Characterization of metalloprotease cleavage products of human articular cartilage

Autor: D. A. Laska, Kevin L. Duffin, Eugene Y. Zhen, P.G. Mitchell, E.U. Sumer, Morten A. Karsdal, I.J. Brittain

Publikováno v: Arthritis & Rheumatism. 58:2420-2431

Objective To identify, characterize, and compare proteolysis peptide products generated by metalloprotease digests of human articular cartilage. Methods Human articular cartilage was digested by the addition of exogenous metalloproteases, including m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3d0a3a98b8309e4a0abc8604e819ddb
https://doi.org/10.1002/art.23654

Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase–mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation

Autor: Suzi H Madsen, Claus Christiansen, Bodil-Cecilie Sondergaard, Amanda J. Fosang, Morten A. Karsdal, E.U. Sumer, Helle Wulf

Publikováno v: Karsdal, M A, Sumer, E U, Wulf, H, Madsen, S H, Christiansen, C, Fosang, A J & Sondergaard, B-C 2007, ' Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation ', Arthritis & Rheumatism, vol. 56, no. 5, pp. 1549-58 . https://doi.org/10.1002/art.22599

Udgivelsesdato: 2007-May OBJECTIVE: Calcitonin has been suggested to have chondroprotective effects. One signaling pathway of calcitonin is via the second messenger cAMP. We undertook this study to investigate whether increased cAMP levels in chondro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47106dd7ee98a3dd7a231ec897856189
https://doi.org/10.1002/art.22599

Application of biomarkers in the clinical development of new drugs for chondroprotection in destructive joint diseases: a review

Autor: Bodil-Cecilie Sondergaard, E.U. Sumer, László B. Tankó, Sophie Schaller, Per Qvist

Publikováno v: Biomarkers. 11:485-506

Emerging evidence supports the concept that biochemical markers are clinically useful non-invasive diagnostic tools for the monitoring of changes in cartilage turnover in patients with destructive joint diseases such as osteoarthritis (OA) and rheuma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7681769fadedc6f3f44e74b4196d58c
https://doi.org/10.1080/13547500600886115

Patients with rheumatoid arthritis have an altered circulatory aggrecan profile

Autor: Bodil-Cecilie Sondergaard, Per Qvist, Morten A. Karsdal, Thomas Neumann, E.U. Sumer, Jean C Rousseau, Pierre D. Delmas, Suzi H Madsen, Gert Hein, Andreas Dr Med Mueller, Christian Pedersen

Publikováno v: BMC Musculoskeletal Disorders
BMC Musculoskeletal Disorders, BioMed Central, 2008, 9, pp.74. ⟨10.1186/1471-2474-9-74⟩
BMC Musculoskeletal Disorders, Vol 9, Iss 1, p 74 (2008)

Background Rheumatoid arthritis (RA) is a chronic auto-immune disease with extensive articular cartilage destruction. Aggrecan depletion, mediated by aggrecanases is one of the first signs of early cartilage erosion. We investigated, whether measurem

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https://www.hal.inserm.fr/inserm-02072542

P85 INTERLEUKIN-1 ALPHA IN COMPARISON TO INTERLEUKIN-1 BETA IS A MORE POTENT STIMULATOR OF AGGRECANASE MEDIATED AGGRECAN DEGRADATION IN HUMAN ARTICULAR CARTILAGE

Autor: M.A. Qvist, B.C. Sondergaard, S.H. Madsen, E.U. Sumer, Per Qvist

Publikováno v: Osteoarthritis and Cartilage. 14

Purpose: Aggrecan is the predominant proteoglycan in the extracellular matrix of articular cartilage. One of the early steps in initiation of cartilage degradation is loss of proteoglycans, which leads to further degradation of the collagen network.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29fcf554987a4b5566549a2c470f3e05