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The association between genetically elevated polyunsaturated fatty acids and risk of cancer

Autor: Haycock, Philip C, Borges, Maria Carolina, Burrows, Kimberley, Lemaitre, Rozenn N, Burgess, Stephen, Khankari, Nikhil K, Tsilidis, Konstantinos K, Gaunt, Tom R, Hemani, Gibran, Zheng, Jie, Truong, Therese, Birmann, Brenda M, OMara, Tracy, Spurdle, Amanda B, Iles, Mark M, Law, Matthew H, Slager, Susan L, Saberi Hosnijeh, Fatemeh, Mariosa, Daniela, Cotterchio, Michelle, Cerhan, James R, Peters, Ulrike, Enroth, Stefan, Gharahkhani, Puya, Le Marchand, Loic, Williams, Ann C, Block, Robert C, ACCC, CCFR-CORECT-GECCO, EPITHYR, InterLymph, MMAC, ECAC, ILCCO, PRACTICAL Consortium, PanScan, PanC4, Amos, Christopher I, Hung, Rayjean J, Zheng, Wei, Gunter, Marc J, Smith, George Davey, Relton, Caroline, Martin, Richard M, Fatty Acids in Cancer Mendelian Randomization Collaboration

BACKGROUND: The causal relevance of polyunsaturated fatty acids (PUFAs) for risk of site-specific cancers remains uncertain. METHODS: Using a Mendelian randomization (MR) framework, we assessed the causal relevance of PUFAs for risk of cancer in Euro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______109::ebfca62874c661f67eebb2bebd9149d8
https://www.repository.cam.ac.uk/handle/1810/349993

Genetically Raised Circulating Bilirubin Levels and Risk of Ten Cancers: A Mendelian Randomization Study

Autor: Seyed Khoei, Nazlisadat, Carreras Torres, Robert, Murphy, Neil, Gunter, Marc J., Brennan, Paul, Smith-Byrne, Karl, Mariosa, Daniela, McKay, James D., O’Mara, Tracy, Jarrett, Ruth, Hjalgrim, Henrik, Smedby, Karin E., Cozen, Wendy, Onel, Kenan, Diepstra, Arjan, Wagner, Karl-Heinz, Freisling, Heinz, ECAC Group

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona

Bilirubin, an endogenous antioxidant, may play a protective role in cancer development. We applied two-sample Mendelian randomization to investigate whether genetically raised bilirubin levels are causally associated with the risk of ten cancers (pan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2fca3dc4a32e409887eff10a43b9cda9
http://hdl.handle.net/2445/175497

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers

Autor: Montserrat Garcia-Closas, Ellen L. Goode, Mark M. Iles, Brian M. Wolpin, Stephen J. Chanock, Susan L. Slager, Li Hsu, Clare Turnbull, Ccfr, Michael Hoffmeister, Peter T. Campbell, Maria Teresa Landi, Paul D.P. Pharoah, Amber N. Hurson, Melissa L. Bondy, Roger L. Milne, Peter A. Kanetsky, Simon A. Gayther, Christopher A. Haiman, Nicola J. Camp, Mark A. Jenkins, Margaret Wrensch, Bcac, Ulrike Peters, Jill S. Barnholtz-Sloan, Richard S. Houlston, PanScan, Haoyu Zhang, Christopher I. Amos, Ben Kinnersley, GenoMEL, Florence Demenais, Rosalind A. Eeles, Katherine A. McGlynn, Practical, John K. Wiencke, Gicc, Katherine L. Nathanson, Stolzenberg-Solomon R, Brenda M. Birmann, Rayjean J. Hung, Donghui Li, David C. Whiteman, Ghislaine Scelo, Sonja I. Berndt, Alison P. Klein, Sarah V. Ward, Per Hall, D. Timothy Bishop, Tracy A. O'Mara, Kirsten B. Moysich, Corect, Laufey T. Amundadottir, Marjanka K. Schmidt, Ian Tomlinson, Ocac, Yan Zhang, Gloria M. Petersen, Ali Amin Al Olama, Puya Gharahkhani, Deborah J. Thompson, Paul Brennan, Douglas F. Easton, Celeste Leigh Pearce, InterLymph, Jacques Simard, Mark H. Greene, Zsofia Kote-Jarai, Nilanjan Chatterjee, Ecac, Marlene Danner Dalgaard, Mark P. Purdue, Beatrice Melin, Graham Casey, Rajesh Kumar, Jenny Chang-Claude, Thomas A. Sellers, Stephen B. Gruber, Beacon, James D. McKay, Tecac, Stephanie L. Schmit, Tom Grotmol, Kyriaki Michailidou, Immaculata De Vivo, Joellen M. Schildkraut, Eric J. Jacobs, Fredrik Wiklund, Amanda B. Spurdle, Nathaniel Rothman, Parichoy Pal Choudhury, Peter Kraft, Panc, Renal Cancer Gwas, Neil E. Caporaso, Joe Dennis, Matthew Law, Fredrick R. Schumacher, Harvey A. Risch, Stuart MacGregor, Andrew Berchuck, Ilcco, Oral Cancer Gwas

