Zobrazeno 1 - 10
of 1 249
pro vyhledávání: '"ECM–extracellular matrix"'
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Tumor-associated macrophages (TAMs), fundamental constituents of the tumor microenvironment (TME), significantly influence cancer development, primarily by promoting epithelial-mesenchymal transition (EMT). EMT endows cancer cells with increased moti
Externí odkaz:
https://doaj.org/article/5181cfe6c6524cf78497e78f84773d76
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Externí odkaz:
https://doaj.org/article/9c535efc690a4560a96605e578d79cbc
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
It has been known for decades that the tumor extracellular matrix (ECM) is dysfunctional leading to loss of tissue architecture and promotion of tumor growth. The altered ECM and tumor fibrogenesis leads to tissue stiffness that act as a physical bar
Externí odkaz:
https://doaj.org/article/f18f4fb63fd74d4aaf0dd5c1f40c603d
Autor:
Dan Liang, Lu Liu, Yunjie Zhao, Zhenyi Luo, Yadi He, Yanping Li, Shiyun Tang, Jianyuan Tang, Nianzhi Chen
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Extracellular matrix (ECM) plays a pivotal and dynamic role in the construction of tumor microenvironment (TME), becoming the focus in cancer research and treatment. Multiple cell signaling in ECM remodeling contribute to uncontrolled proliferation,
Externí odkaz:
https://doaj.org/article/a3e4008dbd7746c8ae99bcf743fbeaef
Autor:
Subhajit Konar, Scott M. Bolam, Brendan Coleman, Nicola Dalbeth, Sue R. McGlashan, Sophia Leung, Jillian Cornish, Dorit Naot, David S. Musson
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Tendinopathy is characterised by pathological changes in tendon matrix composition, architecture, and stiffness, alterations in tendon resident cell characteristics, and fibrosis, with inflammation also emerging as an important factor in tendinopathy
Externí odkaz:
https://doaj.org/article/bf4f312d8a9d46f681f0ca26cddf7c38
Autor:
Nan Li, Shan Shan, Xiu-Qin Li, Ting-Ting Chen, Meng Qi, Sheng-Nan Zhang, Zi-Ying Wang, Ling-Ling Zhang, Wei Wei, Wu-Yi Sun
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
G protein-coupled receptor kinase 2 (GRK2), an important subtype of GRKs, specifically phosphorylates agonist-activated G protein-coupled receptors (GPCRs). Besides, current research confirms that it participates in multiple regulation of diverse cel
Externí odkaz:
https://doaj.org/article/40834aff4d454f3f8b9d8a6e12e781fe
Autor:
Georgii Vasiukov, Tatiana Novitskaya, Maria-Fernanda Senosain, Alex Camai, Anna Menshikh, Pierre Massion, Andries Zijlstra, Sergey Novitskiy
Publikováno v:
Frontiers in Bioinformatics, Vol 1 (2021)
Modern technologies designed for tissue structure visualization like brightfield microscopy, fluorescent microscopy, mass cytometry imaging (MCI) and mass spectrometry imaging (MSI) provide large amounts of quantitative and spatial information about
Externí odkaz:
https://doaj.org/article/29041d8a47c14a7fbda334f76f3e2568
Autor:
Saskia V. Vijver, Akashdip Singh, Eline T. A. M. Mommers-Elshof, Jan Meeldijk, Ronald Copeland, Louis Boon, Sol Langermann, Dallas Flies, Linde Meyaard, M. Inês Pascoal Ramos
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The tumor microenvironment (TME) is a complex structure comprised of tumor, immune and stromal cells, vasculature, and extracellular matrix (ECM). During tumor development, ECM homeostasis is dysregulated. Collagen remodeling by matrix metalloprotein
Externí odkaz:
https://doaj.org/article/3c1e42c2d3424fdd8a18513ad402dbae
Publikováno v:
FEBS Open Bio, Vol 9, Iss 4, Pp 755-768 (2019)
Liver cirrhosis (LC) is a disease characterized by pathological accumulation and alteration of extracellular matrix (ECM) proteins; the interaction between two such proteins, collagen and vitronectin (VN), is considered to be the key to controlling E
Externí odkaz:
https://doaj.org/article/732ada7d281b4654802b3107ecc321b4
Autor:
Tanvi Karnik, Sandi G. Dempsey, Micheal J. Jerram, Arun Nagarajan, Ravindra Rajam, Barnaby C. H. May, Christopher H. Miller
Publikováno v:
Biomaterials Research, Vol 23, Iss 1, Pp 1-17 (2019)
Abstract Background Antimicrobial technologies, including silver-containing medical devices, are increasingly utilized in clinical regimens to mitigate risks of microbial colonization. Silver-functionalized resorbable biomaterials for use in wound ma
Externí odkaz:
https://doaj.org/article/795ca13b48d04df39afaf4783eab7c29