Zobrazeno 1 - 10
of 36
pro vyhledávání: '"E.W. Karbon"'
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2035-2040
The synthesis of ten 4-phosphonoalkylquinoline derivatives and the evaluation of their glutamate antagonist activity is described. Several compounds demonstrate significant antagonism at both 6-cyano-7-nitroquinoxalin-2,3-dione (CNQX) binding sites a
Autor:
E.W. Karbon, Gregory S. Hamilton, Z. Huang, J.W. Ferkany, S.A. Borosky, R. Zubrowski, D.L. Bednar
Publikováno v:
ChemInform. 26
Autor:
Raymond J. Patch, E.W. Karbon, D.L. Bednar, R.L. Elliott, Z. Huang, M.E. Guzewska, G.S. Hamilton, J.W. Ferkany, S.A. Borosky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 2:1269-1274
Substituted phosphonoethylphenylalanines were evaluated for their ability to antagonize kainic acid (KA)- and AMPA-induced currents in Xenopus oocytes. Compounds which were substituted in the 5-position of the aromatic ring were found to selectively
Publikováno v:
Behavioural pharmacology. 3(4)
The strychnine insensitive glycine receptor antagonists (+/-) HA 966 (2.5, 3.5, 4.25 and 5.0mg/kg) and 7 chlorokynurenic acid (5.0, 10.0, and 15.0mg/kg), the putative sigma agents NPC 16377 (5.0 and 8.0mg/kg), BMY 14802 (5.0, 7.5 and 10.0mg/kg), and
Publikováno v:
European journal of pharmacology. 193(1)
The interaction of various compounds with sigma binding sites was examined in membranes prepared from whole guinea pig brain. Whereas [3H](+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine labeled a single population of binding sites exhibiting a Kd of 4
Autor:
E.W. Karbon, S.J. Enna
Publikováno v:
Trends in Pharmacological Sciences. 8:21-24
Neurotransmitter receptor responsiveness is regulated by a variety of factors. One of these appears to be through an association between the neurotransmitter receptor-coupled effector system and receptors for other substances that serve to modify, ra
Publikováno v:
Brain Research. 330:135-140
Experiments were undertaken to determine the site of action of securinine and related convulsant indolizidines. All of these compounds induced tonic seizures in mice, with CD50 values ranging from 11 to 87 mg/kg. The CD50 for bicuculline was found to
Publikováno v:
Journal of neurochemistry. 47(3)
Experiments were undertaken to define the role of two calcium-associated enzyme systems in modulating transmitter-stimulated production of cyclic nucleotides in rat brain. Cyclic AMP (cAMP) accumulation was examined in cerebral cortical slices using
Publikováno v:
Brain research. 306(1-2)
The ability of GABAergic compounds to influence cAMP accumulation in rat brain cortex was examined. It was found that GABAB receptor agonists such as GABA, baclofen, and kojic amine potentiate the cAMP response in cerebral cortex during exposure to n
Autor:
Salvatore J. Enna, E.W. Karbon
Publikováno v:
Neuropharmacology. 23:821-822
Baclofen and other GABA B receptor agonists have little or no effect on cAMP production in rat brain slices. However, these agents potentiate the cAMP response occuring during exposure to norepinephrine, isoproterenol, histamine and adenosine. This i