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Zhang, Y D, Hurson, A N, Zhang, H, Choudhury, P P, Easton, D F, Milne, R L, Simard, J, Hall, P, Michailidou, K, Dennis, J, Schmidt, M K, Chang-Claude, J, Gharahkhani, P, Whiteman, D, Campbell, P T, Hoffmeister, M, Jenkins, M, Peters, U, Hsu, L, Gruber, S B, Casey, G, Schmit, S L, O’Mara, T A, Spurdle, A B, Thompson, D J, Tomlinson, I, De Vivo, I, Landi, M T, Law, M H, Iles, M M, Demenais, F, Kumar, R, MacGregor, S, Bishop, D T, Ward, S V, Bondy, M L, Houlston, R, Wiencke, J K, Melin, B, Barnholtz-Sloan, J, Kinnersley, B, Wrensch, M R, Amos, C I, Hung, R J, Brennan, P, McKay, J, Caporaso, N E, Berndt, S I, Birmann, B M, Camp, N J, Kraft, P, Rothman, N, Slager, S L, Berchuck, A, Pharoah, P D P, Sellers, T A, Gayther, S A, Pearce, C L, Goode, E L, Schildkraut, J M, Moysich, K B, Amundadottir, L T, Jacobs, E J, Klein, A P, Petersen, G M, Risch, H A, Stolzenberg-Solomon, R Z, Wolpin, B M, Li, D, Eeles, R A, Haiman, C A, Kote-Jarai, Z, Schumacher, F R, Al Olama, A A, Purdue, M P, Scelo, G, Dalgaard, M D, Greene, M H, Grotmol, T, Kanetsky, P A, McGlynn, K A, Nathanson, K L, Turnbull, C, Wiklund, F, Bishop, D T, Chanock, S J, Chatterjee, N & Garcia-Closas, M 2020, ' Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers ', Nature Communications, vol. 11, no. 1, 3353 . https://doi.org/10.1038/s41467-020-16483-3
Nature Communications
Zhang, Y D, Hurson, A N, Zhang, H, Choudhury, P P, Easton, D F, Milne, R L, Simard, J, Hall, P, Michailidou, K, Dennis, J, Schmidt, M K, Chang-claude, J, Gharahkhani, P, Whiteman, D, Campbell, P T, Hoffmeister, M, Jenkins, M, Peters, U, Hsu, L, Gruber, S B, Casey, G, Schmit, S L, O’mara, T A, Spurdle, A B, Thompson, D J, Tomlinson, I, De Vivo, I, Landi, M T, Law, M H, Iles, M M, Demenais, F, Kumar, R, Macgregor, S, Bishop, D T, Ward, S V, Bondy, M L, Houlston, R, Wiencke, J K, Melin, B, Barnholtz-sloan, J, Kinnersley, B, Wrensch, M R, Amos, C I, Hung, R J, Brennan, P, Mckay, J, Caporaso, N E, Berndt, S I, Birmann, B M, Camp, N J, Kraft, P, Rothman, N, Slager, S L, Berchuck, A, Pharoah, P D P, Sellers, T A, Gayther, S A, Pearce, C L, Goode, E L, Schildkraut, J M, Moysich, K B, Amundadottir, L T, Jacobs, E J, Klein, A P, Petersen, G M, Risch, H A, Stolzenberg-solomon, R Z, Wolpin, B M, Li, D, Eeles, R A, Haiman, C A, Kote-jarai, Z, Schumacher, F R, Al Olama, A A, Purdue, M P, Scelo, G, Dalgaard, M D, Greene, M H, Grotmol, T, Kanetsky, P A, Mcglynn, K A, Nathanson, K L, Turnbull, C, Wiklund, F, Chanock, S J, Chatterjee, N & Garcia-closas, M 2020, ' Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers ', Nature Communications, vol. 11, no. 1 . https://doi.org/10.1038/s41467-020-16483-3

Genome-wide association studies (GWAS) have led to the identification of hundreds of susceptibility loci across cancers, but the impact of further studies remains uncertain. Here we analyse summary-level data from GWAS of European ancestry across fou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8e609c25614fbed083ff54499bd1fd
https://www.repository.cam.ac.uk/handle/1810/324794

UV and global irradiance measurements and analysis during the Marsaxlokk (Malta) campaign

Autor: Bilbao, Julia, Roman, Roberto, Yousif, Charles, Mateos, David, Miguel, Argimiro de, 14th EMS Annual Meeting & 10th European Conference on Applied Climatology (ECAC)

Publikováno v: Advances in Science and Research, Vol 12, Pp 147-155 (2015)

A solar radiation measurement campaign was performed in the south-eastern village of Marsaxlokk (35 500 N; 14 330 E; 10m a.s.l), Malta, between 15 May and 15 October 2012. Erythemal solar radiation data (from a UVB-1 pyranometer), and total horizonta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25f6e023b51d2c3620b84936ed1ded4
http://www.adv-sci-res.net/12/147/2015/asr-12-147-2015.pdf