A step-by-step approach for assessing acute oral toxicity without animal testing for additives of quasi-drugs and cosmetic ingredients

Autor: Hajime Kojima, Tokio Nakada, Akiko Yagami, Hiroaki Todo, Jihei Nishimura, Mio Yagi, Keiko Yamamoto, Mariko Sugiyama, Yoshiaki Ikarashi, Hitoshi Sakaguchi, Masahiko Yamaguchi, Morihiko Hirota, Sakiko Aizawa, Shota Nakagawa, Shigenobu Hagino, Masato Hatao

Publikováno v: Current Research in Toxicology, Vol 4, Iss , Pp 100100- (2023)

Animal testing of cosmetic ingredients and products has been banned in the European Union since 2013. However, in Japan, the application of new quasi-drugs requires the generation of data on acute oral toxicity through animal testing. A weight of evi

Externí odkaz: https://doaj.org/article/87dee5b26ae9496ab51c2bcc9ad2ae5d

Quantification of the Ecological Value of Railroad Development Areas Using Logistic Regression Analysis

Autor: Min-Kyeong Kim, Dong-Yeob Kim, Duckshin Park

Publikováno v: International Journal of Environmental Research and Public Health
Volume 18
Issue 22
International Journal of Environmental Research and Public Health, Vol 18, Iss 11764, p 11764 (2021)

According to the national railway network construction plan, Investment in railways has increased due to the need for environmentally friendly transportation, and the rail network is expanding throughout South Korea. Railway projects should be evalua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1df9baabc349d69dcc923d06f75a5d

EURL ECVAM Genotoxicity and Carcinogenicity Database of Substances Eliciting Negative Results in the Ames Test: Construction of the Database

Autor: Paul D. White, David Asturiol, Takeshi Morita, Raffaella Corvi, David Kirkland, Federica Madia

Publikováno v: Mutation Research. Genetic Toxicology and Environmental Mutagenesis

Highlights • EURL ECVAM Consolidated Genotoxicity and Carcinogenicity Database extended. • Negative Ames test results were compiled and reviewed. • A database of Ames negative results was constructed. • Database chemical space characterizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f35f7f2c0d3d7d8ea5e7b4925cce7b
http://europepmc.org/articles/PMC7374420

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Acute toxicity studies of the South African medicinal plant

Autor: Tiza, Ng'uni, Jeremy A, Klaasen, Burtram C, Fielding

Publikováno v: Toxicology Reports

Graphical abstract
Highlights • G. africana LD50 was over 2000 mg/kgbw for acute oral and dermal toxicity studies. • G. africana was non-irritant on the reconstituted human epidermis models. • Open application of extract at various concent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b5edd579dc7c5e38eb416bde6a356f4e
https://pubmed.ncbi.nlm.nih.gov/30128298