Analysis of pristanic acid β-oxidation intermediates in plasma from healthy controls and patients affected with peroxisomal disorders by stable isotope dilution gas chromatography mass spectrometry

Autor: N.M. Verhoeven, D.S.M. Schor, E.A. Struys, E.E.W. Jansen, H.J. ten Brink, R.J.A. Wanders, C. Jakobs

Publikováno v: Journal of Lipid Research, Vol 40, Iss 2, Pp 260-266 (1999)

In this paper we report the development of highly sensitive, selective, and accurate stable isotope dilution gas chromatography negative chemical ionization mass spectrometry (GC-NCI-MS) methods for quantification of peroxisomal β-oxidation intermed

Externí odkaz: https://doaj.org/article/b727506886a44338977e6d4fa94b9282

Isocaloric low protein diet in a mouse model for vanishing white matter does not impact ISR deregulation in brain, but reveals ISR deregulation in liver

Autor: Truus Em Abbink, Abdellatif Bakkali, Christopher D. Morrison, Denise Visser, Timo J. ter Braak, E.A. Struys, Marjo S van der Knaap, Lisanne E. Wisse

Publikováno v: Nutritional Neuroscience, 25(6), 1219-1230. Maney Publishing
Wisse, L E, Visser, D, ter Braak, T J, Bakkali, A, Struys, E A, Morrison, C D, van der Knaap, M S & Abbink, T E M 2022, ' Isocaloric low protein diet in a mouse model for vanishing white matter does not impact ISR deregulation in brain, but reveals ISR deregulation in liver ', Nutritional Neuroscience, vol. 25, no. 6, pp. 1219-1230 . https://doi.org/10.1080/1028415X.2020.1846356
Wisse, L E, Visser, D, ter Braak, T J, Bakkali, A, Struys, E A, Morrison, C D, van der Knaap, M S & Abbink, T E M 2020, ' Isocaloric low protein diet in a mouse model for vanishing white matter does not impact ISR deregulation in brain, but reveals ISR deregulation in liver ', Nutritional neuroscience . https://doi.org/10.1080/1028415X.2020.1846356
Nutritional neuroscience. Maney Publishing

Objective: Vanishing white matter (VWM) is a genetic brain white matter disorder caused by mutations in eIF2B. eIF2B is central in the integrated stress response (ISR), during which its activity is inhibited by various cellular stresses. VWM is a chr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69606f844515c8da945dafdc9f16b2b7
https://research.vu.nl/en/publications/4c62cd7f-455d-47fb-9f85-1730c766f395

Development and validation of a sensitive UHPLC-MS/MS-based method for the analysis of folylpolyglutamate synthetase enzymatic activity in peripheral blood mononuclear cells

Autor: E.A. Struys, Renske C. F. Hebing, Ittai B. Muller, Gerrit Jansen, Willem F. Lems, Jacqueline Cloos, Conny J. van der Laken, Robert de Jonge, Paniz Heydari, Marry Lin, Michael T. Nurmohamed

Publikováno v: Muller, I B, Lin, M, Struys, E A, Heydari, P, Hebing, R C F, Nurmohamed, M T, van der Laken, C, Lems, W F, Cloos, J, Jansen, G & de Jonge, R 2019, ' Development and validation of a sensitive UHPLC-MS/MS-based method for the analysis of folylpolyglutamate synthetase enzymatic activity in peripheral blood mononuclear cells : application in rheumatoid arthritis and leukemia patients ', Therapeutic Drug Monitoring, vol. 41, no. 5, pp. 598-606 . https://doi.org/10.1097/FTD.0000000000000638
Therapeutic Drug Monitoring, 41(5), 598-606. Lippincott Williams and Wilkins

BACKGROUND: Folylpolyglutamate synthetase (FPGS) is a crucial enzyme in both cellular folate homeostasis and the intracellular retention of folate analogue drugs such as methotrexate (MTX), which is commonly used for the treatment of (pediatric) leuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b0e8ac238f694c1b3cb95b5e0151df5
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85072746307&origin=inward

Generation, characterization, and drug sensitivities of 12 patient-derived IDH1-mutant glioma cell cultures

Autor: César Payán-Gómez, Martine L.M. Lamfers, Pier G. Mastroberardino, Ioannis Ntafoulis, Stijn L.W. Koolen, Pim J. French, Trisha V. Kers, Clemens M F Dirven, Cassandra Verheul, E.A. Struys, Youri Hoogstrate, Romain Tching Chi Yen, Sieger Leenstra, Sander Barnhoorn

Publikováno v: Neuro-Oncology Advances, 3(1):vdab103. Oxford University Press
Verheul, C, Ntafoulis, I, Kers, T V, Hoogstrate, Y, Mastroberardino, P G, Barnhoorn, S, Payán-Gómez, C, Tching Chi Yen, R, Struys, E A, Koolen, S L W, Dirven, C M F, Leenstra, S, French, P J & Lamfers, M L M 2021, ' Generation, characterization, and drug sensitivities of 12 patient-derived IDH1-mutant glioma cell cultures ', Neuro-oncology advances, vol. 3, no. 1, vdab103 . https://doi.org/10.1093/noajnl/vdab103
Neuro-oncology advances, 3(1):vdab103. Oxford University Press
Neuro-Oncology Advances
Neuro-oncology Advances

Background Mutations of the isocitrate dehydrogenase (IDH) gene occur in over 80% of low-grade gliomas and secondary glioblastomas. Despite considerable efforts, endogenous in vitro IDH-mutated glioma models remain scarce. Availability of these model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad5f6d073950160a1be8293798e386bf
https://pure.eur.nl/en/publications/45e60580-a703-4ccb-8ad9-9d6ffd013b14

No evidence for cell-to-cell transmission of the unfolded protein response in cell culture

Autor: E.A. Struys, Wiep Scheper, Ernesto Berenjeno-Correa, Petrus J Hoetjes, Anna Maria van Ziel, Kimberly Wolzak, Anna Nölle, Eelco van Anken

Publikováno v: Journal of neurochemistry, 152(2), 208-220. Wiley-Blackwell
Journal of Neurochemistry, 152(2), 208-220. Wiley-Blackwell
van Ziel, A M, Wolzak, K, Nölle, A, Hoetjes, P J, Berenjeno-Correa, E, van Anken, E, Struys, E A & Scheper, W 2020, ' No evidence for cell-to-cell transmission of the unfolded protein response in cell culture ', Journal of Neurochemistry, vol. 152, no. 2, pp. 208-220 . https://doi.org/10.1111/jnc.14856
Journal of Neurochemistry

The unfolded protein response (UPR) is one of the major cell‐autonomous proteostatic stress responses. The UPR has been implicated in the pathogenesis of neurodegenerative diseases and is therefore actively investigated as therapeutic target. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4ee83a17e19cc036ad8f294fb7c9772