Zobrazeno 1 - 10
of 51
pro vyhledávání: '"E2F Transcription Factor Family"'
Autor:
Pengqian Zhang, Xingcong Ma, Ting Zhang, Yue Li, Ling Ma, Meng Qu, Xiaoyan Zhou, Wei Dong, Qian He
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Background:BRCA1/2 mutations are closely related to high lifetime risk of breast cancer (BC). The objective of this study was to identify the genes, regulators, and immune-associated patterns underlying disease pathology in BC with BRCA1/2 somatic mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677c4ec6b57b9c0c62d78c298633c2de
https://doi.org/10.3389/fcell.2021.750897
https://doi.org/10.3389/fcell.2021.750897
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology
Frontiers in Oncology
Gastric cancer is the most common malignant tumor in the digestive tract, with very high morbidity and mortality in developing countries. The pathogenesis of gastric cancer is a complex biological process mediated by abnormal regulation of proto-onco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0466dc8d6013ca9c692f8ac18e23a3a2
https://doi.org/10.3389/fonc.2021.655630
https://doi.org/10.3389/fonc.2021.655630
Publikováno v:
Cancers, Vol 13, Iss 934, p 934 (2021)
Cancers
Cancers
Simple Summary Retinoblastoma (RB) proteins and E2F transcription factors partner together to regulate the cell cycle in many eukaryotic organisms. In organisms that lack one or both of these proteins, other proteins have taken on the essential funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c435e8e39d9f4301ba71056113b33f90
https://www.mdpi.com/2072-6694/13/5/934
https://www.mdpi.com/2072-6694/13/5/934
Publikováno v:
Current molecular medicine. 21(8)
Selected transcription factors have critical roles to play in organism survival by regulating the expression of genes that control the adaptations needed to handle stress conditions. The retinoblastoma (Rb) protein coupled with the E2F transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271e89e13486ccb1ad0f85d9bec55557
https://pubmed.ncbi.nlm.nih.gov/33397238
https://pubmed.ncbi.nlm.nih.gov/33397238
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
The mammalian inner ear has a limited capacity to regenerate its mechanosensory hair cells. This lack of regenerative capacity underlies the high incidence of age-related hearing loss in humans. In contrast, non-mammalian vertebrates can form new hai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd84712052a00c59f2b9678240ea788b
https://pubmed.ncbi.nlm.nih.gov/34588543
https://pubmed.ncbi.nlm.nih.gov/34588543
Autor:
Zhengshuo Li, Can Liu, Xiaoyue Zhang, Qun Yan, Yangge Wu, Jian Ma, Peishan Liu, Lingyu Wei, Qiu Peng
Publikováno v:
Biochemical and biophysical research communications. 524(4)
Nasopharyngeal carcinoma (NPC) is a malignant tumor from head and neck with characteristics in remarkable geographic and racial distribution worldwide, which has the important features of vigorous proliferation and inflammatory cells infiltration. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8a0eaf2bf7e271a54d75cd26260d6d
https://pubmed.ncbi.nlm.nih.gov/32044038
https://pubmed.ncbi.nlm.nih.gov/32044038
Autor:
Paolo Macchi, Toma Tebaldi, Richard A. Padgett, Nicola Cornella, Jarnail Singh, Lisa Gasperini, Annalisa Rossi
Publikováno v:
Journal of Biological Chemistry. 292:19674-19692
The heterogeneous nuclear ribonucleoproteins (hnRNP) form a large family of RNA-binding proteins that exert numerous functions in RNA metabolism. RALY is a member of the hnRNP family that binds poly-U–rich elements within several RNAs and regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6569b52a9277407468cb8fc88e6ee0bb
https://doi.org/10.1074/jbc.m117.795591
https://doi.org/10.1074/jbc.m117.795591
Autor:
Gerd A. Müller, Martin Fischer
Publikováno v:
Critical Reviews in Biochemistry and Molecular Biology. 52:638-662
The precise timing of cell cycle gene expression is critical for the control of cell proliferation; de-regulation of this timing promotes the formation of cancer and leads to defects during differentiation and development. Entry into and progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb3d3865a7e1ffe4e6e3450e5f591ec
https://doi.org/10.1080/10409238.2017.1360836
https://doi.org/10.1080/10409238.2017.1360836
Autor:
Satyaki Sengupta, Edgar M. Medina, Nicolas E. Buchler, Tyler J. Liban, Sarvind Tripathi, R. William Henry, Seth M. Rubin
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 114, iss 19
The retinoblastoma protein (Rb) and the homologous pocket proteins p107 and p130 negatively regulate cell proliferation by binding and inhibiting members of the E2F transcription factor family. The structural features that distinguish Rb from other p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afbd7ac69c862c72de57cd079fe5e26
https://doi.org/10.1073/pnas.1619170114
https://doi.org/10.1073/pnas.1619170114
Autor:
Sumadi Lukman Anwar, Ulrich Lehmann
Publikováno v:
Methods in Molecular Biology ISBN: 9781493975648
The retinoblastoma protein (pRb) plays a central role in the regulation of cell cycle by interaction with members of the E2F transcription factor family. As a tumor suppressor protein, pRb is frequently dysregulated in several major cancers. In addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4114749ddb8356be97b3ca6136f28a9f
https://doi.org/10.1007/978-1-4939-7565-5_5
https://doi.org/10.1007/978-1-4939-7565-5_5
