Zobrazeno 1 - 10
of 31
pro vyhledávání: '"E.C.J. Coffee"'
Publikováno v:
ChemInform. 21
Starting from endo -tricyclo[5.2.1.02,6]deca-4,8-diene-3/gb-ol, which has previously been resolved, a series of transformations are described which provide access to a variety of chiral intermediates for the synthesis of carbaprostacyclin and prostag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f08613dfb4d24b358e0f696dceb8d5c
https://doi.org/10.1002/chin.199001339
https://doi.org/10.1002/chin.199001339
Autor:
T. W. Hart, H. J. Mason, C.J. Hardy, Caton Michael P L, Clive W. Bird, E.C.J. Coffee, H.I. Butler
Publikováno v:
Tetrahedron Letters. 26:4101-4104
The synthesis is described of (±)-6a-oxo-6,9-methano-15-hydroxyprosta-5,13-dienoic acids as stable analogues of prostacyclin with blood platelet aggregation inhibiting activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a263ca4dbb665d2099e7f5a8c75da9fa
https://doi.org/10.1016/s0040-4039(00)89303-x
https://doi.org/10.1016/s0040-4039(00)89303-x
Publikováno v:
Tetrahedron. 45:5655-5666
Starting from endo -tricyclo[5.2.1.02,6]deca-4,8-diene-3/gb-ol, which has previously been resolved, a series of transformations are described which provide access to a variety of chiral intermediates for the synthesis of carbaprostacyclin and prostag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a35831d96ac4a7489363465cdbc72f6d
https://doi.org/10.1016/s0040-4020(01)89508-9
https://doi.org/10.1016/s0040-4020(01)89508-9
Publikováno v:
Prostaglandins. 22:53-64
Rat uterine stimulant activity has been determined in vivo for a series of (+)-11-deoxyprostaglandins. The most active members of the series. 11-deoxy-15 methyl-PGE1, 11-deoxy-16,16-dimethyl - PGE1 and its 1-alcohol were 2-3 times more potent than PG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43499550c47451b391a5f943204dd060
https://doi.org/10.1016/0090-6980(81)90053-8
https://doi.org/10.1016/0090-6980(81)90053-8
Publikováno v:
Chemischer Informationsdienst. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::667d99474e2cbed9019b13485a547d92
https://doi.org/10.1002/chin.197421419
https://doi.org/10.1002/chin.197421419
Autor:
A.K. Banerjee, K.A.J. Stuttle, G. L. Watkins, Caton Michael P L, M.A. Heazell, E.C.J. Coffee, T.S. Burton, K. Crowshaw, B.J. Broughton, A.J. Christmas
Publikováno v:
Prostaglandins. 16(4)
The synthesis and gastrointestinal pharmacology of some 11-deoxyprostaglandin E1 analogues are described with results analysed for selectivity from side effects. 11-Deoxygenation reduced potency relative to PGE2 but, as has been reported for natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bd97e8ee3b912f2c9c6715d204b10d
https://pubmed.ncbi.nlm.nih.gov/725084
https://pubmed.ncbi.nlm.nih.gov/725084
Publikováno v:
Chemischer Informationsdienst. 6
In connection with a prostaglandin synthesis,1 we found that a cyclopentenone could be conveniently obtained by isomerisation of the corresponding 2-alkylidenecyclopentanone. We have now explored the general utility of this reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb2bc2a8c598f9569ab164d6d3187b8c
https://doi.org/10.1002/chin.197507174
https://doi.org/10.1002/chin.197507174
Publikováno v:
ChemInform. 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c070c72cd3685590bfb885b87cf00f9
https://doi.org/10.1002/chin.198808381
https://doi.org/10.1002/chin.198808381
Autor:
B.J. Broughton, M.N. Palfreyman, D.J. Hambling, Caton Michael P L, K.R.H. Wooldridge, M.T. Withnall, E.C.J. Coffee
Publikováno v:
Prostaglandins. 19(4)
Some omega-chain phenyl- and 16-phenoxy- analogues of (+/-)-11-deoxyprostaglandin F1 alpha have been synthesized and evaluated for anti-fertility activity in the hamster. 11-Deoxy-16-phenoxy-17,18,19,20-tetranor-PGF1 alpha was the most active member
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30b8f7eb920de71055a3acb22f46d999
https://pubmed.ncbi.nlm.nih.gov/7384556
https://pubmed.ncbi.nlm.nih.gov/7384556
