunity, and the ability of the immune response to overcome this evasion. Understanding this process is key to understanding pathogenesis, genet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf0a5d918f62649dcec327d6a21d9f50
https://doi.org/10.1101/2021.04.06.438630

PIN17: THE VALUE OF VACCINATING INFANTS AND CHILDREN WITH PNEUMOCOCCAL CONJUGATE VACCINE

Autor: MW Ford, Ecy Wang

Publikováno v: Value in Health. (3):256-257

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32614f5e217da02e17378de3fd9c2a8

Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function.

Autor: Kite J; Section of Virology, Department of Microbial Sciences, School of Biosciences, University of Surrey, Guildford GU2 7XH, UK.; Present address: Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK., Hill M; Section of Virology, Department of Microbial Sciences, School of Biosciences, University of Surrey, Guildford GU2 7XH, UK., Preston N; Section of Virology, Department of Microbial Sciences, School of Biosciences, University of Surrey, Guildford GU2 7XH, UK., Rubina A; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Kollnberger S; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Wang ECY; Division of Infection & Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Elliott G; Section of Virology, Department of Microbial Sciences, School of Biosciences, University of Surrey, Guildford GU2 7XH, UK.

Publikováno v: The Journal of general virology [J Gen Virol] 2024 Mar; Vol. 105 (3).

ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways.

Autor: Rubina A; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Patel M; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Nightingale K; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom., Potts M; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom., Fielding CA; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Kollnberger S; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Lau B; Centre for Virus Research, University of Glasgow, Glasgow G12 8TA, United Kingdom., Ladell K; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Miners KL; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Nichols J; Centre for Virus Research, University of Glasgow, Glasgow G12 8TA, United Kingdom., Nobre L; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom., Roberts D; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Trinca TM; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Twohig JP; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Vlahava VM; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Davison AJ; Centre for Virus Research, University of Glasgow, Glasgow G12 8TA, United Kingdom., Price DA; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Tomasec P; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Wilkinson GWG; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Weekes MP; Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, United Kingdom.; Department of Medicine, University of Cambridge, Cambridge CB2 0XY, United Kingdom., Stanton RJ; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom., Wang ECY; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Aug 15; Vol. 120 (33), pp. e2303155120. Date of Electronic Publication: 2023 Aug 10.

Quantitative proteomic analysis of SARS-CoV-2 infection of primary human airway ciliated cells and lung epithelial cells demonstrates the effectiveness of SARS-CoV-2 innate immune evasion.

Autor: Crozier TWM; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK., Greenwood EJD; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK., Williamson JC; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK., Guo W; Department of Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK., Porter LM; Department of Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK., Gabaev I; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK., Teixeira-Silva A; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK., Grice GL; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK., Wickenhagen A; MRC - University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK., Stanton RJ; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK., Wang ECY; Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK., Wilson SJ; MRC - University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, UK., Matheson NJ; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK.; NHS Blood and Transplant, Cambridge, CB2 0PT, UK., Nathan JA; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK., McCaughan F; Department of Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK., Lehner PJ; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, CB2 0AW, UK.

Publikováno v: Wellcome open research [Wellcome Open Res] 2022 Sep 07; Vol. 7, pp. 224. Date of Electronic Publication: 2022 Sep 07 (Print Publication: 2022).