Integrating genome-wide polygenic risk scores and non-genetic risk to predict colorectal cancer diagnosis: a cohort study in UK Biobank

Autor: E.W Briggs, Sarah, Law, Philip, E. East, James, Wordsworth, Sarah, Dunlop, Malcolm G, Houlston, Richard, Hippisley-Cox, Julia, Tomlinson, Ian P.M.

Publikováno v: E.W Briggs, S, Law, P, E. East, J, Wordsworth, S, Dunlop, M G, Houlston, R, Hippisley-Cox, J & Tomlinson, I P M 2022, ' Integrating genome-wide polygenic risk scores and non-genetic risk to predict colorectal cancer diagnosis: a cohort study in UK Biobank ', British Medical Journal (BMJ) . https://doi.org/10.1136/bmj-2022-071707

Objective To evaluate the benefit of combining polygenic risk scores with the QCancer-10 (colorectal cancer) prediction model for non-genetic risk to identify people at highest risk of colorectal cancer.Design Population based cohort study.Setting Da

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3094::f0f9ca7b00833fbd90dec1588460d440
https://www.pure.ed.ac.uk/ws/files/308996345/bmj_2022_071707.full.pdf