Zobrazeno 1 - 10
of 6 601
pro vyhledávání: '"E3 ligase"'
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Autophagy is an important lysosomal degradation process that digests and recycles bio-molecules, protein or lipid aggregates, organelles, and invaded pathogens. Autophagy plays crucial roles in regulation of metabolic and oxidative stress an
Externí odkaz:
https://doaj.org/article/32181126f9584ec6ba1329b178411dca
Autor:
Kaixiang Zhu, Lili Song, Linyue Wang, Lei Hua, Ziyu Luo, Tongyun Wang, Bo Qin, Shuofeng Yuan, Xiaopan Gao, Wenyi Mi, Sheng Cui
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 9, Pp 4164-4173 (2024)
Viruses often manipulate ubiquitination pathways to facilitate their replication and pathogenesis. CUL2ZYG11B known as the substrate receptor of cullin-2 RING E3 ligase, is bound by SARS-CoV-2 ORF10 to increase its E3 ligase activity, leading to degr
Externí odkaz:
https://doaj.org/article/aff45cef243f48ada74712a089d7e713
Publikováno v:
Advanced Science, Vol 11, Iss 39, Pp n/a-n/a (2024)
Abstract Arboviruses, transmitted by medical arthropods, pose a serious health threat worldwide. During viral infection, Post Translational Modifications (PTMs) are present on both host and viral proteins, regulating multiple processes of the viral l
Externí odkaz:
https://doaj.org/article/485b7ae2e30242c9b5a0dda95643537d
Autor:
Dipti Ranjan Lenka, Shakti Virendra Dahe, Odetta Antico, Pritiranjan Sahoo, Alan R Prescott, Miratul MK Muqit, Atul Kumar
Publikováno v:
eLife, Vol 13 (2024)
Loss-of-function Parkin mutations lead to early-onset of Parkinson’s disease. Parkin is an auto-inhibited ubiquitin E3 ligase activated by dual phosphorylation of its ubiquitin-like (Ubl) domain and ubiquitin by the PINK1 kinase. Herein, we demonst
Externí odkaz:
https://doaj.org/article/3f29e2a6e59d486a8abd2e720c70fea9
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 101150- (2024)
The advent of tyrosine kinase inhibitors (TKI) targeting BCR-ABL has drastically changed the treatment approach of chronic myeloid leukemia (CML), greatly prolonged the life of CML patients, and improved their prognosis. However, TKI resistance is st
Externí odkaz:
https://doaj.org/article/7cfec49cead04316911cebf15dc34f7c
Akademický článek
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Autor:
Azfar Jamal
Publikováno v:
Journal of Pharmacy and Bioallied Sciences, Vol 16, Iss Suppl 3, Pp S1984-S1986 (2024)
E3 ubiquitin ligases are a class of enzymes, essential for maintaining the equilibrium of cells by binding ubiquitin molecules to substrates to mark them for destruction. Since many cancer-related proteins, including both oncogenic and tumor-suppress
Externí odkaz:
https://doaj.org/article/2d07181caa8e4be0983b556fc57ebe7e
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e34032- (2024)
Thyroid cancer is the most common malignant tumor of the endocrine system, and evidence suggests that post-translational modifications (PTMs) and epigenetic alterations play an important role in its development. Recently, there has been increasing ev
Externí odkaz:
https://doaj.org/article/babb912b37b54bfcbae30be8eb1c18f0
Publikováno v:
Biochemistry and Biophysics Reports, Vol 38, Iss , Pp 101740- (2024)
Lung cancer is a leading cause of cancer-related death, and the most common type of lung cancer is non-small cell lung cancer, which accounts for approximately 85 % of lung cancer diagnoses. Recent studies have revealed that ubiquitination acts as a
Externí odkaz:
https://doaj.org/article/a03ad0f0a8d44aceab7e2d892ac64d16
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
IntroductionThe Anaphase Promoting Complex (APC/C), an E3 ubiquitin ligase, plays a key role in cell cycle control, but it is also thought to operate in postmitotic neurons. Most studies linking APC/C function to neuron biology employed perturbations
Externí odkaz:
https://doaj.org/article/73399164e6ca4ec1ab7b766a61f467d4