IL-1β inhibition combined with cholesterol-lowering therapies decreases synovial lining thickness and spontaneous cartilage degeneration in a humanized dyslipidemia mouse model

Autor: Y. van Gemert, N.N.L. Kruisbergen, A.B. Blom, M.H.J. van den Bosch, P.M. van der Kraan, E.J. Pieterman, H.M.G. Princen, P.L.E.M. van Lent

Publikováno v: Osteoarthritis and Cartilage, 31, 340-350
Osteoarthritis and Cartilage, 31, 3, pp. 340-350

Contains fulltext : 290624.pdf (Publisher’s version ) (Open Access) INTRODUCTION: Both systemic inflammation and dyslipidemia contribute to osteoarthritis (OA) development and have been suggested as a possible link between metabolic disease and OA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ebc0184d586f46487a1cdf6132ed30
https://doi.org/10.1016/j.joca.2022.09.014

Atorvastatin attenuates diet-induced non-alcoholic steatohepatitis in ApoE*3-Leiden mice by reducing hepatic inflammation

Autor: J.A. Inia, A.M. Van Den Hoek, G. Stokman, E.J. Pieterman, M.C. Morrison, W.J. Jukema, H.M.G. Princen

Publikováno v: Atherosclerosis. 355:21

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::326336d53fe06754ee95a258e67c140e
https://doi.org/10.1016/j.atherosclerosis.2022.06.145

FRI0528 HIGH INTENSIVE THERAPEUTIC LOWERING OF SYSTEMIC CHOLESTEROL DOES NOT AMELIORATE OA DEVELOPMENT IN KNEE JOINTS OF HUMANIZED DYSLIPIDEMIC MICE

Autor: A.E. Kozijn, Reinout Stoop, Yvonne van Gemert, N. Kruisbergen, Peter L E M van Lent, Harrie Weinans, Martijn H J van den Bosch, E.J. Pieterman, Arjen B. Blom, Marianne G. Pouwer, Hans M.G. Princen

Publikováno v: Cartilage, synovium and bone.

Background High systemic cholesterol levels have been associated with osteoarthritis (OA) development and lowering cholesterol using statins has been suggested as a potential treatment for OA1. Recently, novel therapeutic high-intensive cholesterol-l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6fa1b26dee88ba580ebccdefeccc6fd
https://doi.org/10.1136/annrheumdis-2019-eular.4804

Variable cartilage degradation in mice with diet-induced metabolic dysfunction : food for thought

Autor: Hans M.G. Princen, R. Kleemann, A.E. Kozijn, Susan Kühnast, Simon C. Mastbergen, F.P.J.G. Lafeber, Harrie Weinans, Reinout Stoop, Lobke Gierman, E.J. Pieterman, R.A. van der Heijden, F. van der Ham, Anne-Marie Zuurmond, A.M. van den Hoek, Martine C. Morrison, A. Van Koppen, I. Bobeldijk, P.M. Stavro, Petra Mulder

Publikováno v: Osteoarthritis and Cartilage, 26(1), 95. W.B. Saunders Ltd
Osteoarthritis and cartilage, 26(1), 95-107. ELSEVIER SCI LTD
Osteoarthritis and Cartilage, 1, 25, 95-107

Objective: Human cohort studies have demonstrated a role for systemic metabolic dysfunction in osteoarthritis (OA) pathogenesis in obese patients. To explore the mechanisms underlying this metabolic phenotype of OA, we examined cartilage degradation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b65a74b2fe861890953043093838cf6
https://dspace.library.uu.nl/handle/1874/363420

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