Zobrazeno 1 - 10
of 23
pro vyhledávání: '"E.K. Mberu"'
Autor:
William M. Watkins, Charles R. Newton, Peter Warn, David A. Warrell, Peter Winstanley, I Mwangi, C Waruiru, Kevin Marsh, C. Nevill, E.K. Mberu
Publikováno v:
Scopus-Elsevier
1. H.p.l.c. methods are described for the measurement of pyrimethamine and sulphadoxine in small volumes of plasma dried on filter paper strips. 2. Pyrimethamine/sulphadoxine (Fansidar, Hoffman LaRoche) was given by mouth and by intramuscular injecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9cffd7f08b901adfc4d9b01595ed4b
https://doi.org/10.1111/j.1365-2125.1992.tb04016.x
https://doi.org/10.1111/j.1365-2125.1992.tb04016.x
Autor:
C Waruiru, Charles R. Newton, William M. Watkins, Stephen A. Ward, David A. Warrell, G Pasvol, Peter Warn, E.K. Mberu, I Mwangi, Peter Winstanley
Young African children with severe malaria are given quinine using a regimen designed for Thai adults. We measured quinine in the blood, plasma and plasma water of young children in Kenya after rapid intravenous and intramuscular dosing, and calculat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42da4e6b3eb87de73975fa8f08b9641
https://ora.ox.ac.uk/objects/uuid:99b9f42e-f766-445a-85ca-f9b169fa941a
https://ora.ox.ac.uk/objects/uuid:99b9f42e-f766-445a-85ca-f9b169fa941a
Autor:
Malcolm E. Molyneux, Terrie E. Taylor, Peter Winstanley, Benedetto Falsini, E.K. Mberu, Jonathan Lochhead, Simon P. Harding, Charles E. Riva, Armand Movaffaghy
Publikováno v:
The Journal of Infectious Diseases. 187:1342-1345
To investigate the effects of quinine on the electroretinograms (ERGs) of children with cerebral malaria (CM), we recruited subjects during a single malaria season in Blantyre, Malawi. Seventy ERG investigations were performed, on 34 children with CM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b92b81a8356d9f68d6f0569c752ae079
https://doi.org/10.1086/374058
https://doi.org/10.1086/374058
Autor:
Alexis Nzila, Carol Hopkins Sibley, Amanda Ross, E.K. Mberu, Eunice Nduati, William M. Watkins
Publikováno v:
International Journal for Parasitology. 32:1469-1476
The genotypes of merozoite surface protein-1, merozoite surface protein-2 and glutamine rich protein are frequently used to distinguish recrudescence from reinfection when parasitaemia reappears after antimalarial drug treatment. However, none of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835111e771ad5f592091c432afc22df4
https://doi.org/10.1016/s0020-7519(02)00164-9
https://doi.org/10.1016/s0020-7519(02)00164-9
Autor:
William M. Watkins, Carol Hopkins Sibley, Gilbert Kokwaro, Amanda Ross, Stephanie M. Monks, E.K. Mberu, Eunice Nduati, Alexis Nzila
Publikováno v:
Experimental Parasitology. 101:90-96
We have determined the relationship between point mutations in the gene that encodes the sulfa target, dihydropteroate synthase (DHPS) and the chemosensitivity profile to sulfadoxine and dapsone in 67 isolates from Kilifi, Kenya. We assessed the pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b727139ae790af9b0c854c85d639e794
https://doi.org/10.1016/s0014-4894(02)00108-x
https://doi.org/10.1016/s0014-4894(02)00108-x
Autor:
Elizabeth Hills, Theonest K. Mutabingwa, E.K. Mberu, Peter Winstanley, William M. Watkins, Eunice Nduati, Alexis Nzila
Publikováno v:
The Lancet. 358:1218-1223
Summary Background Resistance to the affordable malaria treatments chloroquine and pyrimethamine-sulfadoxine is seriously impeding malaria control through treatment in east Africa. We did an open, alternate drug allocation study to assess the efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be1b0ee9c0ab8f0cc46427b16cb07050
https://doi.org/10.1016/s0140-6736(01)06344-9
https://doi.org/10.1016/s0140-6736(01)06344-9
Autor:
William M. Watkins, E.K. Mberu, Carol Hopkins Sibley, Alexis Nzila, Peter Winstanley, Stephanie A. Monks, Eunice Nduati
Publikováno v:
The Journal of Infectious Diseases. 181:2023-2028
Pyrimethamine (PM) plus sulfadoxine (SD) is the last remaining affordable drug for treating uncomplicated malaria in Africa. The selective pressure exerted by the slowly eliminated combination PM/SD was compared with that exerted by the more rapidly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1105da9514f0228f1f40731505ad05f3
https://doi.org/10.1086/315520
https://doi.org/10.1086/315520
Publikováno v:
Biochemical Pharmacology. 48:889-895
The ability of the products of erythrocytic haemolysis and ferriprotoporphyrin (FP-IX)-containing substances to facilitate the decomposition of the antimalarial drug artemether has been evaluated in vitro . The products of haemolysis accelerate the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5ad0ffe2284c9bfd58af56ec501ab4
https://doi.org/10.1016/0006-2952(94)90359-x
https://doi.org/10.1016/0006-2952(94)90359-x
Autor:
Charles R. Newton, Peter Warn, C Waruiru, Kevin Marsh, Peter Winstanley, William M. Watkins, C.G. Nevill, I Mwangi, E.K. Mberu
Publikováno v:
Transactions of the Royal Society of Tropical Medicine and Hygiene. 87:207-210
It has been suggested that sulfadoxine-pyrimethamine ( SD PM ) may be useful in the treatment of severe malaria since it could enhance the killing of parasites by quinine (QN) and it can be given as a single intramuscular injection. Eighty Kenyan chi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add254c411440fc39d3db7095eaf50b4
https://doi.org/10.1016/0035-9203(93)90495-c
https://doi.org/10.1016/0035-9203(93)90495-c
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 570:180-184
An adaptation of an existing high-performance liquid chromatographic assay is described for the measurement of quinine, within the therapeutic concentration range, in whole blood. This method, in particular the use of small blood samples which have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b1e4a3f9f906cb9b47c1f12b5ca5362
https://doi.org/10.1016/0378-4347(91)80213-v
https://doi.org/10.1016/0378-4347(91)80213-v