Zobrazeno 1 - 7
of 7
pro vyhledávání: '"E545K mutation"'
Autor:
Hiroyuki Yoda, Jason Lin, Takayoshi Watanabe, Nobuko Koshikawa, Atsushi Takatori, Takahiro Inoue, Hiroki Nagase, Sakthisri Krishnamurthy, Yoshinao Shinozaki, Kiriko Hiraoka
Publikováno v:
Cancer Science
PIK3CA is the most frequently mutated oncogene in cervical cancer, and somatic mutations in the PIK3CA gene result in increased activity of PI3K. In cervical cancer, the E545K mutation in PIK3CA leads to elevated cell proliferation and reduced apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa96551b546b48f72aabcd8659aebd9
http://europepmc.org/articles/PMC7935806
http://europepmc.org/articles/PMC7935806
Autor:
Krishnamurthy, Sakthisri, Yoda, Hiroyuki, Hiraoka, Kiriko, Inoue, Takahiro, Lin, Jason, Shinozaki, Yoshinao, Watanabe, Takayoshi, Koshikawa, Nobuko, Takatori, Atsushi, Nagase, Hiroki
Publikováno v:
Cancer science, vol 112, iss 3
PIK3CA is the most frequently mutated oncogene in cervical cancer, and somatic mutations in the PIK3CA gene result in increased activity of PI3K. In cervical cancer, the E545K mutation in PIK3CA leads to elevated cell proliferation and reduced apopto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______325::abb26f4f1d33c78ff6aef39c242c3c94
https://escholarship.org/uc/item/5kd9m2xw
https://escholarship.org/uc/item/5kd9m2xw
Publikováno v:
Chemical Science, Vol. 11, No 13 (2020) pp. 3511-3515
Chemical Science
Chemical Science
PI3Kα controls several cellular processes and its aberrant signalling is implicated in tumorigenesis. One of its hotspot mutations, E545K, increases PI3Kα lipid kinase activity, but its mode of action is only partially understood. Here, we perform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd8b9791f21f170bc05abbc0edbf0bb
https://archive-ouverte.unige.ch/unige:150632
https://archive-ouverte.unige.ch/unige:150632
Akademický článek
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Autor:
Χριστοφορίδης, Σάββας, Φριλίγγος, Ευστάθιος, Τζαβάρας, Θεόδωρος, Κωλέττας, Ευάγγελος, Κούκλης, Παναγιώτης
Το ένζυμο ΡΙ3 κινάση είναι ένα ετεροδιμερές μόριο που αποτελείται από μια ρυθμιστική (ρ85α) και μια καταλυτική (ρ110α) υπομονάδα. Η καταλυτι
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_____10561::39d38653da715b58e59fd3290fa61cd9
https://olympias.lib.uoi.gr/jspui/handle/123456789/27850
https://olympias.lib.uoi.gr/jspui/handle/123456789/27850
Autor:
Woo-Jeong Lee, Sharada Kolekar, Christina M. Buchanan, Peter R. Shepherd, Stephen M. F. Jamieson, Jack U. Flanagan, Jackie D. Kendall, William A. Denny, Ripudaman Singh, James M. J. Dickson, Bruce C. Baguley, Gordon W. Rewcastle
Publikováno v:
Biochemical Journal
Genetic alterations in PI3K (phosphoinositide 3-kinase) signalling are common in cancer and include deletions in PTEN (phosphatase and tensin homologue deleted on chromosome 10), amplifications of PIK3CA and mutations in two distinct regions of the P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1a7d1444366d807c36dc5923f61ac0
https://doi.org/10.1042/bj20110502
https://doi.org/10.1042/bj20110502
Akademický článek
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