Zobrazeno 1 - 10
of 22
pro vyhledávání: '"E.H. Offerman"'
Autor:
E. van de Steeg, W van Duyvenvoorde, Harm T. Jansen, Heleen M. Wortelboer, Robert Kleemann, Jeroen DeGroot, E.H. Offerman
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics, 3, 347, 635-644
Correct prediction of human pharmacokinetics (PK) and the safety and efficacy of novel compounds based on preclinical data, is essential but often fails. In the current study, we aimed to improve the predictive value of ApoE*3Leiden (E3L) trans-genic
Autor:
E.H. Offerman, Astrid Trion, Arnoud van der Laarse, Wouter Jukema, Moniek P.M. de Maat, Louis M. Havekes, Jef J. Emeis, Annemarie C.E. Maas, Hans M.G. Princen, Alexander J. Szalai
Publikováno v:
Journal of Cardiovascular Pharmacology, 47(1), 89-95. Lippincott Williams & Wilkins
We investigated the pleiotropic effects of a calcium antagonist (amlodipine) on early atherosclerosis development in the presence and absence of an HMG-CoA-reductase inhibitor (atorvastatin) in apolipoprotein E*3-Leiden/human C-reactive protein (E3L/
Autor:
M. van der Linden, M. J. Gijbels, M.P.M. de Maat, Jan H. Verheijen, Farhad Rezaee, E.H. Offerman
Publikováno v:
Thrombosis and haemostasis, 88(2), 329-334. Schattauer GmbH
SummaryAlthough many epidemiological studies have shown an association between hyperfibrinogenemia and atherosclerosis, it is not established whether elevated fibrinogen has an etiological role in the pathogenesis or is only a reflection of the ongoi
Autor:
A. van Nieuwkoop, J.W.A. van der Hoorn, A.M. van den Hoek, Annemarie C.E. Maas, E.J. Pieterman, Louis M. Havekes, Hans M.G. Princen, S. Droog, E.H. Offerman, R. M. van den Hoogen
Publikováno v:
Diabetes, Obesity and Metabolism, 16(6), 537-544
Aims: This study aimed to investigate systematically (i) the appropriate dietary conditions to induce the features of the MetS in APOE*3Leiden.humanCholesteryl Ester Transfer Protein (E3L.CETP) mice and (ii) whether the response of this model to diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61571b6ce1431b505e609eaa1ba3e095
https://hdl.handle.net/1887/103210
https://hdl.handle.net/1887/103210
Autor:
Johannes A. Romijn, V.E.H. Dahlmans, Jimmy F.P. Berbée, Patrick C.N. Rensen, Marit Westerterp, Marion J.J. Gijbels, Dianne J.M. Delsing, Miek C. Jong, E.H. Offerman, Louis M. Havekes
Publikováno v:
Journal of Lipid Research, 48(6), 1353-1361. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of Lipid Research, Vol 48, Iss 6, Pp 1353-1361 (2007)
Journal of lipid research, 48(6), 1353-1361. American Society for Biochemistry and Molecular Biology Inc.
Journal of Lipid Research, Vol 48, Iss 6, Pp 1353-1361 (2007)
Journal of lipid research, 48(6), 1353-1361. American Society for Biochemistry and Molecular Biology Inc.
