Zobrazeno 1 - 10
of 62
pro vyhledávání: '"E1B55k"'
Publikováno v:
Molecular Therapy: Oncolytics, Vol 27, Iss , Pp 26-47 (2022)
Systemic delivery of oncolytic viruses has been widely regarded as an impractical option for antitumor treatment. Here, we selected two target genes as leading components, and significant therapeutic effects were obtained by simultaneously reducing t
Externí odkaz:
https://doaj.org/article/2161cc64333c47d29a1c95f031682dc9
Autor:
Tareq Abualfaraj, Nafiseh Chalabi Hagkarim, Robert Hollingworth, Laura Grange, Satpal Jhujh, Grant S. Stewart, Roger J. Grand
Publikováno v:
Viruses, Vol 13, Iss 12, p 2444 (2021)
The adenovirus 12 early region 1B55K (Ad12E1B55K) protein has long been known to cause non-random damage to chromosomes 1 and 17 in human cells. These sites, referred to as Ad12 modification sites, have marked similarities to classic fragile sites. I
Externí odkaz:
https://doaj.org/article/b5e37f1dd3b2439ab39b2c81ab6bf2a7
Autor:
Frédéric Dallaire, Sabrina Schreiner, G. Eric Blair, Thomas Dobner, Philip E. Branton, Paola Blanchette
Publikováno v:
mSphere, Vol 1, Iss 1 (2016)
ABSTRACT Human adenovirus (Ad) E1A proteins have long been known as the central regulators of virus infection as well as the major source of adenovirus oncogenic potential. Not only do they activate expression of other early viral genes, they make vi
Externí odkaz:
https://doaj.org/article/3384865bcf664ed09b505b5af535d394
Autor:
Frédéric Dallaire, Sabrina Schreiner, G. Eric Blair, Thomas Dobner, Philip E. Branton, Paola Blanchette
Publikováno v:
mSphere, Vol 1, Iss 1 (2016)
ABSTRACT The human adenovirus E4orf6/E1B55K E3 ubiquitin ligase is well known to promote viral replication by degrading an increasing number of cellular proteins that inhibit the efficient production of viral progeny. We report here a new function of
Externí odkaz:
https://doaj.org/article/c01a38eed5be44cc8477ec767683e17f
Akademický článek
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Autor:
Mohammad Arif Rahman, Leia K. Miller-Novak, David C. Montefiori, Celia C. LaBranche, David Venzon, Marjorie Robert-Guroff, Diego A. Vargas-Inchaustegui, Kotou Sangare, Iskra Tuero, Tanya Hoang, Michael A. Thomas
Publikováno v:
Journal of Virology
Adenovirus (Ad) is being explored for use in the prevention and treatment of a variety of infectious diseases and cancers. Here, we provide evidence in cells, mice, and nonhuman primates supporting the notion that Ad early gene products limit specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47591414f94b6838e5ad96881140547e
https://doi.org/10.1128/jvi.02253-20
https://doi.org/10.1128/jvi.02253-20
Autor:
Tetsuya Kitamura, Ishraque Ahmed, Elora Hossain, Motoaki Yasuda, Yohei Mikawa, Aya Yanagawa-Matsuda, Umma Habiba, Fumihiro Higashino, Mohammad Towfik Alam, Masanobu Shindoh, Yoshimasa Kitagawa
Publikováno v:
Cancers
Volume 12
Issue 5
Cancers, Vol 12, Iss 1205, p 1205 (2020)
Volume 12
Issue 5
Cancers, Vol 12, Iss 1205, p 1205 (2020)
AU-rich elements (AREs) are RNA elements that enhance the rapid decay of mRNAs, including those of genes required for cell growth and proliferation. HuR, a member of the embryonic lethal abnormal vision (ELAV) family of RNA-binding proteins, is invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4239aea1f1a2fb231829cf59ecf3f18
Akademický článek
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Akademický článek
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Autor:
Wolfgang Wurst, Timm Weber, Klaus Rajewsky, Sandrine Sander, Ralf Kühn, Van Trung Chu, Benedikt Wefers
Publikováno v:
Nature biotechnology 33(5), 543-548 (2015). doi:10.1038/nbt.3198
The insertion of precise genetic modifications by genome editing tools such as CRISPR-Cas9 is limited by the relatively low efficiency of homology-directed repair (HDR) compared with the higher efficiency of the nonhomologous end-joining (NHEJ) pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f315a2226037da438b9f90f6348ed14f
https://doi.org/10.1038/nbt.3198
https://doi.org/10.1038/nbt.3198