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The Role of Insulin-Like Growth Factor I in Age-Related Changes in Calcium Homeostasis in Men1

Autor: D. Fatayerji, R. Eastell, E.B. Mawer

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 85:4657-4662

The aim of this study was to evaluate hormonal influences on age-related changes in calcium homeostasis in men. We recruited 178 healthy men, ages 20-79 (about 30 per decade). We measured serum calcium, phosphate, urinary calcium, and creatinine clea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7df58a7534af4c8899679140954d1d4e
https://doi.org/10.1210/jcem.85.12.7031

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Constitutive synthesis of 1,25-dihydroxyvitamin D3 by a human small cell lung cancer cell line

Autor: M.E. Hayes, G.N. Smith, M. Davies, E.B. Mawer, S. E. Heys, Anne White, M F Stewart

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 79:554-560

One of 16 human small cell lung cancer cell lines examined was shown to synthesize a metabolite resembling 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. The NCI H82 line converted 25-hydroxyvitamin D3 (25OHD3) into a compound indistinguishable from 1,25-(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c46792096561713f7c5b5f2e1c97b0dd
https://doi.org/10.1210/jcem.79.2.8045976

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Metabolism of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 by blood derived macrophages from a patient with alveolar rhabdomyosarcoma during short-term culture and 1α,25-dihydroxyvitamin D3 after long-term culture

Autor: Michael Davies, D Bayley, A.J. Freemont, E.B. Mawer, J. Denton, M. Drayson, M.E. Hayes

Publikováno v: The Journal of Steroid Biochemistry and Molecular Biology. 38:301-306

We have examined the ability of blood-derived monocytes and macrophages isolated from a patient with alveolar rhabdomyosarcoma and hypercalcaemia, to form 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) or 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eb4bed93ae1fda9c30c84f7b4618309
https://doi.org/10.1016/0960-0760(91)90101-a

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Regulation of 1 alpha, 25-dihydroxyvitamin D3 synthesis in macrophages from arthritic joints by phorbol ester, dibutyryl-cAMP and calcium ionophore (A23187)

Autor: E.B. Mawer, J. Y. Yuan, M.E. Hayes, A. J. Freemont

Publikováno v: FEBS letters. 311(1)

Phorbol 12-myristate 13-acetate (100 nM), a potent protein kinase C and macrophage activator, has a biphasic affect on 25(OH)D3-1 alpha-hydroxylase activity in synovial fluid macrophages from arthritis patients. After 5 h, 1 alpha, 25(OH)D3 synthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1742276fba54fdb67ead131c53a376de
https://pubmed.ncbi.nlm.nih.gov/1327876

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The use of octadecyl-bonded microparticulate silica in the separation of free and bound fractions during saturation analysis of vitamin D metabolites

Autor: D.J.H. Trafford, E.B. Mawer, Ruth D. Coldwell, J. Nolan, Hugh L.J. Makin

Publikováno v: Journal of pharmaceutical and biomedical analysis. 10(9)

The use of octadecyl-bonded microparticulate silica to separate free and bound fractions during the saturation analysis of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D has been investigated. A slurry of octadecyl-bonded silica in an appropriate in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b4b4590cd6e532011fec570a25bc4c
https://pubmed.ncbi.nlm.nih.gov/1283701

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Synthesis of 1,25-dihydroxyvitamin D3 by spleen cells isolated from two patients with myelofibrosis and a normal subject

Autor: E.B. Mawer, D Bayley, M. Davies, M.E. Hayes, J.A.Liu Yin

Publikováno v: Journal of steroid biochemistry. 35(2)

The ability to synthesise [ 3 H]1,25(OH) 2 D 3 was studied in spleen cells incubated in short-term primary culture with [ 3 H] 25 (OH) D 3 which were isolated from two patients with idiopathic myelofibrosis and from one normal subject. Formation of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f742bd224cf9d6b7a586b8cbd8ce840
https://pubmed.ncbi.nlm.nih.gov/2308336

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