Mice that overexpress human apolipoprotein C-I (apoC-I) homozygously (APOC1+/+ mice) are protected against obesity and show cutaneous abnormalities. Although these effects can result from our previous observation that apoC-I inhibits FFA generation b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::424f2a2e13258c112cf23ab3c4be72f4
https://research.rug.nl/en/publications/e7f445ce-c102-400b-8dc6-a8c65fd4f01a
https://research.rug.nl/en/publications/e7f445ce-c102-400b-8dc6-a8c65fd4f01a
Autor:
Miranda Van Eck, Louis M. Havekes, E.H. Offerman, Marit Westerterp, Patrick C.N. Rensen, Willeke de Haan, Theo J.C. Van Berkel
Publikováno v:
ATHEROSCLEROSIS, 195(1), e9-e16. ELSEVIER IRELAND LTD
Objective: Apolipoprotein CI (apoCI) is expressed in the liver and in macrophages, and has several roles in lipid metabolism. Since macrophage apoCI expression might affect macrophage lipid homeostasis and atherosclerotic lesion development locally i
Autor:
E.H. Offerman, Geesje M. Dallinga-Thie, J. Wouter Jukema, Willeke de Haan, Louis M. Havekes, Caroline C. van der Hoogt, Marit Westerterp, Patrick C.N. Rensen
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology, 26(11), 2552-2559. Lippincott Williams and Wilkins
Arteriosclerosis, thrombosis, and vascular biology, 26(11), 2552-2559. LIPPINCOTT WILLIAMS & WILKINS
Arteriosclerosis, thrombosis, and vascular biology, 26(11), 2552-2559. LIPPINCOTT WILLIAMS & WILKINS
Objective— The role of cholesteryl ester transfer protein (CETP) in the development of atherosclerosis is still undergoing debate. Therefore, we evaluated the effect of human CETP expression on atherosclerosis in APOE*3-Leiden ( E3L ) mice with a h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33457182db0ffc60aaa580c1e35f4e03
https://pure.amc.nl/en/publications/cholesteryl-ester-transfer-protein-decreases-highdensity-lipoprotein-and-severely-aggravates-atherosclerosis-in-apoe3leiden-mice(9278607c-e17f-4523-837d-9df98c44bc00).html
https://pure.amc.nl/en/publications/cholesteryl-ester-transfer-protein-decreases-highdensity-lipoprotein-and-severely-aggravates-atherosclerosis-in-apoe3leiden-mice(9278607c-e17f-4523-837d-9df98c44bc00).html
Autor:
Louis M. Havekes, Hans M.G. Princen, Joop Jukema, J.J. Emeis, Astrid Trion, M.P.M. de Maat, A. van der Laarse, Alexander J. Szalai, E.H. Offerman, M.C. Maas
Publikováno v:
Arteriosclerosis Thrombosis & Vascular Biology, 25(8), 1635-1640. Lippincott Williams & Wilkins
Arteriosclerosis, Thrombosis, and Vascular Biology, 8, 25, 1635-1640
Arteriosclerosis, Thrombosis, and Vascular Biology, 8, 25, 1635-1640
Objective - C-reactive protein (CRP) has been associated with risk of cardiovascular disease. It is not clear whether CRP is causally involved in the development of atherosclerosis. Mouse CRP is not expressed at high levels under normal conditions an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a380e414e988674b481141502f1b5283
https://pure.eur.nl/en/publications/ac2357ad-8620-4149-be88-9c2b1911a980
https://pure.eur.nl/en/publications/ac2357ad-8620-4149-be88-9c2b1911a980
Autor:
Hans M.G. Princen, E.H. Offerman, Teake Kooistra, Alexander J. Szalai, Robert Kleemann, Sjef J. Emeis, Lars Verschuren
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 25(1)
Objective - To evaluate whether low-dose atorvastatin suppresses atherosclerotic lesion progression and inflammation in apolipoprotein E*3 (apoE*3)-Leiden mice beyond its cholesterol-lowering effect. Methods and Results - ApoE*3-Leiden mice were fed
Autor:
Hans M.G. Princen, Sonia M. S. Espirito Santo, Jacques Auger, Ingrid Arnault, Wim van Duyvenvoorde, Louis M. Havekes, Bart J.M. van Vlijmen, E.H. Offerman
Publikováno v:
Atherosclerosis. 177(2)
Numerous animal studies have reported that garlic can protect against atherosclerosis. However, a comparable number of studies do not support this observation. This contradiction may result from differences in study design, use of different animal mo