Zobrazeno 1 - 10
of 13
pro vyhledávání: '"E.Andrew Boyd"'
Autor:
Konstantinos Papadopoulos, Paul Lancett, E.Andrew Boyd, Ian Collins, Stuart Hatcher, Brian Dymock, Paul N. Mortenson, Stephanie Barker, Chandana Chowdhury, Peter Ingram, Stephen P. East, Clara Bantry White, James Workman, Christopher James Brennan, David Brown, Jim Bennett, Rowena Fletcher, Oliver Barker, Carol Smee, Emmanuelle Convers-Reignier, Mihaly Gardiner, Lloyd George Czaplewski, David J. Haydon, Helena Thomaides-Brears, Heather Tye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:894-899
The synthesis and antibacterial activities of three chemotypes of DNA supercoiling inhibitors based on imidazolo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine scaffolds that target the ATPase subunits of DNA gyrase and topoisomerase IV (GyrB/ParE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd89849d8c7c9d819089fad0a79b88d8
https://doi.org/10.1016/j.bmcl.2008.11.102
https://doi.org/10.1016/j.bmcl.2008.11.102
Publikováno v:
Tetrahedron Letters. 42:125-128
This letter describes a method for the synthesis of unsymmetrical phosphinic acids by the phosphinylation of a resin-bound aldehyde and subsequent ‘P’ alkylation. This synthetic transformation is very difficult to perform as selectively in soluti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e97031f3cea92c5a4c6e2ea89d2fe07
https://doi.org/10.1016/s0040-4039(00)01897-9
https://doi.org/10.1016/s0040-4039(00)01897-9
Autor:
E.Andrew Boyd, Anthony David Baxter, Claude Monteils, Andrew D. Proud, Vincent M. Loh, Philip B Cox
Publikováno v:
Tetrahedron Letters. 41:8177-8181
This letter describes a novel, flexible, solid phase route to pyrimidine-based heterocycles that utilises commercially available 4,6-dichloro-5-nitropyrimidine. This was exemplified by the synthesis of dihydropteridinones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ee6604c52da98732e80f34a6e5e4d6c
https://doi.org/10.1016/s0040-4039(00)01427-1
https://doi.org/10.1016/s0040-4039(00)01427-1
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2137-2140
The synthesis and preliminary pharmacological evaluation of (RS)-amino(3,5-dihydroxyphenyl)methylphosphinic acid (DHPMP) is reported. DHPMP has been identified as possessing Group I specific metabotropic agonist activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbda6e4ba431c7c6abf5c2b9a97e419f
https://doi.org/10.1016/0960-894x(96)00385-x
https://doi.org/10.1016/0960-894x(96)00385-x
Publikováno v:
Tetrahedron Letters. 37:1651-1654
Functionalised phenylphosphinic acid derivatives have been synthesised by addition of bis(trimethylsilyl)phenylphosphonite 2 to a series of electrophiles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0653d6f77c28a5adbe786c0306ae9ba5
https://doi.org/10.1016/0040-4039(96)00150-5
https://doi.org/10.1016/0040-4039(96)00150-5
Publikováno v:
Tetrahedron Letters. 37:1647-1650
Novel resin bound (RS)-1-aminophosphinic acids, prepared by the facile addition of bis(trimethylsilyl)phosphonite to 9-aryl or alkylimino-xanthen-3-yloxymethyl polystyrene, on acidolysis afforded (RS)-1-aminophosphinic acids in high yields and puriti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfdaefd1dc0b818e98c889b0609b3df2
https://doi.org/10.1016/0040-4039(96)00082-2
https://doi.org/10.1016/0040-4039(96)00082-2
Publikováno v:
Tetrahedron Letters. 33:813-816
Mono-and di-substituted phosphinic acids have been synthesised in high yield by addition of silyl phosphonites to α,β-unsaturated ketones, and conveniently purified via their adamantanammonium salts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f67d9893eea28fae568bdc01c0627245
https://doi.org/10.1016/s0040-4039(00)77722-7
https://doi.org/10.1016/s0040-4039(00)77722-7
Autor:
Ian Collins, Mark Whittaker, Caterina Noula, Mihaly Gardiner, Rebecca Ure, David Brown, E.Andrew Boyd, Lloyd George Czaplewski, Rowena Fletcher, Clare Jones, David J. Haydon, Chris Rockley, Valerie Rose, Neil R. Stokes, Stephen P. East, Helena Thomaides-Brears, Peter Ingram, Vincent Henstock, Leanne Kennison
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(2)
3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca1c1a71801ca18ebf289d52c6ffc78
https://pubmed.ncbi.nlm.nih.gov/19064318
https://pubmed.ncbi.nlm.nih.gov/19064318
Publikováno v:
Tetrahedron Letters. 31:2933-2936
Mono-substituted phosphinic acids, symmetrical and unsymmetrical disubstituted phosphinic acids have been conveniently synthesized by 1,4 addition to α,β-unsaturated esters of bis(trimethylsilyl)phosphonite generated in situ, under very mild condit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4361817f6a4921c496b5e6d0c97b207
https://doi.org/10.1016/0040-4039(90)80188-r
https://doi.org/10.1016/0040-4039(90)80188-r
Autor:
Heather Tye, Ian Collins, Konstantinos Papadopoulos, David Brown, Rowena Fletcher, Peter Ingram, Carol Smee, Stuart Hatcher, Paul N. Mortenson, Chandana Chowdhury, Lloyd George Czaplewski, James Workman, Mihaly Gardiner, Oliver Barker, Stephen P. East, Christopher James Brennan, Paul Lancett, Brian W. Dymock, Emmanuelle Convers-Reignier, Stephanie Barker, David J. Haydon, Clara Bantry White, E.Andrew Boyd, Helena Thomaides-Brears, Jim Bennett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2606
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9784f75e7d2ddb7d5b99f96922901c5
https://doi.org/10.1016/j.bmcl.2008.11.120
https://doi.org/10.1016/j.bmcl.2008.11.120