Zobrazeno 1 - 10
of 19
pro vyhledávání: '"E.B. Hookfin"'
Autor:
Timothy R. Baker, Biswanath De, Michael J. Janusz, Sandra A. Heitmeyer, Stanislaw Pikul, Neil Gregory Almstead, Michael George Natchus, Y.O. Taiwo, Vikram S. Patel, Sean X. Peng, Kimberly K. Brown, E.B. Hookfin, Lily C. Hsieh
Publikováno v:
Inflammation Research. 55:60-65
Objective and Design: Hydroxamic-and carboxylic- acid based matrix metalloproteinase inhibitors (MMPIs) were compared for their potency against various MMPs, pharmacodynamic properties and in vivo efficacy in a model of cartilage degeneration. Materi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a929852435ec2512304b9a6330b90405
https://doi.org/10.1007/s00011-005-0014-4
https://doi.org/10.1007/s00011-005-0014-4
Autor:
A R Poole, Michael J. Janusz, Y.O. Taiwo, E.B. Hookfin, Bruce Caterson, Lindsay King, Kimberly K. Brown, Christopher B. Little, Sandra A. Heitmeyer
Publikováno v:
Osteoarthritis and Cartilage. 12(9):720-728
Objective To characterize the time course of aggrecan and type II collagen degradation in the rat iodoacetate model of cartilage degeneration in relationship to the temporal sequence that has been described in human osteoarthritis (OA). Design Rats w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5449c68d531d2ad7051c3198ef0c88
Autor:
Judith A. Hoyland, Michael George Natchus, Y.O. Taiwo, Sandra A. Heitmeyer, Anthony J. Freemont, Kimberly K. Brown, Michael J. Janusz, Lily C. Hsieh, Stanislaw Pikul, J.F. Woessner, E.B. Hookfin, Biswanath De, Neil Gregory Almstead
Publikováno v:
Osteoarthritis and Cartilage. 9(8):751-760
Objective To determine the effect of matrix metalloproteinase (MMP) inhibitors in mono-iodoacetate-induced arthritis in rats. Design The ability of compounds to inhibit MMPs in vitro was assessed kinetically using a quenched fluorescent substrate. Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f622b537ec275f115385c345ba4890
Autor:
Yetunde Olabisi Taiwo, Kimberly K. Brown, Michael J. Janusz, Lily C. Hsieh, Maria Buchalova, E.B. Hookfin, Sandra A. Heitmeyer
Publikováno v:
Journal of Inflammation (London, England)
Journal of Inflammation, Vol 5, Iss 1, p 22 (2008)
Journal of Inflammation, Vol 5, Iss 1, p 22 (2008)
Background Evaluate the potential role of p38 inhibitors for the treatment of osteoarthritis using an animal model of joint degeneration (iodoacetate-induced arthritis) and a pain model (Hargraeves assay). Methods P38 kinase activity was evaluated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a561565b215e050212dcb992d87ad5
https://doi.org/10.1186/1476-9255-5-22
https://doi.org/10.1186/1476-9255-5-22
Autor:
T.E. Dufresne, E.B. Hookfin, M.J. Karb, Michael D. Cockman, C.A. Blanton, L. Dong, Kenneth R. Wehmeyer, S. Liu, Paula A. Chmielewski
Publikováno v:
Osteoarthritis and cartilage. 14(3)
Summary Objective Micro-computed tomography (microCT) imaging has the potential to allow the three-dimensional (3D) visualization of cartilage morphology. However, cartilage intensity on a microCT image is weak because cartilage does not strongly att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f376aa5cb6d0e4cb66defeeb950e493b
https://pubmed.ncbi.nlm.nih.gov/16271300
https://pubmed.ncbi.nlm.nih.gov/16271300
Autor:
Fei Gu, David M. Bornes, E.B. Hookfin, Glen E. Mieling, Matthew Pokross, Timothy R. Baker, Michael J. Strojnowski, Sandra A. Heitmeyer, Susan M. Garver, Stanislaw Pikul, David J. Foltz, Lily C. Hsieh, Vikram S. Patel, Michael George Natchus, Michael J. Janusz, Biswanath De, Sean X. Peng, Martin E. Dowty, Charles R. Dietsch, Neil Gregory Almstead, Yetunde Olabisi Taiwo, Roger G. Bookland
Publikováno v:
Journal of medicinal chemistry. 43(26)
A series of hydroxamates was prepared from an aminoproline scaffold and tested for efficacy as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for five enzymes within the MMP family, and a number of inhibitors, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0f2a0b0432bdbaffa16d228b9204e8
https://pubmed.ncbi.nlm.nih.gov/11150165
https://pubmed.ncbi.nlm.nih.gov/11150165
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 16(3)
Peptidyl fluoromethyl ketones (PFMK) are irreversible inhibitors of cathepsin B, a cysteine proteinase thought to be involved in the degradation of cartilage. It has been speculated that PFMK inhibitors may metabolize in rodents to form fluoroacetate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4934365ff1e3f81e72c48c30596b13
https://pubmed.ncbi.nlm.nih.gov/9589405
https://pubmed.ncbi.nlm.nih.gov/9589405
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