Zobrazeno 1 - 10 of 57 pro vyhledávání: '"E.S. Phillips"'
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Folic Acid Supplementation during the Juvenile-Pubertal Period in Rats Modifies the Phenotype and Epigenotype Induced by Prenatal Nutrition
Autor: Graham C. Burdge, Mark A. Hanson, Alan Jackson, Karen A. Lillycrop, Joanne L. Slater-Jefferies, E.S. Phillips
Publikováno v: The Journal of Nutrition. 139:1054-1060
Prenatal nutritional constraint is associated with increased risk of metabolic dysregulation in adulthood contingent on adult diet. In rats, folic acid supplementation of a protein-restricted (PR) diet during pregnancy prevents altered phenotype and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c3770ee53a442fdc661330f3d694587
https://doi.org/10.3945/jn.109.104653
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Metabolic plasticity during mammalian development is directionally dependent on early nutritional status
Autor: E.S. Phillips, Mark H. Vickers, Alan S. Beedle, Peter D. Gluckman, Karen A. Lillycrop, A. B. Pleasants, Mark A. Hanson, Graham C. Burdge
Publikováno v: Proceedings of the National Academy of Sciences. 104:12796-12800
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for most mammalian traits. The metabolic phenotype of ad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05673cea3f6e2ce36740262ec61b013
https://doi.org/10.1073/pnas.0705667104
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Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations
Autor: Graham C. Burdge, Christopher Torrens, Mark A. Hanson, Karen A. Lillycrop, Jo Slater-Jefferies, E.S. Phillips
Publikováno v: British Journal of Nutrition. 97:435-439
Epidemiological studies and experimental models show that maternal nutritional constraint during pregnancy alters the metabolic phenotype of the offspring and that this can be passed to subsequent generations. In the rat, induction of an altered meta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4802a74b63cba119cbbb1de11d071214
https://doi.org/10.1017/s0007114507352392
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Dietary Protein Restriction of Pregnant Rats Induces and Folic Acid Supplementation Prevents Epigenetic Modification of Hepatic Gene Expression in the Offspring
Autor: Alan Jackson, Graham C. Burdge, E.S. Phillips, Mark A. Hanson, Karen A. Lillycrop
Publikováno v: The Journal of Nutrition. 135:1382-1386
Environmental constraints during early life result in phenotypic changes that can be associated with increased disease risk in later life. This suggests persistent alteration of gene transcription. DNA methylation, which is largely established in ute
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895a947098ef17e9336e7a4da07297fd
https://doi.org/10.1093/jn/135.6.1382
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Effect of reduced maternal protein consumption during pregnancy in the rat on plasma lipid concentrations and expression of peroxisomal proliferator–activated receptors in the liver and adipose tissue of the offspring
Autor: E.S. Phillips, Rebecca L. Dunn, Karen A. Lillycrop, Graham C. Burdge, Alan Jackson
Publikováno v: Nutrition Research. 24:639-646
The effect of protein consumption during pregnancy on peroxisomal proliferator-activated receptor (PPAR) expression and plasma lipid concentrations in the offspring were determined in the rat. Rats were fed isocaloric diets containing either 18% (w/w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77000bc90a34c7fba2ae79b823806fc8
https://doi.org/10.1016/j.nutres.2003.12.009
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Characterization of the Murine Nramp1 Promoter
Autor: C. Howard Barton, Irene Yeung, Abigail Lapham, Michal Alter-Koltunoff, Ben-Zion Levi, Holly Bowen, Derek A. Mann, V. Hugh Perry, E.S. Phillips
Publikováno v: Journal of Biological Chemistry. 278:36017-36026
Murine Nramp1 encodes a divalent cation transporter that is expressed in late endosomes/lysosomes of macrophages, and the transported cations facilitate intracellular pathogen growth control. The Nramp1 promoter is TATA box-deficient, has two initiat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70d4060100dac0a5525f6b6292bde6d5
https://doi.org/10.1074/jbc.m304301200
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c-Myc represses the murine Nrampl promoter
Autor: Thelma Biggs, C. H. Barton, Holly Bowen, V. H. Perry, Derek A. Mann, S. T. Baker, E.S. Phillips
Publikováno v: Biochemical Society Transactions. 30:774-777
The Nrampl (natural resistance-associated macrophage protein 1) gene modulates the growth of intracellular pathogens and encodes a divalent cation transporter within lysosomes/late endosomes of macrophages. Nrampl modulates the cytoplasmic iron pool.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c00672a1f4e572d61989810f8a1b46a
https://doi.org/10.1042/bst0300774
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Transcriptional control of Nramp1: a paradigm for the repressive action of c-Myc
Autor: E.S. Phillips, C. H. Barton, Abigail Lapham
Publikováno v: Biochemical Society Transactions. 32:1084-1086
Slc11a1/Nramp1 (solute carrier family 11 member a1/murine natural resistance-associated macrophage protein 1 gene) encodes a divalent cation transporter that resides within lysosomes/late endosomes of macrophages. Nramp1 modulates the cellular distri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17d1b4a17d76cb7af61084f6b6b25dd
https://doi.org/10.1042/bst0321084
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