Výsledky vyhledávání - "ECL, enhanced chemiluminescence"

A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer

Autor: Yun Dai, Zhuo Yu, Dandan Sun, Hao Yang, Liu Song, Shulan Han, Caitriona M. O'Driscoll, Jianfeng Guo, Di Chu, Jie Ma, Yifang Zou

Publikováno v: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 378-393 (2022)
Acta Pharmaceutica Sinica. B

The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer (CRC). Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee6dd4b7090c45d73c9ae54ee9fd9f2
http://www.sciencedirect.com/science/article/pii/S2211383521002173

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RUNX3 derived hsa_circ_0005752 accelerates the osteogenic differentiation of adipose-derived stem cells via the miR-496/MDM2-p53 pathway

Autor: Yifan Huan, Ming Wang, Jing Li, Guohua Lv, Xiyang Li

Publikováno v: Regenerative Therapy
Regenerative Therapy, Vol 18, Iss, Pp 430-440 (2021)

Background Circular RNAs (circRNAs) are non-coding RNAs that play a pivotal role in bone diseases. RUNX3 was an essential transcriptional regulator during osteogenesis. However, it is unknown whether RUNX3 regulates hsa_circ_0005752 during osteogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0747b3ae95e6dcf1917df04284706e77
http://europepmc.org/articles/PMC8546365

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Functional metabolomics reveal the role of AHR/GPR35 mediated kynurenic acid gradient sensing in chemotherapy-induced intestinal damage

Autor: Chuyao Liao, Di Wang, Ying Zhang, Zunjian Zhang, Fengguo Xu, Siyuan Qin, Yuxin Zhang, Danting Li, Yuan Tian, Jie Chen

Publikováno v: Acta Pharmaceutica Sinica B, Vol 11, Iss 3, Pp 763-780 (2021)
Acta Pharmaceutica Sinica. B

Intestinal toxicity induced by chemotherapeutics has become an important reason for the interruption of therapy and withdrawal of approved agents. In this study, we demonstrated that chemotherapeutics-induced intestinal damage were commonly character

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af930bc5ea3c9fbae9d582539b35a5f
https://doi.org/10.1016/j.apsb.2020.07.017

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Fraxetin inhibits interleukin-1β-induced apoptosis, inflammation, and matrix degradation in chondrocytes and protects rat cartilage in vivo

Autor: Bitao Ma, Di Zhuang, Qing Wang, Lilun Jin, Wenchang Feng, Liping Qin

Publikováno v: Saudi Pharmaceutical Journal, Vol 28, Iss 12, Pp 1499-1506 (2020)
Saudi Pharmaceutical Journal : SPJ

Osteoarthritis (OA) is a disease characterized by degeneration of the joint complex due to cartilage destruction. Fraxetin, a widely used and studied coumarin compound extracted from a traditional Chinese herb (Qin Pi), has shown anti-inflammatory an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e983a5ffbb58806e56a84e82964e7f0
http://www.sciencedirect.com/science/article/pii/S1319016420302218

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Miltirone induces cell death in hepatocellular carcinoma cell through GSDME-dependent pyroptosis

Autor: Ping Zhang, Dingyuan Ma, Li-Ying Peng, Ning-Yuan Sun, Jun Chen, Xiao-Wei Zhang, Weiwei Tang, Lin An

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 10, Iss 8, Pp 1397-1413 (2020)

Pyroptosis is a form of programmed cell death, and recently described as a new molecular mechanism of chemotherapy drugs in the treatment of tumors. Miltirone, a derivative of phenanthrene-quinone isolated from the root of Salvia miltiorrhiza Bunge,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750fb5bad337ad6389f2c3000e4927a2
http://europepmc.org/articles/PMC7488361

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Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire

Autor: Andrew M. Gulick, Ketan D. Patel

Publikováno v: The Journal of Biological Chemistry

The fungal cyclohexadepsipeptides destruxins (DTXs), isaridins (ISDs), and isariins (ISRs) are nonribosomal peptides whose structures include a 19-membered ring composed of five amino acid residues and one α- or β-hydroxy acid residue. These cycloh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db8d8ca31ca8887f2d560258e929090c
https://pubmed.ncbi.nlm.nih.gov/34029593

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Hypocrellin A-based photodynamic action induces apoptosis in A549 cells through ROS-mediated mitochondrial signaling pathway

Autor: Shu-Qin Yu, Shuang-Lin Chen, Ling-Yuan Guo, Robert J. Lee, Shan-Shan Qi, Shu-Zhen Yan

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 2, Pp 279-293 (2019)

Over recent decades, many studies have reported that hypocrellin A (HA) can eliminate cancer cells with proper irradiation in several cancer cell lines. However, the precise molecular mechanism underlying its anticancer effect has not been fully defi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234a255e7495bc3248845012723dbc6e
https://doi.org/10.1016/j.apsb.2018.12.004

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FOXO3a inhibits the EMT and metastasis of breast cancer by regulating TWIST-1 mediated miR-10b/CADM2 axis

Autor: Xi Zhang, Long Jin, Hui-Qun Fu, Yuliang Pan, Jun Zhang

Publikováno v: Translational Oncology
Translational Oncology, Vol 14, Iss 7, Pp 101096-(2021)

Highlights • FOXO3a was down-regulated and TWIST-1 was up-regulated in breast cancer tissues. • Overexpression of FOXO3a suppressed the EMT and metastasis of breast cancer. • Knockdown of TWIST-1 inhibited the EMT and metastasis of breast cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70df0f04d470a09d0748c1247de8c9bc
http://europepmc.org/articles/PMC8081990

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Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation

Autor: Minju Hyun, Joongkyu Park, Eunju Im, Ye Hyung Lee, Kwang Chul Chung

Publikováno v: The Journal of Biological Chemistry

Down syndrome (DS) is mainly caused by an extra copy of chromosome 21 (trisomy 21), and patients display a variety of developmental symptoms, including characteristic facial features, physical growth delay, intellectual disability, and neurodegenerat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb46a6897b43680c3b5e7eb119fa1fa8
http://europepmc.org/articles/PMC7948726

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ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway

Autor: Guohua Chen, Aaron Lotvola, Jian Wang, James G. Granneman, Guoli Zhou

Publikováno v: The Journal of Biological Chemistry

ABHD5 is an essential coactivator of ATGL, the rate-limiting triglyceride (TG) lipase in many cell types. Importantly, ABHD5 also functions as a tumor suppressor, and ABHD5 mRNA expression levels correlate with patient survival for several cancers. N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deaaef2a49347dd97933999077b7b042
https://pubmed.ncbi.nlm.nih.gov/33219129

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