Zobrazeno 1 - 10
of 24
pro vyhledávání: '"E.J. Westmijze"'
Publikováno v:
International Journal of Radiation Biology. 70:459-465
Oxygenated suspensions of M13 bacteriophages, containing single-stranded M13mp10 DNA, were gamma-irradiated followed by infection of E. coli cells. Mutants in the mutational target sequence, which consists of the lac promoter /operator region, the la
Publikováno v:
Free Radical Research. 21:9-17
Glutathione (GSH) was examined with respect to its ability to protect DNA against 1O2 damage. We have found that GSH protected, at least partly, the DNA against inactivation by 1O2. Up to 10 mM the protection increased as a function of GSH concentrat
Autor:
T.M.C.M. de Kok, J.C.S. Kleinjans, D. M. F. A. Pachen, M.V.M. Lafleur, E.J. Westmijze, J.M.S. van Maanen, F. ten Hoor
Publikováno v:
Carcinogenesis. 15:2559-2566
Fecapentaene-12 (FP-12), a fecal unsaturated, ether-linked lipid excreted by most human individuals in Western populations, has been found to be a potent genotoxin in mammalian cells. Its mechanism of genotoxicity may be mediated by oxygen radical-in
Publikováno v:
Chemico-Biological Interactions. 82:55-71
Incubation of RSU 1069 in the presence of biologically active double-stranded ΦX174 DNA resulted in, depending on pH, ionic strength and concentration of drug, inactivation of the DNA. A variety of lesions are induced including a high number of sing
Publikováno v:
Biochemical Pharmacology. 41:1649-1655
We have examined the capacity of the nitroimidazole aziridine antitumour drug RSU 1069 to react with DNA in vitro in order to get a better understanding of its mechanism of action. Moreover, we have utilized biologically active ΦX174 DNA to investig
Autor:
F.J. ten Vaarwerk, F. ten Hoor, J.M.S. van Maanen, J.C.S. Kleinjans, E.J. Westmijze, P.A.E.L. Schilderman, M.V.M. Lafleur
Publikováno v:
Carcinogenesis. 14(7)
The carcinogenicity of the phenolic food antioxidant butylated hydroxyanisole may be related to its oxidative biotransformation in vivo. In order to determine the ability of BHA, 2-tert-butyl(1,4)hydroquinone (TBHQ) and 2-tert-butyl(1,4)paraquinone (
Autor:
J. Retèl, D.R.A. Mans, Ivo R. Horn, D. Bets, Jan Lankelma, E.J. Westmijze, M.V.M. Lafleur, G.J. Schuurhuis
Publikováno v:
Biochemical pharmacology. 43(8)
Etoposide [4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta- D-glucopyranoside)] can be metabolized to DNA-inactivating catechol, ortho-quinone and semi-quinone free radical derivatives which may contribute to its cytotoxicity. In this paper, w
Autor:
M. A. Van Schaik, M.V.M. Lafleur, Jan Lankelma, D.R.A. Mans, J.M.S. van Maanen, J. Retel, E.J. Westmijze
Publikováno v:
Biochemical pharmacology. 42(11)
In this report, the types of DNA damage introduced by the ortho-quinone and the semiquinone free radical of 4'-demethylepipodophyllotoxin-9-(4-6-O-ethylidene-beta-D- glucopyranoside) (etoposide) and their relevance for the inactivation of single-stra
Publikováno v:
Mutation Research/Environmental Mutagenesis and Related Subjects. 360:207-208
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