Zobrazeno 1 - 2
of 2
pro vyhledávání: '"EC50, compound concentration affording 50% inhibition of the viral cytopathicity"'
Autor:
Graciela Andrei, Maxime Bessières, Vincent Roy, Vincent Hervin, Jean-François Lohier, Agnes Chartier, Robert Snoeck, Luigi A. Agrofoglio
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 146, pp.678-686. ⟨10.1016/j.ejmech.2018.01.086⟩
European Journal of Medicinal Chemistry, 2018, 146, pp.678-686. ⟨10.1016/j.ejmech.2018.01.086⟩
European Journal of Medicinal Chemistry, Elsevier, 2018, 146, pp.678-686. ⟨10.1016/j.ejmech.2018.01.086⟩
European Journal of Medicinal Chemistry, 2018, 146, pp.678-686. ⟨10.1016/j.ejmech.2018.01.086⟩
Several hitherto unknown (E)-but-2-enyl nucleoside phosphonoamidate analogs (ANPs) were prepared directed with nitrogen reagents by cross-metathesis in water-under ultrasound irradiation. Two diastereoisomers were formally identified by X-ray diffrac
Autor:
Tamara R. McBrayer, Manabu Hamada, Robert Snoeck, Tony Whitaker, Vincent Roy, Jan Balzarini, César A. Urbina-Blanco, Steven P. Nolan, Luigi A. Agrofoglio, Raymond F. Schinazi, Graciela Andrei
Publikováno v:
European Journal of Medicinal Chemistry
A series of seventeen hitherto unknown ANP analogs bearing the (E)-but-2-enyl aliphatic side chain and modified heterocyclic base such as cytosine and 5-fluorocytosine, 2-pyrazinecarboxamide, 1,2,4-triazole-3-carboxamide or 4-substituted-1,2,3-triazo